837
Views
78
CrossRef citations to date
0
Altmetric
Articles

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose

, , , , &
Pages 697-702 | Received 22 May 2008, Accepted 03 Jun 2008, Published online: 20 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (17)

David S. Umbaugh & Hartmut Jaeschke. (2021) Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity. Expert Review of Gastroenterology & Hepatology 15:4, pages 363-375.
Read now
Alaa Daoud, Kim Peder Dalhoff, Mikkel Bring Christensen, Søren Bøgevig & Tonny Studsgaard Petersen. (2020) Two-bag intravenous N-acetylcysteine, antihistamine pretreatment and high plasma paracetamol levels are associated with a lower incidence of anaphylactoid reactions to N-acetylcysteine. Clinical Toxicology 58:7, pages 698-704.
Read now
Michael E. Mullins, Mary Yu, Lauren O’Grady, Shariq Khan & Evan S. Schwarz. (2020) Adverse reactions in patients treated with the one-bag method of N-acetylcysteine for acetaminophen ingestion. Toxicology Communications 4:1, pages 49-54.
Read now
Robert G. Hendrickson. (2019) What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?. Clinical Toxicology 57:8, pages 686-691.
Read now
Geoffrey K. Isbister, Michael A. Downes, Kylie Mcnamara, Ingrid Berling, Ian M. Whyte & Colin B. Page. (2016) A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning. Clinical Toxicology 54:2, pages 120-126.
Read now
K. Heard, B. H. Rumack, J. L. Green, B. Bucher-Bartelson, S. Heard, A. C. Bronstein & R. C. Dart. (2014) A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clinical Toxicology 52:5, pages 512-518.
Read now
Shazia Rahman, Brian Gilberti & Adam J. Berman. (2013) Letter in response to Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology 51:10, pages 1241-1241.
Read now
M. L. A. Sivilotti, D. N. Juurlink, J. S. Garland, I. Lenga, R. Poley, L. N. Hanly & M. Thompson. (2013) Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51:9, pages 855-863.
Read now
W Stephen Waring. (2012) Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning. Expert Review of Clinical Pharmacology 5:3, pages 311-318.
Read now
Barry H Rumack & D Nicholas Bateman. (2012) Acetaminophen and acetylcysteine dose and duration: Past, present and future. Clinical Toxicology 50:2, pages 91-98.
Read now
Wendy Klein-Schwartz & Suzanne Doyon. (2011) Intravenous acetylcysteine for the treatment of acetaminophen overdose. Expert Opinion on Pharmacotherapy 12:1, pages 119-130.
Read now
D. Nicholas Bateman & James Dear. (2010) Medicine, poison, and mystic potion: a personal perspective on paracetamol Louis Roche lecture, Stockholm, 2009. Clinical Toxicology 48:2, pages 97-103.
Read now
E.A. Sandilands & D.N. Bateman. (2009) Adverse reactions associated with acetylcysteine. Clinical Toxicology 47:2, pages 81-88.
Read now

Articles from other publishers (61)

Kyle Rodrigues, Rawdat Hussain, Sarah Cooke, Gary Zhang, Deqiang Zhang, Lei Yin & Xin Tong. (2023) Fructose as a novel nutraceutical for acetaminophen (APAP)-induced hepatotoxicity. Metabolism and Target Organ Damage 3:4.
Crossref
Guangwen Luo, Lili Huang & Zhaowei Zhang. (2023) The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. Experimental Biology and Medicine 248:5, pages 412-424.
Crossref
Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo & Tian Lan. (2023) Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation . Food & Function 14:4, pages 1884-1896.
Crossref
Zhiwei Huang, Hengcai Wang, Changju Chun, Xinze Li, Shihao Xu & Yingzheng Zhao. (2023) Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury. Frontiers in Pharmacology 13.
Crossref
Ping Wang, Yan Cui, Jing Wang, Donghua Liu, Yue Tian, Kai Liu, Xue Wang, Lin Liu, Yu He, Yufeng Pei, Li Li, Liying Sun, Zhijun Zhu, Dehua Chang, Jidong Jia & Hong You. (2022) Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor. Stem Cell Research & Therapy 13:1.
