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Autophagy Volume 15, 2019 - Issue 2
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Research Paper - Basic Science

Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy

So Woon KimDepartment of Physiology, Sungkyunkwan University School of Medicine, Suwon, KoreaORCID Iconhttp://orcid.org/0000-0002-8875-539XView further author information
ORCID Icon,
Dong Hyun KimDepartment of Physiology, Sungkyunkwan University School of Medicine, Suwon, KoreaView further author information
,
Kyoung Sun ParkWide River Institute of Immunology, Seoul National University College of Medicine, Gangwon-do, KoreaORCID Iconhttp://orcid.org/0000-0002-0421-0510View further author information
ORCID Icon,
Mi Kyung KimDepartment of Physiology, Sungkyunkwan University School of Medicine, Suwon, KoreaView further author information
,
Yun Min ParkDepartment of Physiology, Sungkyunkwan University School of Medicine, Suwon, KoreaORCID Iconhttp://orcid.org/0000-0002-3532-5222View further author information
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Shmuel MuallemEpithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0002-6189-4947View further author information
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Insuk SoDepartment of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, KoreaORCID Iconhttp://orcid.org/0000-0003-2294-2050View further author information
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Hyun Jin KimDepartment of Physiology, Sungkyunkwan University School of Medicine, Suwon, Korea;Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, KoreaCorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-5806-4416View further author information
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Pages 327-340 | Received 29 Sep 2017, Accepted 28 Aug 2018, Published online: 14 Sep 2018

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Yuchen Lei & Daniel J. Klionsky. (2023) MCOLN3/TRPML3 bridges the regulation of autophagosome biogenesis by PtdIns3P and the calcium channel. Autophagy 19:2, pages 377-378.
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Jee-Eun Lee, Nari Kim, Minkyo Jung, Ji-Young Mun & Joo-Yeon Yoo. (2022) SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores. Autophagy 18:7, pages 1613-1628.
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Ruoxi Zhang, Rui Kang, Daniel J. Klionsky & Daolin Tang. (2022) Ion Channels and Transporters in Autophagy. Autophagy 18:1, pages 4-23.
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Articles from other publishers (28)

