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Review

Metabolic impact of combined hormonal contraceptives containing estradiol

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Pages 779-787 | Received 19 Mar 2016, Accepted 13 May 2016, Published online: 01 Jun 2016

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Andrea R. Genazzani, Tiziana Fidecicchi, Domenico Arduini, Andrea Giannini & Tommaso Simoncini. (2023) Hormonal and natural contraceptives: a review on efficacy and risks of different methods for an informed choice. Gynecological Endocrinology 39:1.
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Giovanni Grandi, Pierluigi Di Vinci, Alice Sgandurra, Lia Feliciello, Francesca Monari & Fabio Facchinetti. (2022) Contraception During Perimenopause: Practical Guidance. International Journal of Women's Health 14, pages 913-929.
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Giovanni Grandi, Fabio Facchinetti & Johannes Bitzer. (2022) Confirmation of the safety of combined oral contraceptives containing oestradiol on the risk of venous thromboembolism. The European Journal of Contraception & Reproductive Health Care 27:2, pages 83-84.
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Suzanne Reed, Carol Koro, Julia DiBello, Kerstin Becker, Anja Bauerfeind, Christian Franke & Klaas Heinemann. (2021) Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17β-oestradiol (1.5mg) (PRO-E2 study): risk of venous and arterial thromboembolism. The European Journal of Contraception & Reproductive Health Care 26:6, pages 439-446.
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Maria Chiara Del Savio, Riccardo De Fata, Fabio Facchinetti & Giovanni Grandi. (2020) Drospirenone 4 mg-only pill (DOP) in 24+4 regimen: a new option for oral contraception. Expert Review of Clinical Pharmacology 13:7, pages 685-694.
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Giovanni Grandi, Maria Chiara Del Savio, Agnaldo Lopes da Silva-Filho & Fabio Facchinetti. (2020) Estetrol (E4): the new estrogenic component of combined oral contraceptives. Expert Review of Clinical Pharmacology 13:4, pages 327-330.
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Jeffrey T. Jensen, Johannes Bitzer, Rossella E. Nappi, Christiane Ahlers, Ralf Bannemerschult & Susanne Parke. (2020) Pooled analysis of bleeding profile, efficacy and safety of oral oestradiol valerate/dienogest in women aged 25 and under. The European Journal of Contraception & Reproductive Health Care 25:2, pages 98-105.
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Giovanni Grandi, Fabio Barra, Simone Ferrero & Fabio Facchinetti. (2019) Estradiol in non-oral hormonal contraception: a “long and winding road”. Expert Review of Endocrinology & Metabolism 14:3, pages 153-155.
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Giovanni Grandi, Fabio Facchinetti & Johannes Bitzer. (2017) Estradiol in hormonal contraception: real evolution or just same old wine in a new bottle?. The European Journal of Contraception & Reproductive Health Care 22:4, pages 245-246.
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Angelo Cagnacci. (2017) Hormonal contraception: venous and arterial disease. The European Journal of Contraception & Reproductive Health Care 22:3, pages 191-199.
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Carlo Bastianelli, Manuela Farris, Elena Rosato, Ivo Brosens & Giuseppe Benagiano. (2017) Pharmacodynamics of combined estrogen-progestin oral contraceptives: 1. Effects on metabolism. Expert Review of Clinical Pharmacology 10:3, pages 315-326.
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Ömer Özcan, Wendy P.J. den Elzen, Jacquelien J. Hillebrand, Martin den Heijer, Laura L. van Loendersloot, Johan Fischer, Henrike Hamer, Robert de Jonge & Annemieke C. Heijboer. (2024) The effect of hormonal contraceptive therapy on clinical laboratory parameters: a literature review. Clinical Chemistry and Laboratory Medicine (CCLM) 62:1, pages 18-40.
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Giuseppe Seghieri, Elisa Gualdani, Flavia Franconi, Ilaria Campesi, Graziano Di Cianni & Paolo Francesconi. (2023) Pregestational exposure to hormonal combined contraceptives and risk of gestational diabetes: an observational retrospective population study. Acta Diabetologica.
