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Epigenetics Volume 10, 2015 - Issue 1
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RESEARCH PAPER

DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects

Anne RochtusDepartment of Cardiovascular Sciences; Center for Molecular and Vascular Biology; University of Leuven; Leuven, Belgium;Department of Pediatrics; University Hospitals Leuven; Leuven, Belgium
,
Benedetta IzziDepartment of Cardiovascular Sciences; Center for Molecular and Vascular Biology; University of Leuven; Leuven, Belgium
,
Elise VangeelGenetic Research About Stress and Psychiatry (GRASP); University of Leuven; Leuven, Belgium
,
Sophie LouwetteDepartment of Cardiovascular Sciences; Center for Molecular and Vascular Biology; University of Leuven; Leuven, Belgium
,
Christine WittevrongelDepartment of Cardiovascular Sciences; Center for Molecular and Vascular Biology; University of Leuven; Leuven, Belgium
,
Diether LambrechtsVesalius Research Center; VIB; Leuven, Belgium;Laboratory for Translational Genetics; Department of Oncology; University of Leuven; Leuven, Belgium
,
Yves MoreauDepartment of Electrical Engineering ESAT-SCD; University of Leuven; Leuven, Belgium
,
Raf WinandDepartment of Electrical Engineering ESAT-SCD; University of Leuven; Leuven, Belgium
,
Carla VerpoortenDepartment of Pediatrics; University Hospitals Leuven; Leuven, Belgium
,
Katrien JansenDepartment of Pediatrics; University Hospitals Leuven; Leuven, Belgium
,
Chris Van GeetDepartment of Cardiovascular Sciences; Center for Molecular and Vascular Biology; University of Leuven; Leuven, Belgium;Department of Pediatrics; University Hospitals Leuven; Leuven, Belgium
&
Kathleen FresonDepartment of Cardiovascular Sciences; Center for Molecular and Vascular Biology; University of Leuven; Leuven, BelgiumCorrespondence[email protected]
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Pages 92-101 | Received 26 Sep 2014, Accepted 07 Dec 2014, Published online: 29 Jan 2015

