15,068
Views
53
CrossRef citations to date
0
Altmetric
Editorial

The prodrug approach in the era of drug design

&
Pages 1-5 | Received 28 Sep 2018, Accepted 26 Nov 2018, Published online: 18 Dec 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Hyun Chul Kim, Sangmi Lee, Siyoung Sung, Eunjin Kim, In-Jin Jang & Jae-Yong Chung. (2023) A Comparison of the Pharmacokinetics and Safety of Dapagliflozin Formate, an Ester Prodrug of Dapagliflozin, to Dapagliflozin Propanediol Monohydrate in Healthy Subjects. Drug Design, Development and Therapy 17, pages 1203-1210.
Read now
Anas Najjar & Rafik Karaman. (2019) Successes, failures, and future prospects of prodrugs and their clinical impact. Expert Opinion on Drug Discovery 14:3, pages 199-220.
Read now

Articles from other publishers (51)

Steven E. Caldwell, Chasity P. Janosko & Alexander Deiters. (2024) Development of a light-activated STING agonist. Organic & Biomolecular Chemistry.
Crossref
Rajesh Kumar, Charanjit Kaur, Kawalpreet Kaur, Navneet Khurana & Gurvinder Singh. (2023) Prodrugs: Harnessing chemical modifications for improved therapeutics. Journal of Drug Delivery Science and Technology 90, pages 105103.
Crossref
Asif Husain, Jyoti Monga, Smita Narwal, Gurvirender Singh, Mohammad Rashid, Obaid Afzal, Abdurahhman Alatawi & Norah M Almadani. (2023) Prodrug Rewards in Medicinal Chemistry: An Advance and Challenges Approach for Drug Designing. Chemistry & Biodiversity 20:11.
Crossref
Conrad V. Simoben, Smith B. Babiaka, Aurélien F. A. Moumbock, Cyril T. Namba-Nzanguim, Donatus Bekindaka Eni, José L. Medina-Franco, Stefan Günther, Fidele Ntie-Kang & Wolfgang Sippl. (2023) Challenges in natural product-based drug discovery assisted with in silico -based methods . RSC Advances 13:45, pages 31578-31594.
Crossref
Hamide Ehtesabi, Seyed-Omid Kalji & Mohammad Mahdi Ahadian. (2023) Carbon nanomaterials in prodrug-based therapeutics. Journal of Drug Delivery Science and Technology 88, pages 104930.
Crossref
Arthur Cavalcante Hatae, Cesar Augusto Roque-Borda & Fernando Rogério Pavan. (2023) Strategies for lipid-based nanocomposites with potential activity against Mycobacterium tuberculosis: Microbial resistance challenge and drug delivery trends. OpenNano 13, pages 100171.
Crossref
Bushra K. Jameel, Ayad Mohammed Rasheed Raauf & Wassan Abdul Kareem Abbas. (2023) Synthesis, characterization, molecular docking, in silico ADME study, and in vitro cytotoxicity evaluation of new pyridine derivatives of nabumetone.. Al Mustansiriyah Journal of Pharmaceutical Sciences 23:3, pages 250-262.
Crossref
Sumit Pasricha, Rohit Bhatia, Preeti Patel & Bhupinder Kumar. (2023) Impact of Microfluidic Chip Electrophoresis in Modern Analysis: An Update on Recent Trends. Current Analytical Chemistry 19:5, pages 358-373.
Crossref
Lakshmi Kumari, Yash Choudhari, Preeti Patel, Ghanshyam Das Gupta, Dilpreet Singh, Jessica M. Rosenholm, Kuldeep Kumar Bansal & Balak Das Kurmi. (2023) Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs. Life 13:5, pages 1099.
Crossref
Ragini D. SinghAvadhesh AvadheshGaurav SharmaSagar DholariyaRima B. ShahBela GoyalSubash Chandra Gupta. (2023) Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy. Antioxidants & Redox Signaling 38:10-12, pages 853-876.
Crossref
Chinmayee Choudhury, Vivek Kumar & Rakesh Kumar. (2023) smProdrugs: A repository of small molecule prodrugs. European Journal of Medicinal Chemistry 249, pages 115153.
Crossref
Divya Teli, Pankti Balar, Kishan Patel, Anu Sharma, Vivek Chavda & Lalit Vora. (2023) Molnupiravir: A Versatile Prodrug against SARS-CoV-2 Variants. Metabolites 13:2, pages 309.
Crossref
Sabrina H. Werby, Jasna Brčić, Madeline B. Chosy, Jiuzhi Sun, Jacob T. Rendell, Lewis F. Neville, Paul A. Wender & Lynette Cegelski. (2023) Detection of intact vancomycin–arginine as the active antibacterial conjugate in E. coli by whole-cell solid-state NMR . RSC Medicinal Chemistry.
Crossref
Laura E. McCoubrey, Alessia Favaron, Atheer Awad, Mine Orlu, Simon Gaisford & Abdul W. Basit. (2023) Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics. Journal of Controlled Release 353, pages 1107-1126.
