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Clinical Toxicology Volume 55, 2017 - Issue 4
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Poison Centre Research

Self-poisoning with baclofen in alcohol-dependent patients: national reports to French Poison Control Centers, 2008–2013

Fanny PelissierPoison Control Center, Toulouse-Purpan University Hospital, Toulouse, France;
,
Luc de HaroPoison Control Center, Clinical Pharmacology Department, Sainte Marguerite Hospital, Marseille, France; ;Groupe de Travail Toxicovigilance des Médicaments, ANSM, Saint Denis, France; ;Comité de Coordination de Toxicovigilance, Institut de Veille Sanitaire (InVS), Saint Maurice, France;
,
Florence CardonaGroupe de Travail Toxicovigilance des Médicaments, ANSM, Saint Denis, France; ;French National Agency for Medicines and Health Products Safety (ANSM), Saint Denis, France;
,
Cyndie PicotGroupe de Travail Toxicovigilance des Médicaments, ANSM, Saint Denis, France; ;Comité de Coordination de Toxicovigilance, Institut de Veille Sanitaire (InVS), Saint Maurice, France; ;French National Agency for Medicines and Health Products Safety (ANSM), Saint Denis, France;
,
Emmanuel PuskarczykComité de Coordination de Toxicovigilance, Institut de Veille Sanitaire (InVS), Saint Maurice, France; ;Poison Information and Toxicovigilance Center, Nancy University Medical Center, Nancy, France;
,
Jean-Marc SaporiComité de Coordination de Toxicovigilance, Institut de Veille Sanitaire (InVS), Saint Maurice, France; ;Toxicovigilance and Poison Control Center, Hospices Civils de Lyon, Lyon, France;
,
Christine TournoudGroupe de Travail Toxicovigilance des Médicaments, ANSM, Saint Denis, France; ;Comité de Coordination de Toxicovigilance, Institut de Veille Sanitaire (InVS), Saint Maurice, France; ;Poison Information and Toxicovigilance Center, Hôpital Civil, Strasbourg, France;
&
Nicolas FranchittoPoison Control Center, Toulouse-Purpan University Hospital, Toulouse, France; ;Groupe de Travail Toxicovigilance des Médicaments, ANSM, Saint Denis, France; ;Comité de Coordination de Toxicovigilance, Institut de Veille Sanitaire (InVS), Saint Maurice, France; ;Department of Addiction Medicine, Toulouse-Purpan University Hospital, Toulouse, FranceCorrespondence[email protected]
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Pages 275-284 | Received 31 May 2016, Accepted 29 Dec 2016, Published online: 03 Feb 2017

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Vincent R. Lee, Rachel M. Shively, Michael K. Connolly, Robert S. Hoffman & Joshua Nogar. (2021) Removal of baclofen with hemodialysis is negligible compared to intact kidney excretion in a pediatric overdose: a case report. Clinical Toxicology 59:3, pages 231-234.
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Kirsten C. Morley, Andrew Baillie, Wim Van Den Brink, Kate E. Chitty, Kathleen Brady, Sudie E. Back, Devanshi Seth, Greg Sutherland, Lorenzo Leggio & Paul S. Haber. (2018) N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research. Expert Opinion on Investigational Drugs 27:8, pages 667-675.
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Alain Braillon & Florian Naudet. (2018) Baclofen and the “first do not harm” motto: a new French paradox?. Clinical Toxicology 56:4, pages 307-308.
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Mariangela Antonelli, Anna Ferrulli, Luisa Sestito, Gabriele A. Vassallo, Claudia Tarli, Carolina Mosoni, Maria M. Rando, Antonio Mirijello, Antonio Gasbarrini & Giovanni Addolorato. (2018) Alcohol addiction - the safety of available approved treatment options. Expert Opinion on Drug Safety 17:2, pages 169-177.
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Mariam O. Abd el-Aziz, Ahmed H. Nadim, Hany H. Monir, M. Nebsen & Sameh E. Younis. (2023) Smartphone based colorimetric point-of-care sensor for abused drugs: case of baclofen determination in urine. BMC Chemistry 17:1.
