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Autophagy Volume 19, 2023 - Issue 1
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Research Paper

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD

Urvi Guptaa Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Sayan Ghosha Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
,
Callen T. Wallaceb Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAORCID Iconhttps://orcid.org/0000-0001-6852-4976View further author information
ORCID Icon,
Peng Shanga Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
,
Ying Xinc Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USAORCID Iconhttps://orcid.org/0000-0002-1856-0482View further author information
ORCID Icon,
Archana Padmanabhan Naird GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, IndiaView further author information
,
Meysam Yazdankhaha Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Anastasia Strizhakovaa Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
,
Mark A. Rossb Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Haitao Liua Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAORCID Iconhttps://orcid.org/0000-0002-3757-779XView further author information
ORCID Icon,
Stacey Hosea Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
,
Nadezda A. Stepichevaa Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Olivia Chowdhurya Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Mihir Nemania Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Vishnu Maddipatlaa Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
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Rhonda Grebec Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USAORCID Iconhttps://orcid.org/0000-0003-1841-9777View further author information
ORCID Icon,
Manjula Dase Molecular Immunology, Mazumdar Shaw Medical Foundation, Bengaluru, IndiaView further author information
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Kira L. Lathropa Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;f Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USAView further author information
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José-Alain Sahela Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;g Institut De La Vision, INSERM, CNRS, Sorbonne Université, Paris, FranceORCID Iconhttps://orcid.org/0000-0002-4831-1153View further author information
ORCID Icon,
J. Samuel Zigler Jrc Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
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Jiang Qianc Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
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Arkasubhra Ghoshd GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, IndiaView further author information
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Yuri Sergeevh National Eye Institute, National Institutes of Health, Bethesda, MD, USAView further author information
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James T. Handac Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
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Claudette M. St. Croixb Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAView further author information
&
Debasish Sinhaa Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;b Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;c Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence[email protected]
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Pages 92-111 | Received 03 Nov 2021, Accepted 01 Apr 2022, Published online: 26 Apr 2022

Citations (8)

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Byung-Kwon Jung, Yujin Park, Boran Yoon, Jin-Sil Bae, Seung-Woo Han, Ji-Eun Heo, Dong-Eun Kim & Kwon-Yul Ryu. (2023) Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage. Autophagy 19:8, pages 2296-2317.
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Articles from other publishers (7)

Xia Liu, Yunjie Li, Shiling Chen, Jingfei Yang, Jie Jing, Jiarui Li, Xuan Wu, Jiahui Wang, Jingyi Wang, Ge Zhang, Zhouping Tang & Hao Nie. (2023) Dihydromyricetin attenuates intracerebral hemorrhage by reversing the effect of LCN2 via the system Xc- pathway. Phytomedicine 115, pages 154756.
Crossref
Xiaodi Lv, Weifeng Tang, Jingjing Qin, Wenqian Wang, Jingcheng Dong & Ying Wei. (2023) The crosslinks between ferroptosis and autophagy in asthma. Frontiers in Immunology 14.
Crossref
Yue Chen, Ze-Min Fang, Xin Yi, Xiang Wei & Ding-Sheng Jiang. (2023) The interaction between ferroptosis and inflammatory signaling pathways. Cell Death & Disease 14:3.
Crossref
Shuaishuai Zhang, Yingzhe Qiu, Yuan Feng, Yi Zhang, Yanan Li, Boxin Wang, Heliang Wei, Xilong Chen, Lixia Shen, Wei Li, Liqing Zheng & Yuanyuan Zhang. (2023) Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO3 Stimulation. Oxidative Medicine and Cellular Longevity 2023, pages 1-18.
Crossref
Kexin Liu, Huazhang Li, Feng Wang & Ying Su. (2023) Ferroptosis: mechanisms and advances in ocular diseases. Molecular and Cellular Biochemistry.
Crossref
Zheng Xie, Xuan Wang, Xiaoxiao Luo, Jing Yan, Jie Zhang, Rao Sun, Ailin Luo & Shiyong Li. (2023) Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. Biochemical Pharmacology 207, pages 115374.
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Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J. Samuel ZiglerJr.Jr., Matthew Campbell, Debasish Sinha, James T. Handa, Kai Kaarniranta, Jiang Qian & Sayan Ghosh. (2022) Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model. Cells 11:22, pages 3535.
Crossref

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