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Autophagy Volume 15, 2019 - Issue 11
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Research Paper

Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy

Yong-Guo ZhangDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USAORCID Iconhttps://orcid.org/0000-0002-8299-0233View further author information
ORCID Icon,
Xiaorong ZhuDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USAView further author information
,
Rong LuDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USAORCID Iconhttps://orcid.org/0000-0003-4564-8890View further author information
ORCID Icon,
Jeannette S. MesserDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USAORCID Iconhttps://orcid.org/0000-0002-5072-3835View further author information
ORCID Icon,
Yinglin XiaDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USAView further author information
,
Eugene B. ChangDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USACorrespondence[email protected]
View further author information
&
Jun SunDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7465-3133View further author information
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Pages 1935-1953 | Received 22 Apr 2018, Accepted 01 Mar 2019, Published online: 09 Apr 2019

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Bo Chen, Yingjun Yang, Jinbo Wu, Jianjiang Song & Jia Lu. (2022) microRNA-17-5p downregulation inhibits autophagy and myocardial remodelling after myocardial infarction by targeting STAT3. Autoimmunity 55:1, pages 43-51.
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Daolin Tang, Rui Kang, Herbert J. Zeh & Michael T. Lotze. (2023) The multifunctional protein HMGB1: 50 years of discovery. Nature Reviews Immunology 23:12, pages 824-841.
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Jun Sun & Yinglin Xia. 2011. Comprehensive Physiology. Comprehensive Physiology 4685 4708 .
Shuang-Lan Chen, Chun-Meng Li, Wei Li, Qing-Song Liu, Shuang-Yuan Hu, Mao-Yuan Zhao, Dong-Sen Hu, Yan-Wei Hao, Jin-Hao Zeng & Yi Zhang. (2023) How autophagy, a potential therapeutic target, regulates intestinal inflammation. Frontiers in Immunology 14.
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Zhi Zhao, Zhizhi Hu, Rui Zeng & Ying Yao. (2020) HMGB1 in kidney diseases. Life Sciences 259, pages 118203.
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Anirban Mukherjee & Karen M. Vasquez. (2020) Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy. Cancer Research 80:11, pages 2075-2082.
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Ying Yu, Wenxian Ou-Yang, Hui Zhang, Tao Jiang, William C Cho, Huang Zhu, Zhenghui Xiao & Shuangjie Li. (2020) High-mobility Group Box 1 Facilitates CD4 T Cell Self-aggregation Via Integrin and STAT3 Activation Before Homing. Inflammatory Bowel Diseases.
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Yang Jiao & Jun Sun. (2019) Bacterial Manipulation of Autophagic Responses in Infection and Inflammation. Frontiers in Immunology 10.
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