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Clinical Toxicology Volume 60, 2022 - Issue 4
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Poison Centre Research

Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion

J. C. Lewisa Sacramento Division, California Poison Control System, Sacramento, CA, USA;b University of California San Francisco School of Pharmacy, San Francisco, CA, USA;c Department of Internal Medicine, University of California Davis Health, Sacramento, CA, USACorrespondence[email protected]
,
M. Limd Department of Pharmacy Services, University of California Davis Health, Sacramento, CA, USA
,
L. Laia Sacramento Division, California Poison Control System, Sacramento, CA, USA
,
E. Mendozab University of California San Francisco School of Pharmacy, San Francisco, CA, USA
,
T. E. Albertsona Sacramento Division, California Poison Control System, Sacramento, CA, USA;b University of California San Francisco School of Pharmacy, San Francisco, CA, USA;c Department of Internal Medicine, University of California Davis Health, Sacramento, CA, USA
&
J. A. Chenowetha Sacramento Division, California Poison Control System, Sacramento, CA, USA;e Department of Emergency Medicine, University of California Davis Health, Sacramento, CA, USA
Pages 507-513 | Received 06 Jul 2021, Accepted 17 Sep 2021, Published online: 28 Sep 2021

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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Kartik R. Shah & Michael C. Beuhler. (2022) Authors’ reply to Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clinical Toxicology 60:5, pages 663-664.
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Sarah E. Hodgson & Anselm Wong. (2022) Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clinical Toxicology 60:5, pages 662-663.
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Articles from other publishers (6)

H. K. Ruben Thanacoody. (2022) Large paracetamol overdose – Higher dose NAC is NOT required. British Journal of Clinical Pharmacology 89:1, pages 39-42.
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Madison G. Tanner & Jacqueline D. Silva. 2023. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Yadi Zhong, Yingjian Chen, Zhisen Pan, Kaijia Tang, Guangcheng Zhong, Jingyi Guo, Tianqi Cui, Tianyao Li, Siwei Duan, Xiaoying Yang, Yong Gao, Qi Wang & Dong Zhang. (2022) Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress. Frontiers in Pharmacology 13.
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Kenzo Motohashi & Ruben HK Thanacoody. (2022) Toxicology in the emergency department: what's new?. British Journal of Hospital Medicine 83:9, pages 1-16.
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. (2022) Multiple drugs. Reactions Weekly 1906:1, pages 272-272.
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Rubén Rodríguez-Agudo, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Pablo Fernández-Tussy, David Fernández-Ramos, Sofía Lachiondo-Ortega, Irene González-Recio, Clàudia Gil-Pitarch, María Mercado-Gómez, Laura Morán, Maider Bizkarguenaga, Fernando Lopitz-Otsoa, Petar Petrov, Miren Bravo, Sebastiaan Martijn Van Liempd, Juan Manuel Falcon-Perez, Amaia Zabala-Letona, Arkaitz Carracedo, Jose Vicente Castell, Ramiro Jover, Luis Alfonso Martínez-Cruz, Teresa Cardoso Delgado, Francisco Javier Cubero, María Isabel Lucena, Raúl Jesús Andrade, Jon Mabe, Jorge Simón & María Luz Martínez-Chantar. (2022) Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen. Antioxidants 11:5, pages 897.
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