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Autophagy Volume 17, 2021 - Issue 7
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Research Paper

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

Zu-Guo Zhenga State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Si-Tong Zhua State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China;b Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Hui-Min Chenga State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Xin Zhanga State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Gang Chengc Beijing Kanglisheng Pharmaceutical Technology Development Co., Ltd, Beijing, ChinaView further author information
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Pyone Myat Thua State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Supeng Perry Wangd Appleby College, Oakville, Ontario, CanadaView further author information
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Hui-Jun Lia State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Ming Dinga State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Lei Qianga State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Xiao-Wei Chene State Key Laboratory of Membrane Biology, Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, ChinaView further author information
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Qing Zhongf School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaView further author information
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Ping Lia State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaCorrespondence[email protected]
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&
Xiaojun Xua State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China;b Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, Jiangsu, ChinaCorrespondence[email protected]
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Pages 1592-1613 | Received 17 Oct 2019, Accepted 12 Apr 2020, Published online: 20 May 2020

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