Yoona Jung, Wonjoon Kim, Na Kyoung Shin, Young Min Bae & Jinhong Wie. (2023) Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis. The Korean Journal of Physiology & Pharmacology 27:4, pages 311-323.
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Xi Tan, Chenhui Wang, Hong Zhou, Shuting Zhang, Xuhan Liu, Xiangliang Yang & Wei Liu. (2023) Bioactive fatty acid analog-derived hybrid nanoparticles confer antibody-independent chemo-immunotherapy against carcinoma. Journal of Nanobiotechnology 21:1.
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Mashoque Ahmad Rather, Andleeb Khan, Lianchun Wang, Sadaf Jahan, Muneeb U. Rehman, Hafiz A. Makeen & Syam Mohan. (2023) TRP channels: Role in neurodegenerative diseases and therapeutic targets. Heliyon 9:6, pages e16910.
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Zhiqiang Xia, Lixia Xie, Dongyuan Li, Xinyi Hong & Chenhu Qin. (2023) Gene expression of TRPMLs and its regulation by pathogen stimulation. Gene 864, pages 147291.
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So Woon Kim, Mi Kyung Kim, Seokwoo Hong, Areum Choi, Jee Hye Choi, Shmuel Muallem, Insuk So, Dongki Yang & Hyun Jin Kim. (2022) The intracellular Ca 2+ channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis . Proceedings of the National Academy of Sciences 119:43.
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Mi Seong Kim, Sei Hoon Yang & Min Seuk Kim. (2022) TRPML3 enhances drug resistance in non-small cell lung cancer cells by promoting Ca2+-mediated lysosomal trafficking. Biochemical and Biophysical Research Communications 627, pages 152-159.
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Hongbo Li, Yanglan Liao, Xuanang Zheng, Xiaohong Zhuang, Caiji Gao & Jun Zhou. (2022) Shedding Light on the Role of Phosphorylation in Plant Autophagy. FEBS Letters 596:17, pages 2172-2185.
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Bo Xie & Xiuzu Song. (2021) The impaired unfolded protein‐premelanosome protein and transient receptor potential channels‐autophagy axes in apoptotic melanocytes in vitiligo. Pigment Cell & Melanoma Research 35:1, pages 6-17.
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Xitang Li, Qiang Gao, Wenhui Wu, Suping Hai, Junjian Hu, Jie You, Da Huang, Hongwu Wang, Di Wu, Meifang Han, Dong Xi, Weiming Yan, Tao Chen, Xiaoping Luo, Qin Ning & Xiaojing Wang. (2022) FGL2–MCOLN3-Autophagy Axis–Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis. Cellular and Molecular Gastroenterology and Hepatology 14:5, pages 1077-1101.
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Lu Hu, Zhipeng Tao & Xu Wu. (2021) Insights into auto- S -fatty acylation: targets, druggability, and inhibitors . RSC Chemical Biology 2:6, pages 1567-1579.
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Benedikt Goretzki, Charlotte Guhl, Frederike Tebbe, Jean-Martin Harder & Ute A. Hellmich. (2021) Unstructural Biology of TRP Ion Channels: The Role of Intrinsically Disordered Regions in Channel Function and Regulation. Journal of Molecular Biology 433:17, pages 166931.
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Tamal Sadhukhan, Maria B. Bagh, Abhilash P. Appu, Avisek Mondal, Wei Zhang, Aiyi Liu & Anil B. Mukherjee. (2021) In a mouse model of INCL reduced S‐palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation . Journal of Inherited Metabolic Disease 44:4, pages 1051-1069.
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Kiall F. Suazo, Keun-Young Park & Mark D. Distefano. (2021) A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications. Chemical Reviews 121:12, pages 7178-7248.
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Gonçalo Mesquita, Natalia Prevarskaya, Albrecht Schwab & V’yacheslav Lehen’kyi. (2021) Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression. Cells 10:5, pages 1021.
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A. Scotto Rosato, R. Tang & C. Grimm. (2021) Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis. Pharmacology & Therapeutics 220, pages 107713.
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Wanshan Ning, Peiran Jiang, Yaping Guo, Chenwei Wang, Xiaodan Tan, Weizhi Zhang, Di Peng & Yu Xue. (2021) GPS-Palm: a deep learning-based graphic presentation system for the prediction of S -palmitoylation sites in proteins . Briefings in Bioinformatics 22:2, pages 1836-1847.
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Yi Wu, Peng Huang & Xian-Ping Dong. (2021) Lysosomal Calcium Channels in Autophagy and Cancer. Cancers 13:6, pages 1299.
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Shihua Li, Kai Yu, Guandi Wu, Qingfeng Zhang, Panqin Wang, Jian Zheng, Ze-Xian Liu, Jichao Wang, Xinjiao Gao & Han Cheng. (2021) pCysMod: Prediction of Multiple Cysteine Modifications Based on Deep Learning Framework. Frontiers in Cell and Developmental Biology 9.
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Mengnan Xu & Xian-Ping Dong. (2021) Endolysosomal TRPMLs in Cancer. Biomolecules 11:1, pages 65.
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Diego L. Medina. 2021. Inter-Organellar Ca2+ Signaling in Health and Disease - Part A. Inter-Organellar Ca2+ Signaling in Health and Disease - Part A 141 170 .
Zeang Wu, Rubin Tan, Liping Zhu, Ping Yao & Qinghua Hu. 2021. Lung Inflammation in Health and Disease, Volume II. Lung Inflammation in Health and Disease, Volume II 165 186 .
Zhiqiang Xia, Luyao Wang, Songryong Li, Wei Tang, Fang Sun, Yingliang Wu, Lixia Miao & Zhijian Cao. (2020) ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Research 182, pages 104922.
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Dawid Jaślan, Julia Böck, Einar Krogsaeter & Christian Grimm. (2020) Evolutionary Aspects of TRPMLs and TPCs. International Journal of Molecular Sciences 21:11, pages 4181.
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Giorgio Santoni, Matteo Santoni, Federica Maggi, Oliviero Marinelli & Maria Beatrice Morelli. (2020) Emerging Role of Mucolipins TRPML Channels in Cancer. Frontiers in Oncology 10.
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Barbara Spix, Yu-Kai Chao, Carla Abrahamian, Cheng-Chang Chen & Christian Grimm. (2020) TRPML Cation Channels in Inflammation and Immunity. Frontiers in Immunology 11.
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Chansik Hong, Seo Hwa Choi, Misun Kwak, Byeongseok Jeong, Juyeon Ko, Hyung Joon Park, Seok Choi, Jae Yeoul Jun & Insuk So. (2020) TRPC5 channel instability induced by depalmitoylation protects striatal neurons against oxidative stress in Huntington's disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867:2, pages 118620.
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Mengwei Wu, Xiaobin Li, Taiping Zhang, Ziwen Liu & Yupei Zhao. (2019) Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer. Frontiers in Oncology 9.
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