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Epigenetics Volume 12, 2017 - Issue 2
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Research Paper

Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis

Linlin WangInstitute of Reproductive and Child Health, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, China
,
Shanshan LinInstitute of Reproductive and Child Health, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, China
,
Ji ZhangInstitute of Reproductive and Child Health, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, China
,
Tian TianInstitute of Reproductive and Child Health, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, China
,
Lei JinInstitute of Reproductive and Child Health, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, China
&
Aiguo RenInstitute of Reproductive and Child Health, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, ChinaCorrespondence[email protected]
Pages 157-165 | Received 17 Nov 2016, Accepted 22 Dec 2016, Published online: 31 Jan 2017

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Tian Tian, Xinyuan Lai, Kuanhui Xiang, Xiao Han, Shengju Yin, Robert M. Cabrera, John W. Steele, Yunping Lei, Xuanye Cao, Richard H. Finnell, Linlin Wang & Aiguo Ren. (2022) Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects. Epigenetics 17:2, pages 133-146.
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Yun Huang, Shanshan Lin, Lei Jin, Linlin Wang & Aiguo Ren. (2019) Decreased global DNA hydroxymethylation in neural tube defects: Association with polycyclic aromatic hydrocarbons. Epigenetics 14:10, pages 1019-1029.
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Articles from other publishers (16)

Carlo Donato Caiaffa, Cristiane Sá Roriz Fonteles, Lei Yunping & Richard H. Finnell. 2023. Gene-Environment Interactions in Birth Defects and Developmental Disorders. Gene-Environment Interactions in Birth Defects and Developmental Disorders 193 220 .
Yuejiao Ma, Weitao Zhang, Weihong Li, Xin Lu, Yaqiong Li, Xueya Han, Ping Wang & Haiyan Zhang. (2022) α5 integrin regulates hepatic tight junctions through SRC-TET1-mediated DNA hydroxymethylation. iScience 25:12, pages 105611.
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Durgesh Nandini Das & Nathan Ravi. (2022) Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment. Environmental Research 213, pages 113677.
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Wanqi Huang, Zhengwei Yuan & Hui Gu. (2022) Exploring epigenomic mechanisms of neural tube defects using multi‐omics methods and data. Annals of the New York Academy of Sciences 1515:1, pages 50-60.
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David M. Engelhardt, Cara A. Martyr & Lee Niswander. (2022) Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure. WIREs Mechanisms of Disease 14:5.
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Nana Li, Lu Li, Zhen Liu, Ying Deng, Meixian Wang, Jinju Zhao, Shengli Zeng, Hong Kang, Yanping Wang, Jun Zhu, Jianxin Zhao & Ping Yu. (2022) The effect of maternal polycyclic aromatic hydrocarbons exposure and methylation levels of congenital heart diseases‐candidate genes on the risk of congenital heart diseases. Prenatal Diagnosis 42:9, pages 1142-1154.
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Aiguo Ren. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1221 1243 .
Kelei Li, Yan Shi, Suqin Zhu, Xianfeng Shao, Huiying Li, Xiaotong Kuang, Shan Li, Xiao-fei Guo & Duo Li. (2021) N-3 polyunsaturated fatty acids effectively protect against neural tube defects in diabetic mice induced by streptozotocin. Food & Function 12:19, pages 9188-9196.
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Heming Wu, Qingyan Huang, Xia Zhang, Zhikang Yu & Zhixiong Zhong. (2021) Analysis of Genomic Copy Number Variation in Miscarriages During Early and Middle Pregnancy. Frontiers in Genetics 12.
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Yun Huang, Shanshan Lin, Chengrong Wang, Xin Pi, Lei Jin, Zhiwen Li, Linlin Wang & Aiguo Ren. (2020) Neural Tube Defects and ZIC4 Hypomethylation in Relation to Polycyclic Aromatic Hydrocarbon Exposure. Frontiers in Cell and Developmental Biology 8.
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Yun Huang, Aiguo Ren, Linlin Wang, Lei Jin, Shanshan Lin, Zhiwen Li & Jasmine A. McDonald. (2019) Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clinical Epigenetics 11:1.
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Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li & Nicholas D. E. Greene. (2019) Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Clinical Epigenetics 11:1.
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Henan Zhang, Yi Guo, Hui Gu, Xiaowei Wei, Wei Ma, Dan Liu, Kun Yu, Wenting Luo, Ling Ma, Yusi Liu, Jia Xue, Jieting Huang, Yanfu Wang, Shanshan Jia, Naixuan Dong, Hongyan Wang & Zhengwei Yuan. (2019) TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis. Clinical Epigenetics 11:1.
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Ramón Cacabelos. 2019. Pharmacoepigenetics. Pharmacoepigenetics 609 709 .
Bei-Hong Liu, Jing Wang, Cong-Min Li, Lin Qi, Yan-Hong Song, Hong Pan, Teng-Yan Li & Bin-Bin Wang. (2018) Novel mutation in SP2 in a Chinese pedigree with Neural tube defects. CNS Neuroscience & Therapeutics 24:10, pages 978-980.
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Tian Tian, Linlin Wang, Yan Shen, Bo Zhang, Richard H Finnell & Aiguo Ren. (2018) Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects . Epigenomics 10:7, pages 891-901.
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