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Expert Opinion on Drug Delivery Volume 14, 2017 - Issue 5
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Review

Recent advances and perspectives in topical oral anesthesia

Michelle Franz-MontanDepartment of Physiological Sciences, Piracicaba Dental School, University of Campinas – UNICAMP, Piracicaba, BrazilCorrespondence[email protected]
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Lígia Nunes de Morais RibeiroDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas – UNICAMP, Campinas, BrazilView further author information
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Maria Cristina VolpatoDepartment of Physiological Sciences, Piracicaba Dental School, University of Campinas – UNICAMP, Piracicaba, BrazilView further author information
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Cintia Maria Saia CeredaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas – UNICAMP, Campinas, Brazil;Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, BrazilView further author information
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Francisco Carlos GroppoDepartment of Physiological Sciences, Piracicaba Dental School, University of Campinas – UNICAMP, Piracicaba, BrazilView further author information
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Giovana Randomille TofoliLaboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, BrazilView further author information
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Daniele Ribeiro de AraújoHuman and Natural Sciences Centre, Federal University of ABC, São Paulo, BrazilView further author information
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Patrizia SantiDepartment of Pharmacy, University of Parma, Parco Area delle Scienze, Parma, ItalyView further author information
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Cristina PadulaDepartment of Pharmacy, University of Parma, Parco Area delle Scienze, Parma, ItalyView further author information
&
Eneida de PaulaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas – UNICAMP, Campinas, BrazilView further author information
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Pages 673-684 | Received 28 May 2016, Accepted 11 Aug 2016, Published online: 01 Sep 2016

Citations (41)

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Luiz E. N. Ferreira, Michelle Franz-Montan, Bruna Benso & Harvinder S. Gill. (2023) Microneedles for oral mucosal delivery – Current trends and perspective on future directions. Expert Opinion on Drug Delivery 20:9, pages 1251-1265.
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Tao Jiang, Shuangshuang Ma, Yangyang Shen, Yuwen Li, Ruirui Pan & Huaixin Xing. (2021) Topical anesthetic and pain relief using penetration enhancer and transcriptional transactivator peptide multi-decorated nanostructured lipid carriers. Drug Delivery 28:1, pages 478-486.
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Daniele Ribeiro de Araújo, Lígia Nunes de Morais Ribeiro & Eneida de Paula. (2019) Lipid-based carriers for the delivery of local anesthetics. Expert Opinion on Drug Delivery 16:7, pages 701-714.
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Lígia Nunes de Morais Ribeiro, Michelle Franz-Montan, Márcia Cristina Breitkreitz, Gustavo Henrique Rodrigues da Silva, Simone Ramos de Castro, Viviane Aparecida Guilherme, Daniele Ribeiro de Araújo & Eneida de Paula. (2018) Nanohybrid hydrogels designed for transbuccal anesthesia. International Journal of Nanomedicine 13, pages 6453-6463.
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Xiangju Zhao, Ying Sun & Zhaoguo Li. (2018) Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system. Drug Design, Development and Therapy 12, pages 4231-4240.
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Articles from other publishers (36)

