Advanced search
Publication Cover
Autophagy Volume 12, 2016 - Issue 10
Submit an article Journal homepage
2,765
Views
51
CrossRef citations to date
0
Altmetric
Basic Research Papers

Impaired autophagy in macrophages promotes inflammatory eye disease

Andrea SantefordDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
,
Luke A. WileySteven W. Dezii Translational Vision Research Facility, Stephen A. Wynn Institute for Vision Research Department of Ophthalmology & Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
,
Sunmin ParkDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
,
Sonya BambaDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
,
Rei NakamuraDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
,
Abdelaziz GdouraDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
,
Thomas A. FergusonDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
,
P. Kumar RaoDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
,
Jun-Lin GuanDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
,
Tatsuya SaitohDepartment of Inflammation Biology, Tokushima University, Tokushima, Japan;Institute for Enzyme Research, Tokushima University, Tokushima, Japan
,
Shizuo AkiraLaboratory of Host Defense, WPI Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
,
Ramnik XavierBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA;Center for Computational and Integrative Biology and Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
,
Herbert W. VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA;Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USACorrespondence[email protected]
&
Rajendra S. ApteDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA;Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA;Neuroscience Program, Washington University School of Medicine, St. Louis, MO, USA;Department of Medicine, Washington University School of Medicine, St. Louis, MO, USACorrespondence[email protected]
 show all
Pages 1876-1885 | Received 17 Jun 2015, Accepted 24 Jun 2016, Published online: 19 Aug 2016

Citations (51)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Aarti Pant, Xiaomin Yao, Aude Lavedrine, Christophe Viret, Jacob Dockterman, Swati Chauhan, Chong-Shan Shi, Ravi Manjithaya, Ken Cadwell, Thomas A. Kufer, John H. Kehrl, Jörn Coers, L. David Sibley, Mathias Faure, Gregory A. Taylor & Santosh Chauhan. (2022) Interactions of Autophagy and the Immune System in Health and Diseases. Autophagy Reports 1:1, pages 438-515.
Read now
Anaïs Larabi, Nicolas Barnich & Hang Thi Thu Nguyen. (2020) New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy 16:1, pages 38-51.
Read now
Minghang Pei, Xinshu Liu, Chan Zhao, Fei Gao, Yong Tao & Meifen Zhang. (2019) Chemokine and Adhesion Molecule Profiles in Aqueous Humor of Clinically Quiescent Uveitic Cataracts. Current Eye Research 44:2, pages 194-199.
Read now
Yue Zhai, Peng Lin, Zhuan Feng, Huanyu Lu, Qing Han, Jun Chen, Yang Zhang, Qian He, Gang Nan, Xing Luo, Bin Wang, Fei Feng, Fenyong Liu, Zhinan Chen & Ping Zhu. (2018) TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. Autophagy 14:9, pages 1629-1643.
Read now
Vojo Deretic & Beth Levine. (2018) Autophagy balances inflammation in innate immunity. Autophagy 14:2, pages 243-251.
Read now

Articles from other publishers (46)

Xia Liu, Xiaowei Zhang, Yan Gao, Jinlong Tian & Jin Zhao. (2023) Cyanidin‐3‐galactoside from Aronia melanocarpa ameliorates PM10‐induced pulmonary inflammation by promoting PINK1/Parkin signaling pathway‐mediated alveolar macrophage mitophagy . eFood 4:6.
Crossref
Joseph B. Lin, Amy Mora, Tzu Jui Wang, Andrea Santeford, Darksha Usmani, Marianne M. Ligon, Indira U. Mysorekar & Rajendra S. Apte. (2023) Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages. mBio.
Crossref
Kazuha Mitsui, Sohei Hishiyama, Aakanksha Jain, Yumi Kotoda, Masako Abe, Takashi Matsukawa & Masakazu Kotoda. (2023) Role of macrophage autophagy in postoperative pain and inflammation in mice. Journal of Neuroinflammation 20:1.
Crossref
Yu-Qing Chen, Lian-Di Gao, Yi-Lin Liu, Ya Shen, Jia-Le Diao, Wei-Hua Yang & Rui-Li Wei. (2023) Autophagy in graves’ ophthalmopathy. Frontiers in Cell and Developmental Biology 11.
