Autophagy, Volume 19, Issue 1 (2023)

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Autophagy, Volume 19, Issue 1 (2023)

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Editor’s Corner

Editorial
The autophagy pathway beyond model organisms: an evolutionary perspective
Sidi Zhang & Noboru Mizushima
Pages: 1-2
Published online: 06 Dec 2022
AbstractforThe autophagy pathway beyond model organisms: an evolutionary perspective | Full Text | References | PDF (223.1 KB) | EPUB
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Review

Review
The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection
Mohd Shariq, Neha Quadir, Anwar Alam, Sheeba Zarin, Javaid A. Sheikh, Neha Sharma, Jasmine Samal, Uzair Ahmad, Indu Kumari, Seyed E. Hasnain & Nasreen Z. Ehtesham
Pages: 3-23
Published online: 09 Jan 2022
AbstractforThe exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Review
Crosstalk between cilia and autophagy: implication for human diseases
Manuela Morleo, Helena L.A. Vieira, Petra Pennekamp, Alessandro Palma, Liliana Bento-Lopes, Heymut Omran, Susana S. Lopes, Duarte C. Barral & Brunella Franco
Pages: 24-43
Published online: 25 May 2022
AbstractforCrosstalk between cilia and autophagy: implication for human diseases | Full Text | References | PDF (2.6 MB) | EPUB
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Review Article
Multifaceted roles of TAX1BP1 in autophagy
Jesse White, Sujit Suklabaidya, Mai Tram Vo, Young Bong Choi & Edward W. Harhaj
Pages: 44-53
Published online: 09 May 2022
AbstractforMultifaceted roles of TAX1BP1 in autophagy | Full Text | References | PDF (1.3 MB) | EPUB
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Research Paper

Article
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis
Xin Chen, Xinxin Song, Jingbo Li, Ruoxi Zhang, Chunhua Yu, Zhuan Zhou, Jiao Liu, Siyan Liao, Daniel J. Klionsky, Guido Kroemer, Jinbao Liu, Daolin Tang & Rui Kang
Pages: 54-74
Published online: 10 Apr 2022
AbstractforIdentification of HPCAL1 as a specific autophagy receptor involved in ferroptosis | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
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Article
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage
Yuhua Zhang, Qiaojun Fang, Hongfeng Wang, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng, Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang, Xia Gao, Zheng Ying & Renjie Chai
Pages: 75-91
Published online: 26 Apr 2022
AbstractforIncreased mitophagy protects cochlear hair cells from aminoglycoside-induced damage | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 4363 Views
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Article
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
Urvi Gupta, Sayan Ghosh, Callen T. Wallace, Peng Shang, Ying Xin, Archana Padmanabhan Nair, Meysam Yazdankhah, Anastasia Strizhakova, Mark A. Ross, Haitao Liu, Stacey Hose, Nadezda A. Stepicheva, Olivia Chowdhury, Mihir Nemani, Vishnu Maddipatla, Rhonda Grebe, Manjula Das, Kira L. Lathrop, José-Alain Sahel, J. Samuel Zigler Jr, Jiang Qian, Arkasubhra Ghosh, Yuri Sergeev, James T. Handa, Claudette M. St. Croix & Debasish Sinha
Pages: 92-111
Published online: 26 Apr 2022
AbstractforIncreased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Article
Starvation after infection restricts enterovirus D68 replication
Alagie Jassey, Michael A. Wagner, Ganna Galitska, Bimal Paudel, Katelyn Miller & William T. Jackson
Pages: 112-125
Published online: 21 Apr 2022
AbstractforStarvation after infection restricts enterovirus D68 replication | Full Text | References | PDF (3.3 MB) | EPUB
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Open Access
Article
Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine
Shao-Ming Wang, Hsiang-En Wu, Yuko Yasui, Michal Geva, Michael Hayden, Tangui Maurice, Mauro Cozzolino & Tsung-Ping Su
Pages: 126-151
Published online: 04 May 2022
AbstractforNucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
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Article
Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells
Enrico Desideri, Serena Castelli, Coralie Dorard, Stefanie Toifl, Gian Luca Grazi, Maria Rosa Ciriolo & Manuela Baccarini
Pages: 152-162
Published online: 18 Apr 2022
AbstractforImpaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation
Hainan He, Junling Wang, Xingmei Mou, Xin Liu, Qiao Li, Mingyue Zhong, Bingbing Luo, Zhisheng Yu, Jingjing Zhang, Tian Xu, Chengli Dou, Danya Wu, Wei Qing, Linhui Wu, Kai Zhou, Zhengang Fan, Tingting Wang, Taotao Hu, Xia Zhang, Jilong Zhou & Yi-Liang Miao
Pages: 163-179
Published online: 25 Apr 2022
AbstractforSelective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins
Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen, Yu Xie, Miaojuan Ye, Ying Zhang, Xiangjun Chen, Xiaoyong Wu, Yuyao Feng, Zhi Hong, Yigang Wang, Wei Liu & Cong Yi
Pages: 180-188
Published online: 15 Apr 2022
AbstractforAtg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion
Hong Huang, Qinqin Ouyang, Kunrong Mei, Ting Liu, Qiming Sun, Wei Liu & Rong Liu
Pages: 189-203
Published online: 24 Apr 2022
AbstractforAcetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Article
Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation
Juhyung Lee, Yue Xu, Layla Saidi, Miao Xu, Konrad Zinsmaier & Yihong Ye
Pages: 204-223
Published online: 04 May 2022
AbstractforAbnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Open Access
Article
SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity
Chiao-Yin Lim, Huan-Ting Lin, Caroline Kumsta, Tzu-Chiao Lu, Feng-Yung Wang, Yun-Hsuan Kang, Malene Hansen, Tsui-Ting Ching & Ao-Lin Hsu
Pages: 224-240
Published online: 03 May 2022
AbstractforSAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Article
Proteotoxic stress disrupts epithelial integrity by inducing MTOR sequestration and autophagy overactivation
Xiaoxiang Cheng, Pei Zhang, Hongyu Zhao, Hui Zheng, Kai Zheng, Hong Zhang & Hongjie Zhang
Pages: 241-255
Published online: 06 May 2022
AbstractforProteotoxic stress disrupts epithelial integrity by inducing MTOR sequestration and autophagy overactivation | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
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Article
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis
Man J. Livingston, Shaoqun Shu, Ying Fan, Ze Li, Qiong Jiao, Xiao-Ming Yin, Manjeri A. Venkatachalam & Zheng Dong
Pages: 256-277
Published online: 18 May 2022
AbstractforTubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis | Full Text | References | PDF (9.6 MB) | EPUB | Supplemental
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Article
Vacuole fragmentation depends on a novel Atg18-containing retromer-complex
Lisa Marquardt, Matthew Taylor, Florian Kramer, Kerstin Schmitt, Gerhard H. Braus, Oliver Valerius & Michael Thumm
Pages: 278-295
Published online: 15 May 2022
AbstractforVacuole fragmentation depends on a novel Atg18-containing retromer-complex | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 3227 Views
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Brief Report