U. Hemavathi, Saniya Aymen, Akshay Shetty, Roshan Cherian, Shriya Garg & B. S. Jeevan. (2023) Comparative Evaluation of Efficacy of EMLA Versus Ice as Topical Anesthetic in Prior to Needle Prick in Palatine Nerve Blocks—A Randomized Split Mouth Study EMLA Versus Ice as Topical Anesthetic in Dental Nerve Blocks. Journal of Maxillofacial and Oral Surgery 22:2, pages 352-358.
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Ankita Chugh, Surjit Singh, Shruti Khatana, Shubham Gaur, Arun Kumar Patnana, Vinay Chugh & Pravin Kumar. (2021) The Clinical Efficacy of EMLA as a Topical Anesthetic Agent Instead of Palatal Injection During Maxillary Dental Extractions: A Randomized Controlled Trial. Journal of Maxillofacial and Oral Surgery 22:1, pages 172-177.
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Lijia Liu, Dan Wu, Heng Tu, Mengjiao Cao, Mengxin Li, Li Peng & Jing Yang. (2023) Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases. Gels 9:2, pages 146.
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Heba Elmotasem, Salma A. El-Marasy & Amina L. Mohamed. (2023) Benzocaine mesoporous silica nanoparticles/bio polysaccharides-based hydrogels loaded cotton bandage as a platform for topical anesthesia. Results in Chemistry 5, pages 100830.
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Paula de Freitas Rosa Remiro, Mariana Harue Taniguchi Nagahara, Rafael Abboud Azoubel, Michelle Franz-Montan, Marcos Akira d’Ávila & Ângela Maria Moraes. (2022) Polymeric Biomaterials for Topical Drug Delivery in the Oral Cavity: Advances on Devices and Manufacturing Technologies. Pharmaceutics 15:1, pages 12.
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Mingshu Huang, Yisheng Huang, Hongyu Liu, Zhengming Tang, Yuanxin Chen, Zhijie Huang, Shuaimei Xu, Jianzhong Du & Bo Jia. (2022) Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions. Biomaterials Science 10:22, pages 6413-6446.
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Joana Vieira Costa, Jaime Portugal, Cristina Bettencourt Neves & Ana F. Bettencourt. (2021) Should local drug delivery systems be used in dentistry?. Drug Delivery and Translational Research 12:6, pages 1395-1407.
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Jiajia Jiang, Guojiang Yin, Hong Wang & Guosheng Gan. (2022) Observational Study on the Effect of Propofol and Remifentanil Using Modified Topical Anaesthesia Method. International Journal of Pharmacology 18:5, pages 877-882.
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Zequan Zhou, Mengzhen Xing, Suohui Zhang, Guozhong Yang & Yunhua Gao. (2022) Process optimization of Ca2+ cross-linked alginate-based swellable microneedles for enhanced transdermal permeability: More applicable to acidic drugs. International Journal of Pharmaceutics 618, pages 121669.
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Yue Zhang, Ruining Jiang, Lei Lei, Yingming Yang & Tao Hu. (2022) Drug delivery systems for oral disease applications. Journal of Applied Oral Science 30.
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Dorota Kida, Aneta Zakrzewska, Jacek Zborowski, Małgorzata Szulc & Bożena Karolewicz. (2021) Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges. Materials 14:14, pages 3948.
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S.G. Antimisiaris, A. Marazioti, M. Kannavou, E. Natsaridis, F. Gkartziou, G. Kogkos & S. Mourtas. (2021) Overcoming barriers by local drug delivery with liposomes. Advanced Drug Delivery Reviews 174, pages 53-86.
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Jan Schmidt, Martina Kunderova, Nela Pilbauerova & Martin Kapitan. (2021) A Review of Evidence-Based Recommendations for Pericoronitis Management and a Systematic Review of Antibiotic Prescribing for Pericoronitis among Dentists: Inappropriate Pericoronitis Treatment Is a Critical Factor of Antibiotic Overuse in Dentistry. International Journal of Environmental Research and Public Health 18:13, pages 6796.
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Priscila Cordeiro Lima Fernandes, Ludmilla David de Moura, Fernando Freitas de Lima, Gustavo Henrique Rodrigues da Silva, Roosevelt Isaias Carvalho Souza & Eneida de Paula. (2021) Lipid nanocapsules loaded with prilocaine and lidocaine and incorporated in gel for topical application. International Journal of Pharmaceutics 602, pages 120675.
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Renê Oliveira do Couto, Camila Cubayachi, Maíra Peres Ferreira Duarte, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Cristiane Masetto De Gaitani & Osvaldo de Freitas. (2021) Towards the advance of a novel iontophoretic patch for needle-free buccal anesthesia. Materials Science and Engineering: C 122, pages 111778.
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Giovana Maria Fioramonti Calixto, Francesca Damiani Victorelli, Michelle Franz-Montan, Fátima Baltazar & Marlus Chorilli. (2021) Innovative Mucoadhesive Precursor of Liquid Crystalline System Loading Anti-Gellatinolytic Peptide for Topical Treatment of Oral Cancer. Journal of Biomedical Nanotechnology 17:2, pages 253-262.
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Camila Batista da Silva, Maria Cristina Volpato, Bruno Vilela Muniz, Cleiton Pita dos Santos, Luciano Serpe, Luiz Eduardo Nunes Ferreira, Nathalie Ferreira Silva de Melo, Leonardo Fernandes Fraceto, Francisco Carlos Groppo & Michelle Franz-Montan. (2021) Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia. PLOS ONE 16:2, pages e0246760.
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Akel F. Kanaan, Ana P. Piedade, Hermínio C. de Sousa & Ana M.A. Dias. (2021) Semi-interpenetrating chitosan/ionic liquid polymer networks as electro-responsive biomaterials for potential wound dressings and iontophoretic applications. Materials Science and Engineering: C 121, pages 111798.