Crossref
Shangyun Lu, Jiali Xu, Yang Xu, Yang Liu, Dongxing Shi, Jia Wang & Fubin Qiu. (2023) Glycyrol attenuates colon injury via promotion of SQSTM1/p62 ubiquitination and autophagy by inhibiting the ubiquitin-specific protease USP8. Journal of Functional Foods 103, pages 105492.
Crossref
C. Mölzer, Y.-H. Liu, E. Muckersie, I. P. Klaska, R. Cornall, H. M. Wilson, L. Kuffová & J. V. Forrester. (2023) Colitis in a transgenic mouse model of autoimmune uveitis may be induced by neoantigen presentation in the bowel. Scientific Reports 13:1.
Crossref
Jing-Xing Li, Chun-Chi Chiang, San-Ni Chen, Jane-Ming Lin & Yi-Yu Tsai. (2022) The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 19:23, pages 15683.
Crossref
Luyao Tao, Kangjun Liu, Jianji Li, Yihui Zhang, Luying Cui, Junsheng Dong, Xia Meng, Guoqiang Zhu & Heng Wang. (2022) Selenomethionine alleviates NF-κB-mediated inflammation in bovine mammary epithelial cells induced by Escherichia coli by enhancing autophagy. International Immunopharmacology 110, pages 108989.
Crossref
Meng-Meng Li, Xi Wang, Xiao-Dong Chen, Hai-Long Yang, Huai-Sha Xu, Ping Zhou, Rong Gao, Ning Zhang, Jun Wang, Lei Jiang & Na Liu. (2022) Lysosomal dysfunction is associated with NLRP3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice. Behavioural Brain Research 432, pages 113987.
Crossref
Sara Monaci, Federica Coppola, Daniela Rossi, Gaia Giuntini, Irene Filippi, Giuseppe Marotta, Silvano Sozzani, Fabio Carraro & Antonella Naldini. (2022) Hypoxia Induces Autophagy in Human Dendritic Cells: Involvement of Class III PI3K/Vps34. Cells 11:10, pages 1695.
Crossref
Wen Wang, Zheng-yao Yu, Rong-hua Song, Shuang-tao He, Liang-feng Shi & Jin-an Zhang. (2022) Polymorphisms of ATG5 Gene Are Associated with Autoimmune Thyroid Diseases, Especially Thyroid Eye Disease. Journal of Immunology Research 2022, pages 1-6.
Crossref
Gavin Davis, Kin Li, Finosh G. Thankam, Daniel R. Wilson & Devendra K. Agrawal. (2022) Ocular transmissibility of COVID-19: possibilities and perspectives. Molecular and Cellular Biochemistry 477:3, pages 849-864.
Crossref
Thomas Volatier, Björn Schumacher, Claus Cursiefen & Maria Notara. (2022) UV Protection in the Cornea: Failure and Rescue. Biology 11:2, pages 278.
Crossref
Duraisamy Kempuraj & Rajiv R. Mohan. (2022) Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea. Biomedicines 10:2, pages 339.
Crossref
Tanima De, Honghong Zhang, Cristina Alarcon, Bianca Lec, Juan Avitia, Erin Smithberger, Chuyu Chen, Minnie Horvath, Sara Kwan, Mary Young, Sarbani Adhikari, John Kwon, Jennifer Pacheco, Gail Jarvik, Wei-Qi Wei, Frank Mentch, Hakon Hakonarson, Patrick Sleiman, Adam Gordon, John Harley, Jim Linneman, Scott Hebbring, Loukia Parisiadou & Minoli A. Perera. (2021) Genetic association of primary nonresponse to anti-TNFα therapy in patients with inflammatory bowel disease. Pharmacogenetics and Genomics 32:1, pages 1-9.
Crossref
Liang Liang, Qingyun Zhou & Lujia Feng. (2021) Decreased microRNA-155 in Behcet’s disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production. Arthritis Research & Therapy 23:1.