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Jean-Marc Pelerin, Lisa Fristot, Valérie Gibaja, Bruno Revol, Pierre Gillet & Juliana Lima-Tournebize. (2023) Non-medical use of baclofen: A case series and review of the literature. Therapies 78:6, pages 615-637.
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Roberta Agabio, Rosella Saulle, Susanne Rösner & Silvia Minozzi. (2023) Baclofen for alcohol use disorder. Cochrane Database of Systematic Reviews 2023:1.
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Juan Pablo Arab, Manhal Izzy, Lorenzo Leggio, Ramon Bataller & Vijay H. Shah. (2021) Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation. Nature Reviews Gastroenterology & Hepatology 19:1, pages 45-59.
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Limon Khatun Nahar, Kevin G Murphy & Sue Paterson. (2021) Baclofen: To Screen or Not to Screen in Postmortem Blood?. Journal of Analytical Toxicology 45:6, pages 612-618.
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Mitra Rahimi, PeymanErfan Talab Evini, Yavar Yousefi & Mahbobeh Oroei. (2021) Clinical profile of patients with baclofen poisoning in an academic medical center. Journal of Reports in Pharmaceutical Sciences 10:2, pages 182.
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Caitlin N. Kent, Charlotte Park & Craig W. Lindsley. (2020) Classics in Chemical Neuroscience: Baclofen. ACS Chemical Neuroscience 11:12, pages 1740-1755.
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Laurence Labat & Bruno Mégarbane. (2019) La toxicologie du baclofène. Revue Francophone des Laboratoires 2019:517, pages 49-56.
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Lucie Chevillard, Florence Vorspan & Xavier Declèves. (2019) Le baclofène dans le traitement du trouble de l’usage d’alcool : données cliniques. Revue Francophone des Laboratoires 2019:517, pages 43-48.
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Dominique Vodovar, Hervé Laborde-Casterot, Patrick Nisse, Amélie Daveluy, Laurène Dufayet & Jérôme Langrand. (2019) Intoxications par les agonistes des récepteurs GABA : aspects pharmacologiques, toxicologiques et épidémiologiques. Revue Francophone des Laboratoires 2019:517, pages 30-35.
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Raffaele Pezzilli, Fabio Caputo, Gianni Testino, Valentino Patussi, Giovanni Greco, Livia Macciò, Maria Raffaella Rossin, Davide Mioni, Patrizia Balbinot, Claudia Gandin, Francesca Zanesini, Luca Frulloni, Sarino Aricò, Luigi C. Bottaro, Rinaldo Pellicano & Emanuele Scafato. (2019) Alcohol-related chronic exocrine pancreatic insufficiency: diagnosis and therapeutic management. A proposal for treatment by the Italian Association for the Study of the Pancreas (AISP) and the Italian Society of Alcohology (SIA). Minerva Medica 110:5.
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Renaud de Beaurepaire, Julia M. A. Sinclair, Mathis Heydtmann, Giovanni Addolorato, Henri-Jean Aubin, Esther M. Beraha, Fabio Caputo, Jonathan D. Chick, Patrick de La Selle, Nicolas Franchitto, James C. Garbutt, Paul S. Haber, Philippe Jaury, Anne R. Lingford-Hughes, Kirsten C. Morley, Christian A. Müller, Lynn Owens, Adam Pastor, Louise M. Paterson, Fanny Pélissier, Benjamin Rolland, Amanda Stafford, Andrew Thompson, Wim van den Brink, Lorenzo Leggio & Roberta Agabio. (2019) The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective. Frontiers in Psychiatry 9.
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Nazila Jamshidi, Kirsten C Morley, Rose Cairns, Andrew Dawson & Paul S Haber. (2019) A Review of Baclofen Overdoses in Australia: Calls to a Poisons Information Centre and a Case Series. Alcohol and Alcoholism 54:1, pages 73-78.
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Magali Chartier, Lucie Chevillard & Bruno Mégarbane. 2019. Neuroscience of Alcohol. Neuroscience of Alcohol 633 641 .
Florian Naudet & Alain Braillon. (2018) Baclofen and alcohol in France. The Lancet Psychiatry 5:12, pages 961-962.
