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Journal of Immunotoxicology Volume 5, 2008 - Issue 2
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Research Article

Changes in Gene Expression Induced by Carbamazepine and Phenytoin: Testing the Danger Hypothesis

Wei Lu Department of Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, University of Toronto, Toronto, Ontario, Canada
,
Xujian Li Department of Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, University of Toronto, Toronto, Ontario, Canada
&
Jack P. Uetrecht Department of Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, University of Toronto, Toronto, Ontario, Canada
Pages 107-113 | Received 07 Nov 2007, Accepted 08 Jan 2008, Published online: 09 Oct 2008

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Read on this site (5)

Elif Erdem Guzel, Nalan Kaya Tektemur, Ahmet Tektemur & Ebru Etem Önalan. (2023) Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat. Drug and Chemical Toxicology 46:1, pages 136-143.
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Amy Sharma, Yoshiro Saito, Shuen-Iu Hung, Dean Naisbitt, Jack Uetrecht & Jeanine Bussiere. (2019) The skin as a metabolic and immune-competent organ: Implications for drug-induced skin rash. Journal of Immunotoxicology 16:1, pages 1-12.
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Winnie Ng, Imir G. Metushi & Jack Uetrecht. (2015) Hepatic effects of aminoglutethimide: A model aromatic amine. Journal of Immunotoxicology 12:1, pages 24-32.
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Winnie Ng & Jack Uetrecht. (2013) Changes in gene expression induced by aromatic amine drugs: Testing the danger hypothesis. Journal of Immunotoxicology 10:2, pages 178-191.
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Michael J Rieder. (2009) Immune mediation of hypersensitivity adverse drug reactions: implications for therapy. Expert Opinion on Drug Safety 8:3, pages 331-343.
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Articles from other publishers (8)

Cristobal Espinosa Ruiz, Simona Manuguerra, Eleonora Curcuraci, Andrea Santulli & Concetta M. Messina. (2020) Carbamazepine, cadmium chloride and polybrominated diphenyl ether-47, synergistically modulate the expression of antioxidants and cell cycle biomarkers, in the marine fish cell line SAF-1. Marine Environmental Research 154, pages 104844.
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Antonello Di Paolo, Elena Arrigoni, Sara Galimberti & Romano Danesi. 2017. Drug Design: Principles and Applications. Drug Design: Principles and Applications 149 168 .
S.T. Alrashood. 2016. 133 321 .
Angelique M. Leone, Erin Saleh, S. Jim Proctor, Michael F. Kelley, L. Mark Kao, Lynn Varacallo, Peter Taggart, Jean McCarthy, Monica Singer & Michael McMillian. (2014) Repression of oxidative stress/reactive metabolite regulated gene expression is associated with conversion of carbamazepine into a hepatotoxicant in LPS and DSS rat models. Advances in Bioscience and Biotechnology 05:03, pages 216-229.
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Alexander V. LyubimovJack P. Uetrecht. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 51 .
Mee Song, Youn-Jung Kim & Jae-Chun Ryu. (2011) Identification of genes induced by carbamazepine in human bronchial epithelial BEAS-2B cells. Toxicology and Environmental Health Sciences 3:2, pages 106-113.
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Céline Narjoz, Philippe Beaune & Isabelle de Waziers. (2010) Idiosyncratiques et « omiques » peuvent-ils rimer ?. médecine/sciences 26:6-7, pages 641-646.
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Amarjit S. Chaudhry, Thomas J. Urban, Jatinder K. Lamba, Angela K. Birnbaum, Rory P. Remmel, Murali Subramanian, Stephen Strom, Joyce H. You, Dalia Kasperaviciute, Claudia B. Catarino, Rodney A. Radtke, Sanjay M. Sisodiya, David B. Goldstein & Erin G. Schuetz. (2010) CYP2C9 * 1B Promoter Polymorphisms, in Linkage with CYP2C19 * 2 , Affect Phenytoin Autoinduction of Clearance and Maintenance Dose . Journal of Pharmacology and Experimental Therapeutics 332:2, pages 599-611.
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