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Clinical Research

High-dose immunosuppression to prevent death after paraquat self-poisoning – a randomised controlled trial

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Pages 633-639 | Received 22 Jul 2017, Accepted 25 Sep 2017, Published online: 03 Nov 2017

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Eileen Deuster, John A. Tomenson, Fahim Mohamed, Indika Gawarammana, Nicholas A. Buckley, Martin F. Wilks & Michael Eddleston. (2023) Dose ingested, vomiting, and outcome in patients ingesting a standard paraquat 20SL formulation. Clinical Toxicology 61:1, pages 29-38.
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Michael Eddleston, Hiroshi Nagami, Chien-Yu Lin, Mark L. Davis & Shu-Sen Chang. (2022) Pesticide use, agricultural outputs, and pesticide poisoning deaths in Japan. Clinical Toxicology 60:8, pages 933-941.
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Firouzeh Noghrehchi, Andrew H. Dawson, Jacques E. Raubenheimer & Nicholas A. Buckley. (2022) Role of age-sex as underlying risk factors for death in acute pesticide self-poisoning: a prospective cohort study. Clinical Toxicology 60:2, pages 184-190.
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Articles from other publishers (23)

Bita Anvari. (2023) Opinion: “High-Dose Immunosuppression to Prevent Death after Paraquat Self-Poisoning”- Under Estimation of a Significant Effect with Small Mortality Rate Reduction. Current Rheumatology Reviews 19:3, pages 244-245.
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Stacey E. Anderson, Courtney E. W. Sulentic & Barbara L. F. Kaplan. 2003. Patty's Toxicology. Patty's Toxicology 1 55 .
Xianbo Liu, He Yang & Zhenning Liu. (2022) Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs. International Immunopharmacology 113, pages 109301.
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Nastaran Eizadi-Mood, Danial Jaberi, Zahra Barouti, Alireza Rahimi, Marjan Mansourian, Gholamali Dorooshi, AliMohammad Sabzghabaee & Sam Alfred. (2022) The efficacy of hemodialysis on paraquat poisoning mortality: A systematic review and meta-analysis. Journal of Research in Medical Sciences 27:1, pages 74.
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Chun‐Kuei Chen, Ying‐Tse Yeh, Bruno Mégarbane, Yen‐Chia Chen, Kuan‐Fu Chen, Chia‐Hsun Chang & Chih‐Chuan Lin. (2021) A novel flowchart to predict mortality and analyse effectiveness of routinely used pharmacological regimens in paraquat poisoning. Basic & Clinical Pharmacology & Toxicology 129:6, pages 496-503.
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Jin Qian, Chun-Yuan Wu, Dong-Ming Wu, Li-Hua Li, Qi Li, Tang Deng, Qi-Feng Huang, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Zi-Yi Cheng, Chuan-Zhu Lv & Xiao-Ran Liu. (2021) Anthrahydroquinone-2-6-disulfonate is a novel, powerful antidote for paraquat poisoning. Scientific Reports 11:1.
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М.Г. Проданчук, Г.М. Балан, О.П. Кравчук, П.Г. Жмінько, І.М. Максимчук & Н.П. Чермних. (2021) До обґрунтування переліку небезпечних високотоксичних хімічних речовин, які підлягають особливому контролю щодо обігу, зберігання, використання та утилізації. Частина ІІІ (дипіридилові гербіциди паракват і дикват). Ukrainian Journal of Modern Toxicological Aspects 91:2, pages 31-40.
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M.G. Prodanchuk, G.M. Balan, O.P. Kravchuk, P.G. Zhminko, I.M. Maksymchuk & N.P. Chermnykh. (2021) To substantiation of the list of hazardous highly toxic chemicals that are subject to special control regarding handling, storage, use and disposal. Part III (bipyridyl herbicides paraquat and diquat). Ukrainian Journal of Modern Toxicological Aspects 91:2, pages 22-30.
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Luying Ryan Li, Bhuwan Chaudhary, Chao You, Jane A Dennis & Helen Wakeford. (2021) Glucocorticoid with cyclophosphamide for oral paraquat poisoning. Cochrane Database of Systematic Reviews 2021:6.
