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Research Article

Safety of Hydroxocobalamin in Healthy Volunteers in a Randomized, Placebo-Controlled Study

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Pages 17-28 | Received 27 Apr 2006, Accepted 17 May 2006, Published online: 20 Oct 2008

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Craig B Barraclough. (2015) Is There An Ideal Prehospital Drug Treatment for Acute Cyanide Poisoning?. Australasian Journal of Paramedicine 12, pages 1-7.
Crossref
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Crossref
Janice E. Sullivan & Mark J. McDonald. 2014. Pediatric Critical Care Medicine. Pediatric Critical Care Medicine 695 727 .
K. Hruby. (2013) Antidote in der klinischen ToxikologieAntidotes in clinical toxicology. Medizinische Klinik - Intensivmedizin und Notfallmedizin 108:6, pages 465-470.
Crossref
I.Vaz Matos, E. Castejón, S. Meavilla, M. O'Callaghan, J. Garcia-Villoria, A. López-Sala, A. Ribes, R. Artuch & A. Garcia-Cazorla. (2013) Clinical and biochemical outcome after hydroxocobalamin dose escalation in a series of patients with cobalamin C deficiency. Molecular Genetics and Metabolism 109:4, pages 360-365.
Crossref
Thomas Kunisaki & Steven A. Godwin. 2013. Emergency Medicine. Emergency Medicine 1178 1181.e1 .
Frédéric Baud, Philippe Hantson & Hafedh ThabetF. J. Baud. 2013. Intoxications aiguës. Intoxications aiguës 237 252 .
Ingrid KohlstadtAlan Vinitsky & Ronald Parks. 2012. Advancing Medicine with Food and Nutrients, Second Edition. Advancing Medicine with Food and Nutrients, Second Edition 595 614 .
Michael C Reade, Suzanne R Davies, Peter T Morley, Jennifer Dennett & Ian C Jacobs. (2012) Review article: Management of cyanide poisoning. Emergency Medicine Australasia 24:3, pages 225-238.
Crossref
Jeanna M. MarraffaVictor CohenMary Ann Howland. (2012) Antidotes for toxicological emergencies: A practical review. American Journal of Health-System Pharmacy 69:3, pages 199-212.
Crossref
Ensign Joseph D. Roderique, Abel A. Gebre-Giorgis, Dane H. Stewart, Michael J. Feldman & Andrea L. Pozez. (2012) Smoke Inhalation Injury in a Pregnant Patient. Journal of Burn Care & Research 33:5, pages 624-633.
Crossref
Daniel J. O’Brien, Donald W. Walsh, Colleen M. Terriff & Alan H. Hall. (2011) Empiric Management of Cyanide Toxicity Associated with Smoke Inhalation. Prehospital and Disaster Medicine 26:5, pages 374-382.
Crossref
Joseph Abdelmalek, Stephen Thornton, John Nizar, Aaron Schneir & Amber P. Sanchez. (2011) Successful use of continuous renal replacement therapy after hydroxocobalamin administration. Dialysis & Transplantation 40:9, pages 415-417.
Crossref
Jillian Hamel. (2011) A Review of Acute Cyanide Poisoning With a Treatment Update. Critical Care Nurse 31:1, pages 72-82.
Crossref
A. Dueñas-Laita, G. Burillo Putze, J.R. Alonso, A. Bajo, B. Climent, E. Corral, F. Felices, A. Ferrer, M.P. Hernández Frutos, S. Nogué & J. Puiguriguer. (2010) Bases del manejo clínico de la intoxicación por humo de incendios «Docohumo Madrid 2010». Medicina Intensiva 34:9, pages 609-619.
Crossref
Nuria Carrillo‐Carrasco & Charles P. Venditti. (2010) Response to: Hydroxocobalamin for cobalamin C: which dosage? by V. Wiwanitkit. Journal of Inherited Metabolic Disease 33:4, pages 455-455.
Crossref
Mark Sutter, Nadia Tereshchenko, Rokhsara Rafii & G. Patrick Daubert. (2010) Hemodialysis Complications of Hydroxocobalamin: A Case Report. Journal of Medical Toxicology 6:2, pages 165-167.
Crossref
N. Carrillo‐Carrasco, J. Sloan, D. Valle, A. Hamosh & C. P. Venditti. (2009) Hydroxocobalamin dose escalation improves metabolic control in cblC. Journal of Inherited Metabolic Disease 32:6, pages 728-731.
Crossref
Stephen W. Borron, Juan C. Arias, Charles R. Bauer, Michael Sanchez, Miguel Fernández & Inkyung Jung. (2009) Hemodynamics after intraosseous administration of hydroxocobalamin or normal saline in a goat model. The American Journal of Emergency Medicine 27:9, pages 1065-1071.
Crossref
Bryan Ballantyne. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Bryan Ballantyne. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Greene Shepherd & Larissa I Velez. (2008) Role of Hydroxocobalamin in Acute Cyanide Poisoning. Annals of Pharmacotherapy 42:5, pages 661-669.
Crossref
Karrie R. Jones. (2008) Hydroxocobalamin (Cyanokit). Advanced Emergency Nursing Journal 30:2, pages 112-121.
Crossref
Fr?d?ric J. Baud & Stephen W. Borron. (2008) In reply. Annals of Emergency Medicine 51:1, pages 108-109.
Crossref
F. Baud. (2008) Intoxications par les fumées d'incendie. EMC - Pathologie professionnelle et de l 'environnement 3:1, pages 1-14.
Crossref
Harry Salem & Bryan Ballantyne. 2007. Chemical Warfare Agents. Chemical Warfare Agents.
Andrew R. Erdman. (2007) Is Hydroxocobalamin Safe and Effective for Smoke Inhalation? Searching for Guidance in the Haze. Annals of Emergency Medicine 49:6, pages 814-816.
Crossref
Stephen W. Borron, Frédéric J. Baud, Patrick Barriot, Michel Imbert & Chantal Bismuth. (2007) Prospective Study of Hydroxocobalamin for Acute Cyanide Poisoning in Smoke Inhalation. Annals of Emergency Medicine 49:6, pages 794-801.e2.
Crossref
Alan H. Hall, Richard Dart & Gregory Bogdan. (2007) Sodium Thiosulfate or Hydroxocobalamin for the Empiric Treatment of Cyanide Poisoning?. Annals of Emergency Medicine 49:6, pages 806-813.
Crossref
Stephen W. Borron, Fr?d?ric J. Baud, Bruno M?garbane & Chantal Bismuth. (2007) Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. The American Journal of Emergency Medicine 25:5, pages 551-558.
Crossref
David T. Lawrence & Mark A. Kirk. (2007) Chemical Terrorism Attacks: Update on Antidotes. Emergency Medicine Clinics of North America 25:2, pages 567-595.
Crossref

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