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Silvia Minozzi, Rosella Saulle & Susanne Rösner. (2018) Baclofen for alcohol use disorder. Cochrane Database of Systematic Reviews 2018:11.
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Christophe Chaignot, Mahmoud Zureik, Grégoire Rey, Rosemary Dray-Spira, Joël Coste & Alain Weill. (2018) Risk of hospitalisation and death related to baclofen for alcohol use disorders: Comparison with nalmefene, acamprosate, and naltrexone in a cohort study of 165 334 patients between 2009 and 2015 in France. Pharmacoepidemiology and Drug Safety 27:11, pages 1239-1248.
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Nicolas Franchitto, Benjamin Rolland, Fanny Pelissier & Nicolas Simon. (2018) How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates. Frontiers in Psychiatry 9.
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M. Beis, A.-L. Druoton, J. Scala-Bertola, M.-J. Yehele Okouma, E. Pape, J.-M. Lalot & P.-E. Bollaert. (2018) Intoxication au baclofène et récepteurs du GABA. Médecine Intensive Réanimation 27:5, pages 475-478.
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Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane & Lucie Chevillard. (2018) Baclofen-induced encephalopathy in overdose – Modeling of the electroencephalographic effect/concentration relationships and contribution of tolerance in the rat. Progress in Neuro-Psychopharmacology and Biological Psychiatry 86, pages 131-139.
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Magali Chartier, Salma Tannous, Nadia Benturquia, Laurence Labat, Rafael Reis, Patricia Risède, Lucie Chevillard & Bruno Mégarbane. (2018) Baclofen-Induced Neuro-Respiratory Toxicity in the Rat: Contribution of Tolerance and Characterization of Withdrawal Syndrome. Toxicological Sciences 164:1, pages 153-165.
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Valentina Vengeliene, Tatiane T. Takahashi, Olga A. Dravolina, Irina Belozertseva, Edwin Zvartau, Anton Y. Bespalov & Rainer Spanagel. (2018) Efficacy and side effects of baclofen and the novel GABAB receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction. Psychopharmacology 235:7, pages 1955-1965.
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Caroline Sastre, Alice Ameline, Valérie Baillif-Couniou, Pascal Kintz, Jean-Claude Alvarez, Jean-Michel Gaulier, Delphine Allorge, Chantal Champeaux-Fesquet, Didier Pembedjoglou, Julia Torrents, Georges Léonetti & Anne-Laure Pélissier-Alicot. (2018) Concentrations post mortem de baclofène : présentation d’un cas et étude de la littérature. Toxicologie Analytique et Clinique 30:2, pages 136-141.
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Erika Bourguet, Katarzyna Ozdarska, Gautier Moroy, Jérôme Jeanblanc & Mickaël Naassila. (2017) Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). Journal of Medicinal Chemistry 61:5, pages 1745-1766.
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Maxime Léger, Marion Brunet, Gaël Le Roux, Nicolas Lerolle & David Boels. (2017) Baclofen Self-Poisoning in the Era of Changing Indication: Multicentric Reports to a French Poison Control Centre. Alcohol and Alcoholism 52:6, pages 665-670.
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Fanny Pelissier, Luc de Haro, Benjamin Rolland & Nicolas Franchitto. (2017) Severity of Baclofen Self‐Poisoning Linked to Psychiatric Co‐morbidity in Alcohol‐Dependent Patients: Better Measurement of Risk and Benefit. Basic & Clinical Pharmacology & Toxicology 121:4, pages 217-219.
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David Boels, Caroline Victorri‐Vigneau, Marie Grall‐Bronnec, Ali Touré, Anais Garnier, Alain Turcant & Gaël Le Roux. (2017) Baclofen and Alcohol‐Dependent Patients: A Real Risk of Severe Self‐Poisoning. Basic & Clinical Pharmacology & Toxicology 121:4, pages 353-359.
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N. Franchitto. (2017) Les intoxications par les médicaments addictolytiques chez le patient dépendant : focus sur le baclofène. Toxicologie Analytique et Clinique 29:2, pages S27-S28.
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