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Nicholas A Buckley, Mohamed Fahim, Jacques Raubenheimer, Indika B Gawarammana, Michael Eddleston, Michael S Roberts & Andrew H Dawson. (2021) Case fatality of agricultural pesticides after self-poisoning in Sri Lanka: a prospective cohort study. The Lancet Global Health 9:6, pages e854-e862.
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Mukul Sharma, Manas Ranjan Sahu, Biplab Rath, Tony Joseph & Kimi Soumya Padhy. (2021) Clinical and pathological profile of paraquat poisoning cases - A cross-sectional study in Odisha, India. Indian Journal of Forensic and Community Medicine 7:4, pages 210-215.
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Xin-Hong Lin, Hsiu-Yung Pan, Fu-Jen Cheng, Kuo-Chen Huang, Chao-Jui Li, Chien-Chih Chen & Po-Chun Chuang. (2021) Association between liberal oxygen therapy and mortality in patients with paraquat poisoning: A multi-center retrospective cohort study. PLOS ONE 16:1, pages e0245363.
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Maria A. Montoya-Giraldo, Luisa F. Díaz, Ubier E. Gómez, Juliana Quintero & Andres F. Zuluaga. (2020) Use of low-molecular-weight heparin in severe paraquat poisoning: a case report. Journal of Medical Case Reports 14:1.
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Yanxia Gao, Linlin Hou, Yibo Wang, Shigong Guo, Ding Yuan, Ya’nan Jiang, Guoyu Duan, Yan Zhang, Zhigao Xu, Lu Che, Changhua Sun, Sujuan Li, Shoutao Zhang, Tongwen Sun & Yi Li. (2020) Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress. Environmental Toxicology and Pharmacology 80, pages 103456.
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R Ravichandran, Deepak Amalnath, Kusa K Shaha & BH Srinivas. (2011) Paraquat Poisoning: A Retrospective Study of 55 Patients From a Tertiary Care Center in Southern India. Indian Journal of Critical Care Medicine 24:3, pages 155-159.
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Yan-Xia Gao, Yi-Bo Wang, You-Dong Wan, Tong-Wen Sun, Yi Li, Lin-Lin Hou, Pei Sun, Ding Yuan, Guo-Yu Duan, Chang-Hua Sun, Lu Che & Yan Zhang. (2020) Immunosuppressive drugs to reduce the mortality rate in patients with moderate to severe paraquat poisoning: A Meta-analysis. The Journal of Toxicological Sciences 45:3, pages 163-175.
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Meichen Wang, Asuka A. Orr, Shujun He, Chimeddulam Dalaijamts, Weihsueh A. Chiu, Phanourios Tamamis & Timothy D. Phillips. (2019) Montmorillonites Can Tightly Bind Glyphosate and Paraquat Reducing Toxin Exposures and Toxicity. ACS Omega 4:18, pages 17702-17713.
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Y Gao, S Guo, Y Wang, S Yu, M Wang, X Lu & Y Li. (2019) Lymphocyte and its CD4+ and CD8+ subgroup changes after paraquat poisoning. Human & Experimental Toxicology 38:9, pages 1024-1030.
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Xiangjun Zhang, Qiaoxian Huang, Zhe-Ze Zhao, Xiaoqiu Xu, Shengke Li, Hang Yin, Lanlan Li, Jianxiang Zhang & Ruibing Wang. (2019) An Eco- and User-Friendly Herbicide. Journal of Agricultural and Food Chemistry 67:28, pages 7783-7792.
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Yong Zhao, Ya Qi Song, Jie Gao, Shun Yi Feng & Yong Li. (2019) Monocytes as an Early Predictor for Patients with Acute Paraquat Poisoning: A Retrospective Analysis. BioMed Research International 2019, pages 1-7.
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Ying-ge Xu & Yuan-qiang Lu. (2019) Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning关于免疫抑制冲击治疗百草枯中毒的安全性和有效性评价系统回顾和荟萃分析. Journal of Zhejiang University-SCIENCE B 20:7, pages 588-597.
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Congcong Wen, Feiyan Lin, Binge Huang, Zhiguang Zhang, Xianqin Wang, Jianshe Ma, Guanyang Lin, Huiling Chen & Lufeng Hu. (2019) Metabolomics Analysis in Acute Paraquat Poisoning Patients Based on UPLC-Q-TOF-MS and Machine Learning Approach. Chemical Research in Toxicology 32:4, pages 629-637.
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Valery Lavergne, Sophie Gosselin, Marc Ghannoum, Lotte C Hoegberg & Darren M Roberts. (2018) Extracorporeal blood purification for treating acute paraquat poisoning. Cochrane Database of Systematic Reviews.
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