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Autophagy Volume 15, 2019 - Issue 8
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Autophagic Punctum

DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy

Anne Vehlowa OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany;b National Center for Tumor Diseases (NCT), Partner Site Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany;c German Cancer Consortium (DKTK), Partner Site Dresden, and DKFZ, Heidelberg, GermanyORCID Iconhttps://orcid.org/0000-0002-5381-0547View further author information
ORCID Icon &
Nils Cordesa OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany;d Helmholtz-Zentrum Dresden, Rossendorf, Institute of Radiooncology, OncoRay, Dresden, Germany;e University Hospital Carl Gustav Carus, Faculty of Medicine, Department of Radiation Oncology, Technische Universität Dresden, Dresden, Germany;c German Cancer Consortium (DKTK), Partner Site Dresden, and DKFZ, Heidelberg, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5684-629XView further author information
ORCID Icon
Pages 1487-1488 | Received 10 Apr 2019, Accepted 07 May 2019, Published online: 23 May 2019

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Jing Guo, Zhen Zhang & Ke Ding. (2020) A patent review of discoidin domain receptor 1 (DDR1) modulators (2014-present). Expert Opinion on Therapeutic Patents 30:5, pages 341-350.
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Articles from other publishers (21)

Hui Xu, Ming Tan, Guo-Qing Hou, Ya-Zhou Sang, Li Lin, Xiao-Cai Gan, Xuan Cao & An-Dong Liu. (2023) Blockade of DDR1/PYK2/ERK signaling suggesting SH2 superbinder as a novel autophagy inhibitor for pancreatic cancer. Cell Death & Disease 14:12.
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Xiaowei Liu, Hu Li, Tingrui Wang, Ting Yang, Xia Yang, Kaixuan Guo, Lina Hu & Jia Ming. (2023) Recombinant humanized collagen type III with high antitumor activity inhibits breast cancer cells autophagy, proliferation, and migration through DDR1. International Journal of Biological Macromolecules 243, pages 125130.
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Shilah A. Bonnett, Alyssa B. Rosenbloom, Giang T. Ong, Mark Conner, Aric B.E. Rininger, Daniel Newhouse, Felicia New, Chi Q. Phan, Saskia Ilcisin, Hiromi Sato, John S. Lyssand, Gary Geiss & Joseph M. Beechem. (2023) Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles. Cancer Research Communications 3:5, pages 763-779.
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Francesco Paolo Cammarata, Filippo Torrisi, Nunzio Vicario, Valentina Bravatà, Alessandro Stefano, Lucia Salvatorelli, Simona D’Aprile, Pierangela Giustetto, Giusi Irma Forte, Luigi Minafra, Marco Calvaruso, Selene Richiusa, Giuseppe Antonio Pablo Cirrone, Giada Petringa, Giuseppe Broggi, Sebastiano Cosentino, Fabrizio Scopelliti, Gaetano Magro, Danilo Porro, Massimo Libra, Massimo Ippolito, Giorgio Russo, Rosalba Parenti & Giacomo Cuttone. (2023) Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model. Communications Biology 6:1.
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Daniel Rivera, Alexander J. Schupper, Alexandros Bouras, Maria Anastasiadou, Lawrence Kleinberg, Dara L. Kraitchman, Anilchandra Attaluri, Robert Ivkov & Constantinos G. Hadjipanayis. (2023) Neurosurgical Applications of Magnetic Hyperthermia Therapy. Neurosurgery Clinics of North America 34:2, pages 269-283.
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Dongjiao Wang, Yuxue Jiang, Tie Wang, Zhe Wang & Fei Zou. (2022) Identification of a novel autophagy-related prognostic signature and small molecule drugs for glioblastoma by bioinformatics. BMC Medical Genomics 15:1.
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Syed M. Faisal, Andrea Comba, Maria L. Varela, Anna E. Argento, Emily Brumley, Clifford AbelIIII, Maria G. Castro & Pedro R. Lowenstein. (2022) The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications. Frontiers in Oncology 12.
