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Epigenetics Volume 11, 2016 - Issue 2
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Brief Report

Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia

Thomas WilhelmDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
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Daniel B. LipkaRegulation of Cellular Differentiation Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, GermanyCorrespondence[email protected] [email protected]
,
Tania WitteDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
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Justyna A. WierzbinskaDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany;Regulation of Cellular Differentiation Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
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Silvia FluhrDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology–Oncology, University of Freiburg Medical Center, Freiburg, Germany;Hermann Staudinger Graduate School, University of Freiburg, Freiburg, Germany
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Monika HelfRegulation of Cellular Differentiation Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
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Oliver MückeDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany;Regulation of Cellular Differentiation Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
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Rainer ClausDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany;Department of Medicine, Division of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
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Carolin KonermannDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
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Peter NöllkeDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology–Oncology, University of Freiburg Medical Center, Freiburg, Germany
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Charlotte M. NiemeyerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology–Oncology, University of Freiburg Medical Center, Freiburg, Germany;German Cancer Consortium (DKTK)
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Christian FlothoDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology–Oncology, University of Freiburg Medical Center, Freiburg, Germany;German Cancer Consortium (DKTK)
&
Christoph PlassDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany;German Cancer Consortium (DKTK)Correspondence[email protected] [email protected]
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Pages 110-119 | Received 22 Jul 2015, Accepted 18 Jan 2016, Published online: 22 Mar 2016

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Christian Flotho. (2019) Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia. Epigenetics 14:3, pages 236-244.
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Xiong-yu Liao, Kun-yin Qiu, Jian-pei Fang, Ruo-hao Wu, Shu-yi Guo, Ke Huang & Dun-hua Zhou. (2019) Diagnosis and treatment of juvenile myelomonocytic leukemia. Hematology 24:1, pages 577-582.
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Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M. Niemeyer & Christian Flotho. (2017) Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia. Epigenetics 12:8, pages 715-723.
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Articles from other publishers (18)

Yilin Deng, Jinjin Gao, Guangying Xu, Yuan Yao, Yan Sun, Yehui Shi, Xishan Hao, Liling Niu & Hui Li. (2022) HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis. Cancer Letters 549, pages 215911.
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Anne Schuhn, Tania Witte Tobar, Aoife Ward Gahlawat, Jana Hauke, Lukas Baumann, Jürgen G. Okun & Juliane Nees. (2022) Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study. Archives of Gynecology and Obstetrics 306:5, pages 1623-1632.
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Claudia Fiñana, Noel Gómez-Molina, Sandra Alonso-Moreno & Laura Belver. (2022) Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia. Cancers 14:5, pages 1335.
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Min Zhou, Shasha Hong, Bingshu Li, Cheng Liu, Ming Hu, Jie Min, Jianming Tang & Li Hong. (2021) Development and Validation of a Prognostic Nomogram Based on DNA Methylation-Driven Genes for Patients With Ovarian Cancer. Frontiers in Genetics 12.
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Paula J. BuckoJohn D. Scott. (2021) Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option. Annual Review of Pharmacology and Toxicology 61:1, pages 361-379.
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Maximilian Schönung, Julia Meyer, Peter Nöllke, Adam B. Olshen, Mark Hartmann, Norihiro Murakami, Manabu Wakamatsu, Yusuke Okuno, Christoph Plass, Mignon L. Loh, Charlotte M. Niemeyer, Hideki Muramatsu, Christian Flotho, Elliot Stieglitz & Daniel B. Lipka. (2021) International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia. Clinical Cancer Research 27:1, pages 158-168.
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Sonia Meynier & Frédéric Rieux-Laucat. (2020) After 95 years, it's time to eRASe JMML. Blood Reviews 43, pages 100652.
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Andra Marcu, Andrei Colita, Letitia Elena Radu, Cristina Georgiana Jercan, Ana Maria Bica, Minodora Asan, Daniel Coriu, Alina Daniela Tanase, Carmen C. Diaconu, Cristina Mambet, Anca Botezatu, Sergiu Pasca, Patric Teodorescu, Gabriela Anton, Petruta Gurban & Anca Colita. (2020) Single-Center Experience With Epigenetic Treatment for Juvenile Myelomonocytic Leukemia. Frontiers in Oncology 10.
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Wei Qian, Fengbo Jin, Yiming Zhao, Yingying Chen, Ling Ge, Lixia Liu & Mingzhen Yang. (2020) Downregulation of microRNA-144 inhibits proliferation and promotes the apoptosis of myelodysplastic syndrome cells through the activation of the AKAP12-dependent ERK1/2 signaling pathway. Cellular Signalling 68, pages 109493.
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Charlotte M. Niemeyer & Christian Flotho. (2019) Juvenile myelomonocytic leukemia: who’s the driver at the wheel?. Blood 133:10, pages 1060-1070.
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Feng-Juan Li, Yi Wu, Qun Lv, Xue-Yuan Yang, Ming-Jun Jiang & Li-Ming Li. (2019) Aberrant DNA Methylation in Cutaneous Squamous Cell Carcinoma. International Journal of Dermatology and Venereology 2:4, pages 227-232.
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Takashi Kurata, Kazuyuki Matsuda, Koichi Hirabayashi, Tomonari Shigemura, Kazuo Sakashita, Tatsutoshi Nakahata & Kenichi Koike. (2018) Panobinostat inhibits the proliferation of CD34 + CD38 − cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia . Pediatric Blood & Cancer 65:11, pages e27261.
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Christian Flotho, Sebastian Sommer & Michael Lübbert. (2018) DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia. Seminars in Cancer Biology 51, pages 68-79.
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Ana Ortega, Estefanía Tarazón, Carolina Gil-Cayuela, Luis Martínez-Dolz, Francisca Lago, José Ramón González-Juanatey, Juan Sandoval, Manuel Portolés, Esther Roselló-Lletí & Miguel Rivera. (2018) ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end-stage heart failure patients . ESC Heart Failure 5:4, pages 732-737.
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Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik, Jens Langstein, Justyna A. Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho & Christoph Plass. (2017) RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. Nature Communications 8:1.
Crossref
Erica Reggi & Dario Diviani. (2017) The role of A-kinase anchoring proteins in cancer development. Cellular Signalling 40, pages 143-155.
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Michael W. N. Deininger, Jeffrey W. Tyner & Eric Solary. (2017) Turning the tide in myelodysplastic/myeloproliferative neoplasms. Nature Reviews Cancer 17:7, pages 425-440.
Crossref
Silvia Fluhr, Melanie Boerries, Hauke Busch, Aikaterini Symeonidi, Tania Witte, Daniel B Lipka, Oliver Mücke, Peter Nöllke, Christopher Felix Krombholz, Charlotte M Niemeyer, Christoph Plass & Christian Flotho. (2016) CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia. Clinical Epigenetics 8:1.
Crossref

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