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Clinical Toxicology Volume 56, 2018 - Issue 6
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Clinical Research

The safety of high-dose insulin euglycaemia therapy in toxin-induced cardiac toxicity

Colin B. PageClinical Toxicology Research Group, University of Newcastle, Newcastle, Australia; ;School of Medicine, University of Queensland, Brisbane, Australia; ;Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, AustraliaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6924-8130
ORCID Icon,
Nicole M. RyanClinical Toxicology Research Group, University of Newcastle, Newcastle, Australia; ORCID Iconhttp://orcid.org/0000-0003-0334-1938
ORCID Icon &
Geoffrey K. IsbisterClinical Toxicology Research Group, University of Newcastle, Newcastle, Australia; ;Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, AustraliaORCID Iconhttp://orcid.org/0000-0003-1519-7419
ORCID Icon
Pages 389-396 | Received 26 Jun 2017, Accepted 09 Oct 2017, Published online: 26 Oct 2017

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Jon B. Cole, Samantha C. Lee, Matthew E. Prekker, Nathan M. Kunzler, Kelly A. Considine, Brian E. Driver, Michael A. Puskarich & Travis D. Olives. (2022) Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines. Clinical Toxicology 60:11, pages 1205-1213.
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Darren M. Roberts, Haddijatou K. Hughes, Paul S. Haber & Graham R. D. Jones. (2022) Variability in insulin pharmacokinetics following high-dose insulin therapy. Clinical Toxicology 60:3, pages 389-391.
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Andrew Kozman, Kerry Hoggett & Jessamine Soderstrom. (2021) Life threatening hypokalaemia during treatment of severe diltiazem overdose with high dose insulin euglycemic therapy: a case report. Toxicology Communications 5:1, pages 140-142.
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Joe-Anthony Rotella, Shaun L. Greene, Zeff Koutsogiannis, Andis Graudins, Yit Hung Leang, Kelvin Kuan, Helen Baxter, Elyssia Bourke & Anselm Wong. (2020) Treatment for beta-blocker poisoning: a systematic review. Clinical Toxicology 58:10, pages 943-983.
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Articles from other publishers (14)

Charlotte E Goldfine, Andrew Troger, Timothy B Erickson & Peter R Chai. (2023) Beta-blocker and calcium-channel blocker toxicity: current evidence on evaluation and management. European Heart Journal: Acute Cardiovascular Care.
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Eric J. Lavonas, Peter D. Akpunonu, Ann M. Arens, Kavita M. Babu, Dazhe Cao, Robert S. Hoffman, Christopher O. Hoyte, Maryann E. Mazer-Amirshahi, Andrew Stolbach, Maude St-Onge, Trevonne M. Thompson, George Sam Wang, Amber V. Hoover & Ian R. Drennan. (2023) 2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation.
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Patrick Bradley. (2023) THIAMINE AND HIGH DOSE INSULIN TREATMENT FOR SEPSIS. Central Asian Journal of Medical Hypotheses and Ethics 4:2, pages 77-88.
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Saskia J. Rietjens, Tessa E. van Riemsdijk, Maaike A. Sikma & Dylan W. de Lange. (2023) High‐dose insulin should NOT be used without vasopressors in calcium channel blocker toxicity. British Journal of Clinical Pharmacology 89:4, pages 1275-1278.
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Bruno Mégarbane. (2023) High‐dose insulin should be used before vasopressors/inotropes in calcium‐channel blocker toxicity. British Journal of Clinical Pharmacology 89:4, pages 1269-1274.
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Kartik R. Shah, Thomas M. Przybysz, Deepu Ushakumari & Ann-Jeannette Geib. (2022) High dose insulin therapy for inotropic support during veno-arterial extracorporeal membrane oxygenation decannulation: A case report. Medicine 101:34, pages e30267.
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Jon B. Cole & Ann M. Arens. (2022) Cardiotoxic Medication Poisoning. Emergency Medicine Clinics of North America 40:2, pages 395-416.
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Rachel F Schult, Nicholas Nacca, Tori L Grannell, Rachel M Jorgensen & Nicole M Acquisto. (2022) Evaluation of high-dose insulin/euglycemia therapy for suspected β-blocker or calcium channel blocker overdose following guideline implementation. American Journal of Health-System Pharmacy 79:7, pages 547-555.
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Justin N. Corcoran, Katherine J. Jacoby, Travis D. Olives, Stacey A. Bangh & Jon B. Cole. (2020) Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report. Journal of Medical Toxicology 16:4, pages 465-469.
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Thomas Chad, Marco Ulla, Vanesa Garnelo Rey & Carlos Gómez. (2020) High-Dose Insulin for Toxin Induced Cardiogenic Shock: Experience at a New High and Overview of the Evidence. The Journal of Emergency Medicine 58:2, pages 317-323.
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Gabrielle L. Procopio, Ruchi Patel & Amit Gupta. (2019) Clinical Pearls in Medical Toxicology: Updates Ranging From Decontamination to Elimination. Journal of Pharmacy Practice 32:3, pages 339-346.
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G. Hackl. (2019) Akute Intoxikationen: Marker für Screening, Diagnose und TherapiesteuerungAcute intoxications: markers for screening, diagnosis and therapy monitoring. Medizinische Klinik - Intensivmedizin und Notfallmedizin 114:4, pages 302-312.
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Andrew Calzadilla, Amit Badiye, Ali Ghodsizad, Jeffrey Bernstein, Michael Campos & Mehdi Mirsaeidi. (2018) A Young Woman with Bradycardia and Hypotension. Annals of the American Thoracic Society 15:9, pages 1092-1095.
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. (2018) Multiple drugs. Reactions Weekly 1708:1, pages 235-235.
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