Crossref
David S. Umbaugh, Rupal P. Soder, Nga T. Nguyen, Olamide Adelusi, Dakota R. Robarts, Ben Woolbright, Luqi Duan, Sunil Abhyankar, Buddhadeb Dawn, Udayan Apte, Hartmut Jaeschke & Anup Ramachandran. (2022) Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts. Archives of Toxicology 96:12, pages 3315-3329.
Crossref
Elizabeth A. Gregory & Erin M. Binagia. (2022) Anaphylaxis due to First-Time Intravenous Infusion of N-Acetylcysteine in a Dog. Topics in Companion Animal Medicine 51, pages 100734.
Crossref
Xiaopeng Cai, Shiyuan Hua, Jingwen Deng, Zhen Du, Dongxiao Zhang, Zhenfeng Liu, Nazif Ullah Khan, Min Zhou & Zhi Chen. (2022) Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury. ACS Applied Materials & Interfaces 14:38, pages 42887-42903.
Crossref
Anna Licata, Maria Giovanna Minissale, Simona Stankevičiūtė, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J Andrade & Piero Luigi Almasio. (2022) N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review. Frontiers in Pharmacology 13.
Crossref
Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
Crossref
Brandán Pedre, Uladzimir Barayeu, Daria Ezeriņa & Tobias P. Dick. (2021) The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species. Pharmacology & Therapeutics 228, pages 107916.
Crossref
Jephte Y. Akakpo, Matthew W. Jaeschke, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2021) Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Archives of Toxicology 95:10, pages 3377-3391.
Crossref
Anup Ramachandran & Hartmut Jaeschke. (2021) Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development. Antioxidants & Redox Signaling 35:9, pages 718-733.
Crossref
Apu Chowdhury, Jahan Nabila, Isaac Adelusi Temitope & Sicen Wang. (2020) Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. Pharmacological Research 161, pages 105102.
Crossref
L. Claire Epperson, Stephanie T. Weiss & Dazhe James Cao. (2020) A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent. Journal of Medical Toxicology.
Crossref
Hartmut Jaeschke, Jephte Y Akakpo, David S Umbaugh & Anup Ramachandran. (2020) Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure. Toxicological Sciences 174:2, pages 159-167.
Crossref
D. Adam Algren. 2020. Toxicology Cases for the Clinical and Forensic Laboratory. Toxicology Cases for the Clinical and Forensic Laboratory 75 77 .
D. Nicholas Bateman & James W. Dear. (2019) Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use. Toxicology Research 8:4, pages 489-498.
Crossref
Kerry Layne, Louise Hope, Edmund Rab, John Archer, David M. Wood & Paul I. Dargan. (2018) An evaluation of the role of mixing techniques in the observed variation in acetylcysteine infusion concentrations. British Journal of Clinical Pharmacology 85:1, pages 252-257.
Crossref
Angela L. Chiew & Geoffrey K. Isbister. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 147 168 .
Romina Castañeda-Arriaga, Adriana Pérez-González & Annia Galano. (2018) Chemical Protectors against the Toxic Effects of Paracetamol (Acetaminophen) and Its Meta Analogue: Preventing Protein Arylation. ACS Omega 3:12, pages 18582-18591.
Crossref
Mohammad Adil, SyedSuhail Amin & Mohd Mohtashim. (2018) N-acetylcysteine in dermatology. Indian Journal of Dermatology, Venereology and Leprology 84:6, pages 652.
Crossref
D. Nicholas Bateman & James W. Dear. (2017) Should we treat very large paracetamol overdose differently?. British Journal of Clinical Pharmacology 83:6, pages 1163-1165.
Crossref
Tom MunyerAmberly Johnson. 2017. PharmacotherapyFirst: A Multimedia Learning Resource. PharmacotherapyFirst: A Multimedia Learning Resource.
George P. Bailey, David M. Wood, John R. H. Archer, Edmund Rab, Robert J. Flanagan & Paul I. Dargan. (2016) An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose. British Journal of Clinical Pharmacology 83:2, pages 393-399.
Crossref
Philip Moore & Keith Burkhart. 2017. Critical Care Toxicology. Critical Care Toxicology 693 739 .
