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Clinical Toxicology Volume 58, 2020 - Issue 12
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Review

Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review

Michael E. MullinsSection of Medical Toxicology, Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8605-0217
ORCID Icon,
Lauren H. YeagerSchool of Medicine, Bernard Becker Medical Library Medicine, Washington University, St. Louis, Missouri, USA
&
William E. FreemanSection of Medical Toxicology, Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
Pages 1284-1296 | Received 31 Mar 2020, Accepted 15 Jul 2020, Published online: 07 Aug 2020

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Michael Chary, Caroline Vizzi & Xavier Jimenez. (2023) Delayed antidotal fomepizole in massive acetaminophen overdose: a case report. Toxicology Communications 7:1.
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Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Slobodan M. Janković. (2022) Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. Expert Opinion on Drug Metabolism & Toxicology 18:11, pages 745-753.
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Ari B. Filip, Sarah E. Berg, Michael E. Mullins & Evan S. Schwarz. (2022) Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015–2020. Clinical Toxicology 60:9, pages 1006-1011.
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Stephanie L. Link, Garrett Rampon, Stephen Osmon, Anthony J. Scalzo & Barry H. Rumack. (2022) Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:4, pages 472-477.
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Articles from other publishers (10)

Qing Yao, Yingying Tang, Sheng Dai, Lihui Huang, Zewei Jiang, Shiming Zheng, Meng Sun, Yitianhe Xu, Ruijie Lu, Tuyue Sun, Huirong Huang, Xinyu Jiang, Xiaomin Yao, Guangyong Lin, Longfa Kou & Ruijie Chen. (2023) A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS. Advanced Healthcare Materials.
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James W. Dear. (2022) Fomepizole should not be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 599-601.
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Ari B. Filip & Michael E. Mullins. (2022) Fomepizole should be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 594-598.
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D. Nicholas Bateman. (2022) Large paracetamol overdose—Higher dose acetylcysteine is required. British Journal of Clinical Pharmacology 89:1, pages 34-38.
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A. Yu. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, V. V. Kulabuhov, N. Y. Stolbova & A. E. Klyuev. (2022) On the Treatment of Acute Poisoning With Paracetamol. Russian Sklifosovsky Journal "Emergency Medical Care" 11:2, pages 249-257.
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Mirjana Stanić Benić, Lana Nežić, Vesna Vujić-Aleksić & Liliana Mititelu-Tartau. (2022) Novel Therapies for the Treatment of Drug-Induced Liver Injury: A Systematic Review. Frontiers in Pharmacology 12.
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Ali Mohammad Pourbagher-Shahri, Jonathan Schimmel, Farshad M. Shirazi, Samaneh Nakhaee & Omid Mehrpour. (2022) Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. Toxicology Letters 355, pages 47-61.
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Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
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Valentina Bernal, Liliana Giraldo & Juan Carlos Moreno-Piraján. (2021) Understanding the solid-liquid equilibria between paracetamol and activated carbon: Thermodynamic approach of the interactions adsorbent-adsorbate using equilibrium, kinetic and calorimetry data. Journal of Hazardous Materials 419, pages 126432.
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Michael H. Chiu, Natalia Jaworska, Nicholas L. Li & Mark Yarema. (2021) Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis. Case Reports in Critical Care 2021, pages 1-5.
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