Brief Report
Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata
Rupali Gund & Angela M. Christiano
Pages: 296-305
Published online: 02 Jun 2022
AbstractforImpaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Research Paper

Article
Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis
Yunus Akkoc, Kubilay Dalci, Hacer Ezgi Karakas, Secil Erbil-Bilir, Orcun Yalav, Gurhan Sakman, Faruk Celik, Soykan Arikan, Umit Zeybek, Melek Ergin, Hikmet Akkiz, Ece Dilege, Joern Dengjel, A. Isin Dogan-Ekici & Devrim Gozuacik
Pages: 306-323
Published online: 28 Jun 2022
AbstractforTumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
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Article
Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis
G Forn-Cuní, L Welvaarts, FM Stel, CJ van den Hondel, M Arentshorst, AFJ Ram & AH Meijer
Pages: 324-337
Published online: 01 Jul 2022
AbstractforStimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 2474 Views
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Protocol

Article
Autophagy profiling in single cells with open source CellProfiler-based image analysis
David S. Schüssele, Patricia K. Haller, Maximilian L. Haas, Catherine Hunter, Katharina Sporbeck & Tassula Proikas-Cezanne
Pages: 338-351
Published online: 26 Jun 2022
AbstractforAutophagy profiling in single cells with open source CellProfiler-based image analysis | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
  • 5844 Views
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Artophagosome

Article
The world’s first (and probably last) autophagy video game
Wayne D. Hawkins, Emily R. Grush & Daniel J. Klionsky
Pages: 352-357
Published online: 16 Nov 2022
AbstractforThe world’s first (and probably last) autophagy video game | Full Text | References | PDF (3.7 MB) | EPUB
  • 874 Views
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Autophagic Punctum

Article Commentary
Actin assembly at sites of contact between the cortical ER and endocytic pits promotes ER autophagy
Dongmei Liu, Susan Ferro-Novick & Peter Novick
Pages: 358-359
Published online: 15 May 2022
AbstractforActin assembly at sites of contact between the cortical ER and endocytic pits promotes ER autophagy | Full Text | References | PDF (487.4 KB) | EPUB
  • 575 Views
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Article Commentary
N7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancer
Hui Han, Siyi Zheng & Shuibin Lin
Pages: 360-362
Published online: 23 May 2022
AbstractforN7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancer | Full Text | References | PDF (550.1 KB) | EPUB
  • 1078 Views
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Article Commentary
SQSTM1 and its MAP1LC3B-binding domain induce forced mitophagy to degrade mitochondrial carryover during mitochondrial replacement therapy
Xiao-Yan Fan, Shen Yin & Shi-Ming Luo
Pages: 363-364
Published online: 19 May 2022
AbstractforSQSTM1 and its MAP1LC3B-binding domain induce forced mitophagy to degrade mitochondrial carryover during mitochondrial replacement therapy | Full Text | References | PDF (148 KB) | EPUB
  • 643 Views
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Article Commentary
The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy
Panpan Hou, Tian Tian, Penghui Jia, Yuxin Lin, Zibo Li, Yicheng Wang, Yu Ye, Chunmei Li & Deyin Guo
Pages: 365-366
Published online: 27 May 2022
AbstractforThe regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy | Full Text | References | PDF (420.8 KB) | EPUB
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Article Commentary
VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy
Xiaoxiao Jiang, Allen Chen, Wen-Xing Ding & Hong-Min Ni
Pages: 367-369
Published online: 26 May 2022
AbstractforVMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy | Full Text | References | PDF (1.1 MB) | EPUB
  • 1304 Views
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Article Commentary
The fate of autophagosomal membrane components
Zhe Wu, Chuchu Zhou, Huilin Que, Yufen Wang & Yueguang Rong
Pages: 370-371
Published online: 02 Jun 2022
AbstractforThe fate of autophagosomal membrane components | Full Text | References | PDF (314.3 KB) | EPUB
  • 1111 Views
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Article Commentary
The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control
Bhaskar Saha & Michael A. Mandell
Pages: 372-373
Published online: 05 Jun 2022
AbstractforThe retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control | Full Text | References | PDF (341.7 KB) | EPUB
  • 788 Views
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Correction

Correction
Corrigendum
Pages: 374-375
Published online: 13 May 2022
CitationforCorrigendum | Full Text | PDF (587.6 KB) | EPUB
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