D. Nicholas Bateman. 2017. Critical Care Toxicology. Critical Care Toxicology 1145 1169 .
Sa’ed H. Zyoud, W. Stephen Waring, Samah W. Al-Jabi, Waleed M. Sweileh & Rahmat Awang. (2016) The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. SpringerPlus 5:1.
Crossref
George P. Bailey, Javad Najafi, Muhammad E. M. O. Elamin, W. Stephen Waring, Simon H. L. Thomas, John R. H. Archer, David M. Wood & Paul I. Dargan. (2016) Delays during the administration of acetylcysteine for the treatment of paracetamol overdose. British Journal of Clinical Pharmacology 82:5, pages 1358-1363.
Crossref
Dagmara Szkolnicka, Baltasar Lucendo-Villarin, Joanna K. Moore, Kenneth J. Simpson, Stuart J. Forbes & David C. Hay. (2016) Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs. Stem Cells Translational Medicine 5:6, pages 764-772.
Crossref
Euan A. Sandilands, Emma E. Morrison & D. Nicholas Bateman. (2016) Adverse reactions to intravenous acetylcysteine in paracetamol poisoning. Adverse Drug Reaction Bulletin 297:1, pages 1147-1150.
Crossref
Angela L. Chiew, Geoffrey K. Isbister, Stephen B. Duffull & Nicholas A. Buckley. (2016) Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology 81:3, pages 471-481.
Crossref
Philip Moore & Keith Burkhart. 2016. Critical Care Toxicology. Critical Care Toxicology 1 47 .
D. Nicholas Bateman. 2016. Critical Care Toxicology. Critical Care Toxicology 1 25 .
SH Zyoud, SW Al-Jabi, WM Sweileh, R Awang & WS Waring. (2015) Global research productivity of N -acetylcysteine use in paracetamol overdose . Human & Experimental Toxicology 34:10, pages 1006-1016.
Crossref
D. Nicholas Bateman. (2015) Changing the Management of Paracetamol Poisoning. Clinical Therapeutics 37:9, pages 2135-2141.
Crossref
D. Nicholas Bateman. (2015) Paracetamol poisoning: beyond the nomogram. British Journal of Clinical Pharmacology 80:1, pages 45-50.
Crossref
Andis Graudins. (2015) Paracetamol poisoning in adolescents in an Australian setting: Not quite adults. Emergency Medicine Australasia 27:2, pages 139-144.
Crossref
R Carroll, J Benger, K Bramley, S Williams, L Griffin, J Potokar & D Gunnell. (2015) Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department. Emergency Medicine Journal 32:2, pages 155-160.
Crossref
D. Nicholas Bateman. 2016. Critical Care Toxicology. Critical Care Toxicology 1 25 .
D. Nicholas Bateman, Robert Carroll, Janice Pettie, Takahiro Yamamoto, Muhammad E. M. O. Elamin, Lucy Peart, Margaret Dow, Judy Coyle, Kristina R. Cranfield, Christopher Hook, Euan A. Sandilands, Aravindan Veiraiah, David Webb, Alasdair Gray, Paul I. Dargan, David M. Wood, Simon H. L. Thomas, James W. Dear & Michael Eddleston. (2014) Effect of the UK 's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment . British Journal of Clinical Pharmacology 78:3, pages 610-618.
Crossref
Shawn M. Varney, Jennie A. Buchanan, Jamie Kokko & Kennon Heard. (2014) Acetylcysteine for Acetaminophen Overdose in Patients Who Weigh >100 Kg. American Journal of Therapeutics 21:3, pages 159-163.
Crossref
Anselm Wong, Andis Graudins, Fergus Kerr & Shaun L Greene. (2014) Paracetamol toxicity: What would be the implications of a change in Australian treatment guidelines?. Emergency Medicine Australasia 26:2, pages 183-187.
Crossref
Gordon F. Rushworth & Ian L. Megson. (2014) Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacology & Therapeutics 141:2, pages 150-159.
Crossref
D Nicholas Bateman, James W Dear, H K Ruben Thanacoody, Simon H L Thomas, Michael Eddleston, Euan A Sandilands, Judy Coyle, Jamie G Cooper, Aryelly Rodriguez, Isabella Butcher, Steff C Lewis, A D Bastiaan Vliegenthart, Aravindan Veiraiah, David J Webb & Alasdair Gray. (2014) Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. The Lancet 383:9918, pages 697-704.