Crossref
Md Aquib, Dickson Pius Wande, Perpetua Takunda Kutoka, Amari Mohamed Khamis, Muhammad Asim Farooq, Fahad Akhtar, Muhammad Sohail & Bo Wang. 2023. Polymeric Nanosystems. Polymeric Nanosystems 241 269 .
Krishna Mohan Poluri, Khushboo Gulati, Deepak Kumar Tripathi & Nupur NagarKrishna Mohan Poluri, Khushboo Gulati, Deepak Kumar Tripathi & Nupur Nagar. 2023. Protein-Protein Interactions. Protein-Protein Interactions 343 428 .
Garima Sharma, Monika Kadian, Priya Joon & Anil Kumar. 2023. Handbook of Oncobiology: From Basic to Clinical Sciences. Handbook of Oncobiology: From Basic to Clinical Sciences 1 12 .
Katherine L. Seley-Radtke, Christianna H. M. Kutz & Joy E. Thames. 2023. Handbook of Chemical Biology of Nucleic Acids. Handbook of Chemical Biology of Nucleic Acids 2037 2106 .
Mira Behnke, Caroline T. Holick, Antje Vollrath, Stephanie Schubert & Ulrich S. Schubert. 2023.
Long Zhang, Yisa Cheng, Ying‐Guo Liu, Xingkuan Chen & Hongmei Liu. (2022) Anticancer Effect of Chlorambucil Enhanced by Chiral Phthalidyl Promoiety. Chemistry & Biodiversity 20:1.
Crossref
João P. Pais, Marta Magalhães, Olha Antoniuk, Ivete Barbosa, Raquel Freire, David Pires, Emília Valente, Bernard Testa, Elsa Anes & Luis Constantino. (2022) Benzoic Acid Derivatives as Prodrugs for the Treatment of Tuberculosis. Pharmaceuticals 15:9, pages 1118.
Crossref
Chaoyi Deng, Jin Liu & Wensheng Zhang. (2022) Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs. Frontiers in Pharmacology 13.
Crossref
William M. Pardridge. (2022) A Historical Review of Brain Drug Delivery. Pharmaceutics 14:6, pages 1283.
Crossref
Marcela Krečmerová, Pavel Majer, Rana Rais & Barbara S. Slusher. (2022) Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects. Frontiers in Chemistry 10.
Crossref
Diego Campos Prieto, Renan Vinícius de Araújo, Sara de Souza Lima, Felipe Zauith Assad, Scott M. Grayson, Ataualpa A.C. Braga, Felipe Rebello Lourenço & Jeanine Giarolla. (2022) Succinylated isoniazid potential prodrug: Design of Experiments (DoE) for synthesis optimization and computational study of the reaction mechanism by DFT calculations. Journal of Molecular Structure 1254, pages 132323.
Crossref
Zhonglei Wang & Liyan Yang. (2021) Broad‐spectrum prodrugs with anti‐SARS‐CoV‐2 activities: Strategies, benefits, and challenges. Journal of Medical Virology 94:4, pages 1373-1390.
Crossref
Sara Pereira, Guanglong Ma, Li Na, Samo Hudoklin, Mateja E. Kreft, Nina Kostevsek & Wafa T. Al-Jamal. (2022) Encapsulation of doxorubicin prodrug in heat-triggered liposomes overcomes off-target activation for advanced prostate cancer therapy. Acta Biomaterialia 140, pages 530-546.
Crossref
Milica Markovic, Suyash Deodhar, Jatin Machhi, Pravin Yeapuri, Maamoon Saleh, Benson J. Edagwa, Rodney Lee Mosley & Howard E. Gendelman. (2022) Prodrug Therapies for Infectious and Neurodegenerative Diseases. Pharmaceutics 14:3, pages 518.
Crossref
Tao Chen, Xunjun Li, Qingyi Mao, Yiyun Wang, Hanyi Li, Chen Wang, Yuyang Shen, Erjia Guo, Qinglie He, Jie Tian, Mansheng Zhu, Jing Wu, Weiqi Liang, Hao Liu, Jiang Yu & Guoxin Li. (2022) An artificial intelligence method to assess the tumor microenvironment with treatment outcomes for gastric cancer patients after gastrectomy. Journal of Translational Medicine 20:1.
Crossref
Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Mathieu Gagné-Boulet, Vincent Ouellette, Jacques Lacroix, Marie-France Côté, René C.-Gaudreault & Sébastien Fortin. (2022) Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation. European Journal of Medicinal Chemistry 229, pages 114003.
Crossref
Katherine L. Seley-Radtke, Christianna H. M. Kutz & Joy E. Thames. 2022. Handbook of Chemical Biology of Nucleic Acids. Handbook of Chemical Biology of Nucleic Acids 1 70 .