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Tian Tian, Xinyuan Lai, Kuanhui Xiang, Xiao Han, Shengju Yin, Robert M. Cabrera, John W. Steele, Yunping Lei, Xuanye Cao, Richard H. Finnell, Linlin Wang & Aiguo Ren. (2022) Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects. Epigenetics 17:2, pages 133-146.
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Linlin Wang, Shanshan Lin, Ji Zhang, Tian Tian, Lei Jin & Aiguo Ren. (2017) Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis. Epigenetics 12:2, pages 157-165.
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Rui Cao, Jun Xie & Li Zhang. (2022) Abnormal methylation caused by folic acid deficiency in neural tube defects. Open Life Sciences 17:1, pages 1679-1688.
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Marco Mendizábal-Castillero, Manuel Alejandro Merlo, Ismael Cross, María Esther Rodríguez & Laureana Rebordinos. (2022) Genomic Characterization of hox Genes in Senegalese Sole (Solea senegalensis, Kaup 1858): Clues to Evolutionary Path in Pleuronectiformes. Animals 12:24, pages 3586.
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Wanqi Huang, Zhengwei Yuan & Hui Gu. (2022) Exploring epigenomic mechanisms of neural tube defects using multi‐omics methods and data. Annals of the New York Academy of Sciences 1515:1, pages 50-60.
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Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li & Nicholas D. E. Greene. (2019) Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Clinical Epigenetics 11:1.
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Henan Zhang, Yi Guo, Hui Gu, Xiaowei Wei, Wei Ma, Dan Liu, Kun Yu, Wenting Luo, Ling Ma, Yusi Liu, Jia Xue, Jieting Huang, Yanfu Wang, Shanshan Jia, Naixuan Dong, Hongyan Wang & Zhengwei Yuan. (2019) TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis. Clinical Epigenetics 11:1.
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Juan Yu, Lei Wang, Pei Pei, Xue Li, Jianxin Wu, Zhiyong Qiu, Juan Zhang, Ruifang Ao, Shan Wang, Ting Zhang & Jun Xie. (2019) Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects. Epigenetics & Chromatin 12:1.
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Laura Goetzl, Tara Thompson‐Felix, Nune Darbinian, Nana Merabova, Salim Merali, Carmen Merali, Kathryne Sanserino, Tamara Tatevosian, Bruno Fant & Mathieu E Wimmer. (2019) Novel biomarkers to assess in utero effects of maternal opioid use: First steps toward understanding short‐ and long‐term neurodevelopmental sequelae. Genes, Brain and Behavior.
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Cui-Huan Tian, Jun Dai, Wei Zhang, Yan Liu & Yan Yang. (2019) Expression of IL-17 and its gene promoter methylation status are associated with the progression of chronic hepatitis B virus infection. Medicine 98:23, pages e15924.
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Tian Tian, Linlin Wang, Yan Shen, Bo Zhang, Richard H Finnell & Aiguo Ren. (2018) Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects . Epigenomics 10:7, pages 891-901.
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Anne M. Molloy. (2018) Should vitamin B 12 status be considered in assessing risk of neural tube defects? . Annals of the New York Academy of Sciences 1414:1, pages 109-125.
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J.M. Rogers, C. Lau & R.G. Ellis-Hutchings. 2018. Comprehensive Toxicology. Comprehensive Toxicology 118 136 .
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Ruiping Zhang, Lirong Cao, Yizheng Wang, Yulian Fang, Linsheng Zhao, Weidong Li, Ou-Yan Shi & Chun-Quan Cai. (2017) A unique methylation pattern co-segregates with neural tube defect statuses in Han Chinese pedigrees. Neurological Sciences 38:12, pages 2153-2164.
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Anne M. MolloyFaith PangilinanLawrence C. Brody. (2017) Genetic Risk Factors for Folate-Responsive Neural Tube Defects. Annual Review of Nutrition 37:1, pages 269-291.
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Anne Rochtus, Raf Winand, Griet Laenen, Elise Vangeel, Benedetta Izzi, Christine Wittevrongel, Yves Moreau, Carla Verpoorten, Katrien Jansen, Chris Van Geet & Kathleen Freson. (2016) Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development. Clinical Epigenetics 8:1.
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Anne Rochtus, Alejandro Martin-Trujillo, Benedetta Izzi, Francesca Elli, Intza Garin, Agnes Linglart, Giovanna Mantovani, Guiomar Perez de Nanclares, Suzanne Thiele, Brigitte Decallonne, Chris Van Geet, David Monk & Kathleen Freson. (2016) Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects. Clinical Epigenetics 8:1.
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E. Magda Price, Maria S. Peñaherrera, Elodie Portales-Casamar, Paul Pavlidis, Margot I. Van Allen, Deborah E. McFadden & Wendy P. Robinson. (2016) Profiling placental and fetal DNA methylation in human neural tube defects. Epigenetics & Chromatin 9:1.
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Fei fei Ma, Ding ding Cao, Shengrong Ouyang, Renqiao Tang, Zhuo Liu, Yuanyuan Li & Jianxin Wu. (2016) Hypermethylation of AKT2 gene is associated with neural-tube defects in fetus. Placenta 48, pages 80-86.
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Rachelle E Irwin, Kristina Pentieva, Tony Cassidy, Diane J Lees-Murdock, Marian McLaughlin, Girijesh Prasad, Helene McNulty & Colum P Walsh. (2016) The interplay between DNA methylation, folate and neurocognitive development. Epigenomics 8:6, pages 863-879.
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Dieuwertje E. G. Kok, Rosalie A. M. Dhonukshe-Rutten, Carolien Lute, Sandra G. Heil, André G. Uitterlinden, Nathalie van der Velde, Joyce B. J. van Meurs, Natasja M. van Schoor, Guido J. E. J. Hooiveld, Lisette C. P. G. M. de Groot, Ellen Kampman & Wilma T. Steegenga. (2015) The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. Clinical Epigenetics 7:1.
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E. B. Vangeel, B. Izzi, T. Hompes, K. Vansteelandt, D. Lambrechts, K. Freson & S. Claes. (2015) DNA methylation in imprinted genes IGF2 and GNASXL is associated with prenatal maternal stress . Genes, Brain and Behavior 14:8, pages 573-582.
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Zhen-Li Wang. (2015) Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B. World Journal of Gastroenterology 21:27, pages 8382.
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