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Larisse Eduardo ADAMI, Osvaldo de FREITAS, Fellipe Augusto Tocchini de FIGUEIREDO, Maíra Peres FERREIRA, Ana Paula MACEDO, Renê Oliveira do COUTO & Vinicius PEDRAZZI. (2021) Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures. Brazilian Oral Research 35.
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Stephany Di Carla Santos, Nádia Cristina Fávaro-Moreira, Henrique Ballassin Abdalla, Gabriela Gama Xavier Augusto, Yuri Martins Costa, Maria Cristina Volpato, Francisco Carlos Groppo, Harvinder Singh Gill & Michelle Franz-Montan. (2021) A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity. International Journal of Pharmaceutics 592, pages 120050.
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Claudius Illg, Sabrina Krauss, Anabel Kersten, Adrien Daigeler & Andrea Wenger. (2020) Influence of Topical Anesthesia on Superficial Sensitivity: A Double-Blind, Randomized, Placebo-Controlled Study on 48 Healthy Subjects. Dermatologic Surgery 46:12, pages 1593-1598.
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Lígia N. M. Ribeiro, Gustavo H. Rodrigues da Silva, Verônica M. Couto, Simone R. Castro, Márcia C. Breitkreitz, Carolina S. Martinez, Daniela E. Igartúa, Maria J. Prieto & Eneida de Paula. (2020) Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery. Frontiers in Chemistry 8.
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Klinger de Souza Amorim, Michelle Franz-Montan, Francisco Carlos Groppo, Bruno Vilela Muniz, Jaiza Samara Macena de Araújo, José Vânison Ferreira Santana, Anne Caroline Gercina Carvalho Dantas, Eneida de Paula & Liane Maciel de Almeida Souza. (2020) Palatal needle-free anesthesia for upper molars extraction. A randomized clinical trial. Journal of Cranio-Maxillofacial Surgery 48:8, pages 815-819.
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Lígia N. M. Ribeiro, Michelle Franz-Montan, Ana C. S. Alcântara, Márcia C. Breitkreitz, Simone R. Castro, Viviane A. Guilherme, Bruno V. Muniz, Gustavo H. Rodrigues da Silva & Eneida de Paula. (2020) Hybrid nanofilms as topical anesthetics for pain-free procedures in dentistry. Scientific Reports 10:1.
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Hugo Alexandre Silva Favacho, Renê Oliveira do Couto, Maira Peres Ferreira Duarte, Maria Paula Garofo Peixoto, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Cristiane Masetto de Gaitani & Osvaldo de Freitas. (2020) Synergy between surfactants and mucoadhesive polymers enhances the transbuccal permeation of local anesthetics from freeze-dried tablets. Materials Science and Engineering: C 108, pages 110373.
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A Anantharaj, JilineMary Sabu, Sudhir Ramakrishna, RamyaBangalore Jagdeesh, P Praveen & PrathibhaRani Shankarappa. (2020) A comparative evaluation of pain perception following topical application of benzocaine gel, clove-papaya based anesthetic gel and precooling of the injection site before intraoral injections in children. Journal of Indian Society of Pedodontics and Preventive Dentistry 38:2, pages 184.
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Krishnan Padminee, R Hemalatha, P Shankar, D Senthil & Gnanabagyan J Trophimus. (2020) Topical anesthesia for stainless steel crown tooth preparation in primary molars: a pilot study. Journal of Dental Anesthesia and Pain Medicine 20:4, pages 241.
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Xiaoli Liu & Qianqian Zhao. (2019) Long-term anesthetic analgesic effects: Comparison of tetracaine loaded polymeric nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers in vitro and in vivo. Biomedicine & Pharmacotherapy 117, pages 109057.
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Sungjun Hong, Jaesung Park, Ji Eun Kim, Daehwan Park, Seulgi Kim, Jeong Yi Kang, Jin Yong Lee, Woo Jin Hong, Hyanghwa Jeon, Ho Lee & Jin Woong Kim. (2019) Fabrication of cell membrane-adhesive soft polymeric nanovehicles for noninvasive visualization of epidermal-dermal junction-targeted drug delivery. International Journal of Pharmaceutics 565, pages 233-241.
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Ligia N.M. Ribeiro, Ana C.S. Alcantara, Michelle Franz-Montan, Veronica M. Couto, Silvia V.G. Nista & Eneida de Paula. 2019. Biomedical Applications of Nanoparticles. Biomedical Applications of Nanoparticles 341 374 .
Isabella G. Alonso, Lais T. Yamane, Verônica S. de Freitas-Blanco, Luiz F.T. Novaes, Michelle Franz-Montan, Eneida de Paula, Marili V.N. Rodrigues, Rodney A.F. Rodrigues & Julio C. Pastre. (2018) A new approach for the total synthesis of spilanthol and analogue with improved anesthetic activity. Tetrahedron 74:38, pages 5192-5199.
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Apipa Wanasathop & S. Li. (2018) Iontophoretic Drug Delivery in the Oral Cavity. Pharmaceutics 10:3, pages 121.
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Krishnan V Chakravarthy, Frank J Boehm & Paul J Christo. (2018) Nanotechnology: A Promising New Paradigm for the Control of Pain. Pain Medicine 19:2, pages 232-243.
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Yaocun Yue, Dandan Zhao & Qiuwen Yin. (2018) Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery: In vitro and in vivo anesthesia evaluation. Biomedicine & Pharmacotherapy 98, pages 813-820.
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Casey D. Wright, Daniel W. McNeil, Cierra B. Edwards, Richard J. Crout, Katherine Neiswanger, John R. Shaffer & Mary L. Marazita. (2017) Periodontal Status and Quality of Life: Impact of Fear of Pain and Dental Fear. Pain Research and Management 2017, pages 1-9.
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Lígia N. M. Ribeiro, Ana C. S. Alcântara, Gustavo H. Rodrigues da Silva, Michelle Franz-Montan, Silvia V. G. Nista, Simone R. Castro, Verônica M. Couto, Viviane A. Guilherme & Eneida de Paula. (2017) Advances in Hybrid Polymer-Based Materials for Sustained Drug Release. International Journal of Polymer Science 2017, pages 1-16.
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