Soichiro Ito, Takeshi Hirota, Miyu Yanai, Mai Muto, Eri Watanabe, Yuki Taya & Ichiro Ieiri. (2021) Effects of Genetic Polymorphisms of Cathepsin A on Metabolism of Tenofovir Alafenamide. Genes 12:12, pages 2026.
Crossref
Tahir Khuroo, Sathish Dharani, Eman M. Mohamed, Sujana Immadi, Zhixing Wu, Mansoor A. Khan, Dai Lu, Pramod Nehete & Ziyaur Rahman. (2021) Ultra-long acting prodrug of dolutegravir and delivery system – Physicochemical, pharmacokinetic and formulation characterizations. International Journal of Pharmaceutics 607, pages 120889.
Crossref
Kuan-Ju Chen, Adam J. Plaunt, Franziska G. Leifer, Jeong Yeon Kang & David Cipolla. (2021) Recent advances in prodrug-based nanoparticle therapeutics. European Journal of Pharmaceutics and Biopharmaceutics 165, pages 219-243.
Crossref
Utkarsh Bhutani, Tithi Basu & Saptarshi Majumdar. (2021) Oral Drug Delivery: Conventional to Long Acting New-Age Designs. European Journal of Pharmaceutics and Biopharmaceutics 162, pages 23-42.
Crossref
Steven X. Hu, Kelsey Ernst, Charles P. Benner & Kenneth L. Feenstra. (2021) Stability of Ketoprofen Methylester in Plasma of Different Species. Current Drug Metabolism 22:3, pages 215-223.
Crossref
Sofia Valenti, Maria Barrio, Philippe Negrier, Michela Romanini, Roberto Macovez & Josep-Lluis Tamarit. (2021) Comparative Physical Study of Three Pharmaceutically Active Benzodiazepine Derivatives: Crystalline versus Amorphous State and Crystallization Tendency. Molecular Pharmaceutics 18:4, pages 1819-1832.
Crossref
Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang & Zhen Liu. (2020) Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release. Angewandte Chemie International Edition 60:5, pages 2663-2667.
Crossref
Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang & Zhen Liu. (2020) Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release. Angewandte Chemie 133:5, pages 2695-2699.
Crossref
El Bethel Lalthavel Hmar, Sujata Paul, Nayanmoni Boruah, Priyanka Sarkar, Sudarshana Borah & Hemanta Kumar Sharma. (2021) Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?. Current Pathobiology Reports 9:1, pages 9-32.
Crossref
Rehab Majed Kubba & Aisha Muthana Shanshal. (2021) Theoretical Study to Predict the Ability to Use Different Organic Substituents as Carrier Linkages for Diclofenac. Asian Journal of Chemistry 33:9, pages 2105-2118.
Crossref
Min Li, Jiao Sun, Wenjun Zhang, Yinan Zhao, Shufen Zhang & Shubiao Zhang. (2021) Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy. Carbohydrate Polymers 251, pages 117103.
Crossref
Abdur Rauf Khan, Yuanxiu Liu, Haotong Yang, Xiaoye Yang, Shangui Liu, Jianbo Ji & Guangxi Zhai. (2020) Chondroitin sulfate-based redox-responsive nanoparticles for melanoma-targeted drug delivery. Journal of Drug Delivery Science and Technology 60, pages 102033.
Crossref
Ponsiree Jithavech, Pahweenvaj Ratnatilaka Na Bhuket, Wiwat Supasena, Guanyinsheng Qiu, Shengqing Ye, Jie Wu, Tin Wui Wong & Pornchai Rojsitthisak. (2020) In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species. Frontiers in Pharmacology 11.
Crossref
Burcin Yavuz, Laura Chambre, Kristin Harrington, Jonathan Kluge, Livio Valenti & David L. Kaplan. (2020) Silk Fibroin Microneedle Patches for the Sustained Release of Levonorgestrel. ACS Applied Bio Materials 3:8, pages 5375-5382.
Crossref
Artur Kasprzak, Bartłomiej Dabrowski & Agnieszka Zuchowska. (2020) A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug. RSC Advances 10:39, pages 23440-23445.
Crossref
Milica Markovic, Shimon Ben-Shabat & Arik Dahan. (2020) Computational Simulations to Guide Enzyme-Mediated Prodrug Activation. International Journal of Molecular Sciences 21:10, pages 3621.
Crossref
Abdur Rauf Khan, Xiaoye Yang, Xiyou Du, Haotong Yang, Yuanxiu Liu, Abdul Qayyum Khan & Guangxi Zhai. (2020) Chondroitin sulfate derived theranostic and therapeutic nanocarriers for tumor-targeted drug delivery. Carbohydrate Polymers 233, pages 115837.
Crossref
David J. Newman & Gordon M. Cragg. (2020) Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. Journal of Natural Products 83:3, pages 770-803.
Crossref
Anas Najjar, Abderrahman Najjar & Rafik Karaman. (2020) Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years. Molecules 25:4, pages 884.
Crossref
Bruna Machado Araújo Sanches & Elizabeth Igne Ferreira. 2020. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications 123 154 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.