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Research Article

Efficacy of Hydroxocobalamin for the Treatment of Acute Cyanide Poisoning in Adult Beagle Dogs

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Pages 5-15 | Received 04 May 2006, Accepted 11 May 2006, Published online: 20 Oct 2008

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D. S. Lippner, D. M. Hildenberger, M. O. Rhoomes, J. N. Winborn, H. Dixon, J. McDonough & G. A. Rockwood. (2022) A novel aqueous dimethyl trisulfide formulation is effective at low doses against cyanide toxicity in non-anesthetized mice and rats. Clinical Toxicology 60:1, pages 83-94.
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Adrian Thompson, Michael Dunn, Robert D Jefferson, Kosala Dissanayake, Frances Reed, Rachael Gregson, Stephen Greenhalgh, R Eddie Clutton, Peter G Blain, Simon HL Thomas & Michael Eddleston. (2020) Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning. Clinical Toxicology 58:3, pages 190-200.
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Ilona Petrikovics, Lóránd Kiss, Ching-En Chou, Afshin Ebrahimpour, Kristóf Kovács, Márton Kiss, Brian Logue, Adriano Chan, Ananda B. W. Manage, Marianna Budai, Gerry R. Boss & Gary A. Rockwood. (2019) Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives. Toxicology Mechanisms and Methods 29:6, pages 438-444.
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Gary A. Rockwood. (2019) A bona fide need for a non-intravenous cyanide medical countermeasure. Clinical Toxicology 57:4, pages 300-300.
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Vijay K. Singh, Melissa Garcia, Stephen Y. Wise & Thomas M. Seed. (2016) Medical countermeasures for unwanted CBRN exposures: Part I chemical and biological threats with review of recent countermeasure patents. Expert Opinion on Therapeutic Patents 26:12, pages 1431-1447.
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Todd F Huzar, Tonya George & James M Cross. (2013) Carbon monoxide and cyanide toxicity: etiology, pathophysiology and treatment in inhalation injury. Expert Review of Respiratory Medicine 7:2, pages 159-170.
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John P. Thompson & Timothy C. Marrs. (2012) Hydroxocobalamin in cyanide poisoning. Clinical Toxicology 50:10, pages 875-885.
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Adriano Chan, Daune L. Crankshaw, Alexandre Monteil, Steven E. Patterson, Herbert T. Nagasawa, Jackie E. Briggs, Joseph A. Kozocas, Sari B. Mahon, Matthew Brenner, Renate B. Pilz, Timothy D. Bigby & Gerry R. Boss. (2011) The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clinical Toxicology 49:5, pages 366-373.
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Alan H. Hall, Jane Saiers & Frédéric Baud. (2009) Which cyanide antidote?. Critical Reviews in Toxicology 39:7, pages 541-552.
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Kurt Denninghoff, Frank Gardner Walter, A.J. Langa, Yao He & Russell A. Chipman. (2008) Spectrophotometry of hydroxocobalamin and hemoglobin reveals production of an unanticipated methemoglobin variant. Clinical Toxicology 46:6, pages 545-550.
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Wolfgang Uhl, Arno Nolting, Dieter Gallemann, Stefan Hecht & Andreas Kovar. (2008) Changes in blood pressure after administration of hydroxocobalamin: Relationship to changes in plasma cobalamins-(III) concentrations in healthy volunteers. Clinical Toxicology 46:6, pages 551-559.
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Pablo Díaz-Rueda, Laura Morales de los Ríos, Luis C Romero & Irene García. (2023) Old poisons, new signaling molecules: the case of hydrogen cyanide. Journal of Experimental Botany.
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Edric Wong, Nicholas Dodson, Sam Wagner & Stephen Thornton. (2022) Time to Burn? Characteristics of Hydroxocobalamin Administration in an Academic Medical Center. Journal of Pharmacy Practice, pages 089719002211366.
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Maureen A. McMichael, Melissa Singletary & Benson T. Akingbemi. (2022) Toxidromes for Working Dogs. Frontiers in Veterinary Science 9.
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Indika K. Warnakula, Afshin Ebrahimpour, Sun Yi Li, Ramesha D. Gaspe Ralalage, Chathuranga C. Hewa-Rahinduwage, Márton Kiss, Christian T. Rios, Kyler D. Kelley, Ashley C. Whiteman, David E. Thompson, Gary A. Rockwood & Ilona Petrikovics. (2020) Evaluation of the Long-Term Storage Stability of the Cyanide Antidote: Dimethyl Trisulfide and Degradation Product Identification. ACS Omega 5:42, pages 27171-27179.
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Obed A. Gyamfi, Nesta Bortey-Sam, Sari B. Mahon, Matthew Brenner, Gary A. Rockwood & Brian A. Logue. (2019) Metabolism of Cyanide by Glutathione To Produce the Novel Cyanide Metabolite 2-Aminothiazoline-4-oxoaminoethanoic Acid. Chemical Research in Toxicology 32:4, pages 718-726.
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Alexander D. Shapeton, Feroze Mahmood & Jamel P. Ortoleva. (2019) Hydroxocobalamin for the Treatment of Vasoplegia: A Review of Current Literature and Considerations for Use. Journal of Cardiothoracic and Vascular Anesthesia 33:4, pages 894-901.
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Bryant M. Moeller, Daune L. Crankshaw, Jacquie Briggs, Herbert T. Nagasawa & Steven E. Patterson. (2017) In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals. Toxicology Letters 274, pages 64-68.
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Gary A Rockwood, David E Thompson & Ilona Petrikovics. (2016) Dimethyl trisulfide. Toxicology and Industrial Health 32:12, pages 2009-2016.
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Bruno M?garbane. (2016) Hydroxocobalamin-attributed risk of oxalate nephropathy: evidence is not sufficient to change the recommended management of cyanide toxicity by fire smoke inhalation. Intensive Care Medicine 42:7, pages 1197-1198.
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Deepthika De Silva, Steven Lee, Anna Duke, Siva Angalakurthi, Ching-En Chou, Afshin Ebrahimpour, David E. Thompson & Ilona Petrikovics. (2016) Intravascular Residence Time Determination for the Cyanide Antidote Dimethyl Trisulfide in Rat by Using Liquid-Liquid Extraction Coupled with High Performance Liquid Chromatography. Journal of Analytical Methods in Chemistry 2016, pages 1-6.
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