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Jingjing Zhu, Huang Cheng, Lan Wang, Weide Xu, Junqing Wang, Qing Han, Jong-ho Lee, Linyong Du & Jianxin Lyu. (2022) Discoidin domain receptor 1 promotes lung adenocarcinoma migration via the AKT/snail signaling axis. Molecular Biology Reports 49:8, pages 7275-7286.
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Reui‐Liang Yan & Ruey‐Hwa Chen. (2021) Autophagy and cancer metabolism—The two‐way interplay. IUBMB Life 74:4, pages 281-295.
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Rui Ma, Xudong Xie, Lei Zhao, Yafei Wu & Jun Wang. (2021) Discoidin domain receptors (DDRs): Potential implications in periodontitis. Journal of Cellular Physiology 237:1, pages 189-198.
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Wenjia Ma, Yu Zhou, Min Liu, Qilin Qin & Yan Cui. (2021) Long non-coding RNA LINC00470 in serum derived exosome: a critical regulator for proliferation and autophagy in glioma cells. Cancer Cell International 21:1.
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William A. Denny & Jack U. Flanagan. (2021) Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation. Biomolecules 11:11, pages 1671.
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Laura Poillet-Perez, Jean-Emmanuel Sarry & Carine Joffre. (2021) Autophagy is a major metabolic regulator involved in cancer therapy resistance. Cell Reports 36:7, pages 109528.
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Yanling Lin, Xiaohan Zhou, Kaifan Yang, Yuting Chen, Lingzhi Wang, Wenxiao Luo, Yujiang Li, Jinrong Liao, Yingtong Zhou, Yiming Lei, Yanting Zhang, Dehua Wu & Longmei Cai. (2021) Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma. Oncogene 40:17, pages 3101-3117.
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Sandra Majo & Patrick Auguste. (2021) The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development. Cancers 13:7, pages 1725.
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Imran Khan, Mohammad Hassan Baig, Sadaf Mahfooz, Moniba Rahim, Busra Karacam, Elif Burce Elbasan, Ilya Ulasov, Jae-June Dong & Mustafa Aziz Hatiboglu. (2021) Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma. International Journal of Molecular Sciences 22:3, pages 1318.
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Ru Dong, Xin Zhou, Min Wang, Wen Li, Jin-Yang Zhang, Xin Zheng, Kai-Xiang Tang & Li-Ping Sun. (2021) Discovery of 4-amino-1H-pyrazolo[3,4-d]pyrimidin derivatives as novel discoidin domain receptor 1 (DDR1) inhibitors. Bioorganic & Medicinal Chemistry 29, pages 115876.
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Girieca Lorusso, Curzio Rüegg & François Kuonen. (2020) Targeting the Extra-Cellular Matrix—Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors. Frontiers in Oncology 10.
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Patrick Auguste, Birgit Leitinger, Christelle Liard, Virginie Rocher, Laurent Azema, Frederic Saltel & David Santamaria. (2020) Meeting report – first discoidin domain receptors meeting. Journal of Cell Science 133:4.
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Benjamin Wasinski, Anjum Sohail, R. Daniel Bonfil, Seongho Kim, Allen Saliganan, Lisa Polin, Mohamad Bouhamdan, Hyeong-Reh C. Kim, Marco Prunotto & Rafael Fridman. (2020) Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts. Scientific Reports 10:1.
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Ping Mao, Gang Bao, Yi-Chang Wang, Chang-Wang Du, Xiao Yu, Xiao-Ye Guo, Rui-Chun Li & Mao-De Wang. (2020) PDZ-Binding Kinase-Dependent Transcriptional Regulation of CCNB2 Promotes Tumorigenesis and Radio-Resistance in Glioblastoma. Translational Oncology 13:2, pages 287-294.
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