Crossref
H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon HL Thomas & D Nicholas Bateman. (2013) Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacology and Toxicology 14:1.
Crossref
S. S. Panesar, S. Javad, D. de Silva, B. I. Nwaru, L. Hickstein, A. Muraro, G. Roberts, M. Worm, M. B. Bilò, V. Cardona, A. E. J. Dubois, A. Dunn Galvin, P. Eigenmann, M. Fernandez-Rivas, S. Halken, G. Lack, B. Niggemann, A. F. Santos, B. J. Vlieg-Boerstra, Z. Q. Zolkipli & A. Sheikh. (2013) The epidemiology of anaphylaxis in Europe: a systematic review. Allergy 68:11, pages 1353-1361.
Crossref
Byeong Jo ChunJeong Mi MoonSeung Ho Kim. (2013) Antidote for acetaminophen poisoning: N -acetylcysteine . Journal of the Korean Medical Association 56:12, pages 1067.
Crossref
W. Stephen Waring. (2012) Novel acetylcysteine regimens for treatment of paracetamol overdose. Therapeutic Advances in Drug Safety 3:6, pages 305-315.
Crossref
David J. McQuade, Paul I. Dargan, Jeff Keep & David M. Wood. (2012) Paracetamol toxicity: what would be the implications of a change in UK treatment guidelines?. European Journal of Clinical Pharmacology 68:11, pages 1541-1547.
Crossref
Shivakumar Chitturi & Geoffrey C. Farrell. 2011. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver 703 783 .
Andrew R Elms, Kelly P Owen, Timothy E Albertson & Mark E Sutter. (2011) Fatal myocardial infarction associated with intravenous N-acetylcysteine error. International Journal of Emergency Medicine 4:1.
Crossref
Simon W. Lam, Kristin M. Engebretsen & Seth R. Bauer. (2011) Toxicology Today. Journal of Pharmacy Practice 24:2, pages 174-188.
Crossref
Sa'ed H. Zyoud, Rahmat Awang, Syed Azhar Syed Sulaiman & Samah W. Al-Jabi. (2010) Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study. Pharmacoepidemiology and Drug Safety 19:10, pages 1064-1070.
Crossref
Sa’ed H. Zyoud, Rahmat Awang, Syed Azhar Syed Sulaiman, Halilol Rahman Mohamed Khan, Ansam F. Sawalha, Waleed M. Sweileh & Samah W. Al‐Jabi. (2010) Relationship between Serum Acetaminophen Concentration and N ‐Acetylcysteine‐Induced Adverse Drug Reactions . Basic & Clinical Pharmacology & Toxicology 107:3, pages 718-723.
Crossref
Selman Yeniocak, Ozgur Tatli, Aysegul Cansu, Engin Erturk, Mehmet Muharrem Erol & Suleyman Turedi. (2010) Acute severe respiratory distress secondary to misuse of an N-acetylcysteine effervescent tablet. The American Journal of Emergency Medicine 28:7, pages 842.e5-842.e6.
Crossref
Sa'ed H Zyoud, Rahmat Awang, Syed Azhar Syed Sulaiman, Waleed M Sweileh & Samah W Al-jabi. (2010) Incidence of adverse drug reactions induced by N-acetylcysteine in patients with acetaminophen overdose. Human & Experimental Toxicology 29:3, pages 153-160.
Crossref
Craig G. Smollin. (2010) Toxicology: Pearls and Pitfalls in the Use of Antidotes. Emergency Medicine Clinics of North America 28:1, pages 149-161.
Crossref
Silas W. Smith. 2010. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 397 460 .
D. Nicholas Bateman & Timothy C. Marrs. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Mark C. Yarema, David W. Johnson, Randall J. Berlin, Marco L.A. Sivilotti, Alberto Nettel-Aguirre, Rollin F. Brant, Daniel A. Spyker, Benoit Bailey, Dominic Chalut, Jacques S. Lee, Amy C. Plint, Roy A. Purssell, Tim Rutledge, Catherine A. Seviour, Ian G. Stiell, Margaret Thompson, Jeffrey Tyberg, Richard C. Dart & Barry H. Rumack. (2009) Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning. Annals of Emergency Medicine 54:4, pages 606-614.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.