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Autophagy Volume 17, 2021 - Issue 7
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Research Paper

HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons

Maryline Santerrea Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USACorrespondence[email protected]
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,
Sterling P Arjonaa Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USAView further author information
,
Charles Ns Allena Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USAView further author information
,
Shannon Callenb Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USAORCID Iconhttps://orcid.org/0000-0001-6241-3335View further author information
ORCID Icon,
Shilpa Buchb Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USAORCID Iconhttps://orcid.org/0000-0002-3103-6685View further author information
ORCID Icon &
Bassel E Sawayaa Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA;c Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USACorrespondence[email protected]
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Pages 1768-1782 | Received 26 Jun 2020, Accepted 07 Apr 2021, Published online: 23 Apr 2021

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Phelippe Carmo-Gonçalves, Eduardo Coelho-Cerqueira, Vanderlei de Araujo Lima & Cristian Follmer. (2023) Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection. Expert Review of Neurotherapeutics 23:4, pages 321-330.
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Articles from other publishers (8)

Gaurav Datta, Nicole M. Miller & Xuesong Chen. (2023) 17⍺-Estradiol Protects against HIV-1 Tat-Induced Endolysosome Dysfunction and Dendritic Impairments in Neurons. Cells 12:5, pages 813.
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Valentina Leta, Daniele Urso, Lucia Batzu, Yue Hui Lau, Donna Mathew, Iro Boura, Vanessa Raeder, Cristian Falup-Pecurariu, Daniel van Wamelen & K. Ray Chaudhuri. (2022) Viruses, parkinsonism and Parkinson’s disease: the past, present and future. Journal of Neural Transmission 129:9, pages 1119-1132.
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Pascal Leblanc & Ina Maja Vorberg. (2022) Viruses in neurodegenerative diseases: More than just suspects in crimes. PLOS Pathogens 18:8, pages e1010670.
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Charles N. S. Allen, Sterling P. Arjona, Maryline Santerre, Claudio De Lucia, Walter J. Koch & Bassel E. Sawaya. (2022) Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders. Frontiers in Cellular Neuroscience 16.
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Charles N. S. Allen, Sterling P. Arjona, Maryline Santerre & Bassel E. Sawaya. (2022) Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis. Viruses 14:3, pages 602.
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Gaurav Datta, Nicole M. Miller, Wenjuan Du, Jonathan D. Geiger, Sulie Chang & Xuesong Chen. (2021) Endolysosome Localization of ERα Is Involved in the Protective Effect of 17α-Estradiol against HIV-1 gp120-Induced Neuronal Injury. The Journal of Neuroscience 41:50, pages 10365-10381.
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Amit Jaisi, Prema, Siribhorn Madla, Yuan‐E Lee, Abdi Septama & Hiroyuki Morita. (2021) Investigation of HIV‐1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents. Chemistry & Biodiversity 18:12.
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Xiangxu Jia, Qiujia Shao, Ahsen R. Chaudhry, Ballington L. Kinlock, Michael G. Izban, Hong-Ying Zhang, Fernando Villalta, James E. K. Hildreth & Bindong Liu. (2021) Medroxyprogesterone Acetate (MPA) Enhances HIV-1 Accumulation and Release in Primary Cervical Epithelial Cells by Inhibiting Lysosomal Activity. Pathogens 10:9, pages 1192.
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