Crossref
Andrea Santeford, Aaron Y Lee, Abdoulaye Sene, Lynn M Hassman, Alexey A Sergushichev, Ekaterina Loginicheva, Maxim N Artyomov, Philip A Ruzycki & Rajendra S Apte. (2021) Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages. eLife 10.
Crossref
Caiying Zhang, Zhisheng Hu, Ruiming Hu, Shaoxing Pi, Zejing Wei, Chang Wang, Fan Yang, Chenghong Xing, Gaohui Nie & Guoliang Hu. (2021) New insights into crosstalk between pyroptosis and autophagy co-induced by molybdenum and cadmium in duck renal tubular epithelial cells. Journal of Hazardous Materials 416, pages 126138.
Crossref
Yan Liao, Jiahui Xu, Biyan Qin, Jie Shi, Caolitao Qin, Fang Xie, Shiyu Ou, Jing Tang, Weidong Wang, Fengfei Wu & Lan Bai. (2021) Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease. Free Radical Biology and Medicine 172, pages 33-47.
Crossref
Dandan Wang, Shuai Shao, Yanqiu Zhang, Daqing Zhao & Mingxing Wang. (2021) Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy. Frontiers in Immunology 12.
Crossref
Qiuyun Xu, Jie Zhang, Tingyu Qin, Jingyin Bao, Hongtao Dong, Xiaorong Zhou, Shengping Hou & Liming Mao. (2021) The role of the inflammasomes in the pathogenesis of uveitis. Experimental Eye Research 208, pages 108618.
Crossref
Mehboob Ali, Mehak Gupta, Abubakar Wani, Ankita Sharma, Mohd Abdullaha, Dilpreet Kour, Sushil Choudhary, Sandip B. Bharate, Gurdarshan Singh & Ajay Kumar. (2021) IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy. Frontiers in Pharmacology 12.
Crossref
Mimi Tang, Ting Liu, Pei Jiang & Ruili Dang. (2021) The interaction between autophagy and neuroinflammation in major depressive disorder: From pathophysiology to therapeutic implications. Pharmacological Research 168, pages 105586.
Crossref
Alicia Algaba, Iván Guerra, Elena Ricart, Eva Iglesias, Miriam Mañosa, Javier P. Gisbert, Jordi Guardiola, Miguel Mínguez, Beatriz Castro, Ruth de Francisco, Pilar Nos, Federico Bertoletti, Francisco Mesonero, Jesús Barrio, María Dolores Martín-Arranz, Xavier Calvet, Santiago García-López, Beatriz Sicilia, Gillermo Alcaín, María Esteve, Lucía Márquez, Marta Piqueras, Laura Jiménez, José L. Perez-Calle, Luis Bujanda, Mariana García-Sepulcre, Alejandra Fernández, Irene Moraleja, Rufo Humberto Lorente, Orlando García-Bosch, Ana Lambán, Isabel Blázquez, Esther Rodríguez, José M. Huguet, Alfredo J. Lucendo, Pedro Almela, David Busquets, Patricia Ramírez de la Piscina, Marcela Pérez, Eugeni Domenech & Fernando Bermejo. (2020) Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry. Digestive Diseases and Sciences 66:6, pages 2014-2023.
Crossref
Tharini Senthamizh, Kuppusamy Senthamizhselvan, Niroj Kumar Sahoo & Subashini Kaliaperumal. (2021) Panuveitis in a patient with active Crohn’s disease. BMJ Case Reports 14:2, pages e239058.
Crossref
Yunlong Fan, Jiakang Shao, Shixiong Wei, Chao Song, Yanan Li & Shengli Jiang. (2021) Self-eating and Heart: The Emerging Roles of Autophagy in Calcific Aortic Valve Disease. Aging and disease 12:5, pages 1287.
Crossref
Yidan Zhang, Yuan Zhao, Jian Zhang & Guofeng Yang. (2020) Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer’s Disease. Neurochemical Research 45:11, pages 2560-2572.
Crossref
Baptiste Pradel, Véronique Robert-Hebmann & Lucile Espert. (2020) Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses. Frontiers in Immunology 11.
Crossref
Coralie F. Daussy & Harald Wodrich. (2020) “Repair Me if You Can”: Membrane Damage, Response, and Control from the Viral Perspective. Cells 9:9, pages 2042.
Crossref
Yun-Jing Zou, Jia-Jia Xu, Xue Wang, Yao-Hong Zhu, Qiong Wu & Jiu-Feng Wang. (2020) Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells. Veterinary Sciences 7:3, pages 112.
Crossref
Jacob D. Painter, Lauriane Galle-Treger & Omid Akbari. (2020) Role of Autophagy in Lung Inflammation. Frontiers in Immunology 11.
Crossref
Ya-Ting Wang, Konstantin Zaitsev, Qun Lu, Shan Li, W. Timothy Schaiff, Ki-Wook Kim, Lindsay Droit, Craig B. Wilen, Chandni Desai, Dale R. Balce, Robert C. Orchard, Anthony Orvedahl, Sunmin Park, Darren Kreamalmeyer, Scott A. Handley, John D. Pfeifer, Megan T. Baldridge, Maxim N. Artyomov, Christina L. Stallings & Herbert W. Virgin. (2020) Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nature Microbiology 5:2, pages 272-281.
Crossref
Skirmante Rusoniene, Vaidotas Urbonas & Tadej Avcin. 2020. Periodic and Non-Periodic Fevers. Periodic and Non-Periodic Fevers 177 213 .
Reham M Alsaadi, Truc T Losier, Wensheng Tian, Anne Jackson, Zhihao Guo, David C Rubinsztein & Ryan C Russell. (2019) ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant. EMBO reports 20:7.
Crossref
Nina Germic, Ziva Frangez, Shida Yousefi & Hans-Uwe Simon. (2019) Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation. Cell Death & Differentiation 26:4, pages 715-727.
Crossref
Judith Houtman, Kiara Freitag, Niclas Gimber, Jan Schmoranzer, Frank L Heppner & Marina Jendrach. (2019) Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP 3 . The EMBO Journal 38:4.
Crossref
Wenzhuo He, Wenjing Xiong & Xiaojun Xia. 2019. Autophagy Regulation of Innate Immunity. Autophagy Regulation of Innate Immunity 7 22 .
Norimitsu Ban, Tae Jun Lee, Abdoulaye Sene, Mayur Choudhary, Michael Lekwuwa, Zhenyu Dong, Andrea Santeford, Jonathan B. Lin, Goldis Malek, Daniel S. Ory & Rajendra S. Apte. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:17.
Crossref
Norimitsu Ban, Tae Jun Lee, Abdoulaye Sene, Zhenyu Dong, Andrea Santeford, Jonathan B. Lin, Daniel S. Ory & Rajendra S. Apte. (2018) Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. Journal of Lipid Research 59:8, pages 1414-1423.
Crossref
Yike Huang, Junchi He, Huaping Liang, Ke Hu, Shaoqiu Jiang, Lu Yang, Suyin Mei, Xiao Zhu, Jing Yu, Aize Kijlstra, Peizeng Yang & Shengping Hou. (2018) Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis. Frontiers in Immunology 9.
Crossref
Cynthia Louis, Chris Burns & Ian Wicks. (2018) TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity. Frontiers in Immunology 9.
Crossref
Michihiro Takahama, Shizuo Akira & Tatsuya Saitoh. (2018) Autophagy limits activation of the inflammasomes. Immunological Reviews 281:1, pages 62-73.
Crossref
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R. Green & Guido Kroemer. (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nature Reviews Drug Discovery 16:7, pages 487-511.
Crossref
Jung Hwa Ko, Sun-Ok Yoon, Hyun Ju Lee & Joo Youn Oh. (2017) Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners. Oncotarget 8:25, pages 40817-40831.
Crossref
Kai Kaarniranta, Goran Petrovski & Anu Kauppinen. (2017) The Nobel Prized cellular target autophagy in eye diseases. Acta Ophthalmologica 95:4, pages 335-336.
Crossref
Leandro Lopes Troncoso, Ana Luiza Biancardi, Haroldo Vieira de Moraes Jr & Cyrla Zaltman. (2017) Ophthalmic manifestations in patients with inflammatory bowel disease: A review. World Journal of Gastroenterology 23:32, pages 5836.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.