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Giovanni Grandi, Maria C. Del Savio, Alice Tassi & Fabio Facchinetti. (2023) Postpartum contraception: A matter of guidelines. International Journal of Gynecology & Obstetrics.
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Anna Helena Mazurek, Łukasz Szeleszczuk, Kostas Bethanis, Elias Christoforides, Marta Katarzyna Dudek, Monika Zielińska-Pisklak & Dariusz Maciej Pisklak. (2023) 17-β-Estradiol—β-Cyclodextrin Complex as Solid: Synthesis, Structural and Physicochemical Characterization. Molecules 28:9, pages 3747.
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Veronika I. Komedina, Svetlana V. Yureneva & Sergey Yu. Kuznetsov. (2023) Effect of combined oral contraceptives with estrogen identical to natural estrogen on the metabolic profile and body composition in females during the menopausal transition. Gynecology 24:6, pages 487-493.
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M H Kangasniemi, R K Arffman, S Joenväärä, A Haverinen, K Luiro, T Tohmola, R Renkonen, O Heikinheimo, J S Tapanainen & T T Piltonen. (2023) Ethinylestradiol in combined hormonal contraceptive has a broader effect on serum proteome compared with estradiol valerate: a randomized controlled trial. Human Reproduction 38:1, pages 89-102.
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L.I. Maltseva & Yu.V. Garifullova. (2023) Long-term contraception with combined hormonal drugs until menopause. Benefits and risks. Problemy reproduktsii 29:5, pages 102.
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Pedro-Antonio Regidor, Anna Mueller & Manuela Mayr. (2023) Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen. Women's Health 19, pages 174550572211473.
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Ilaria Campesi & Flavia Franconi. 2023. Principles of Gender-Specific Medicine. Principles of Gender-Specific Medicine 869 886 .
Camila G. Neves, Adriana L. Montiel, Fausto E. B. Junior, Guilherme C. Paveglio & Willyam R. P. Barros. (2022) Application of a Screen-Printed Carbon Electrode Modified with Printex 6L and Deep Eutectic Solvent for Detection and Quantification of 17β-estradiol. Journal of The Electrochemical Society 169:5, pages 057501.
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Decio Armanini, Marco Boscaro, Luciana Bordin & Chiara Sabbadin. (2022) Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism. International Journal of Molecular Sciences 23:8, pages 4110.
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Costantino DI CARLO, Massimo ABBONDANZA, Antonella AGNELLO, Giovanni CAVALLI, Lorenza DRIUL, Massimo PETRIGLIA, Andrea TINELLI, Alessandra TIRELLI, Anna TUSEI & Giovanni GRANDI. (2021) Current and future hormonal contraception in Italy: results from an Italian consensus expert meeting. Minerva Obstetrics and Gynecology 73:5.
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Gerda Venter, Carien L. van der Berg, Francois H. van der Westhuizen & Elardus Erasmus. (2021) Health Status Is Affected, and Phase I/II Biotransformation Activity Altered in Young Women Using Oral Contraceptives Containing Drospirenone/Ethinyl Estradiol. International Journal of Environmental Research and Public Health 18:20, pages 10607.
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Jovana Mihajlovic, Michael Leutner, Bela Hausmann, Gudrun Kohl, Jasmin Schwarz, Hannah Röver, Nina Stimakovits, Peter Wolf, Katharina Maruszczak, Magdalena Bastian, Alexandra Kautzky‐Willer & David Berry. (2021) Combined hormonal contraceptives are associated with minor changes in composition and diversity in gut microbiota of healthy women. Environmental Microbiology 23:6, pages 3037-3047.
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Christine Klipping, Ingrid Duijkers, Marie Mawet, Catherine Maillard, Adriana Bastidas, Maud Jost & Jean-Michel Foidart. (2021) Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone. Contraception 103:4, pages 213-221.
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R.I. Gabidullina, E.I. Galimyanova & R.R. Salakhova. (2021) Effects of combined oral contraceptives on female sexuality: continuing the conversation. Problemy reproduktsii 27:5, pages 54.
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Andrea Cignarella, Roberto Mioni, Chiara Sabbadin, Francesca Dassie, Matteo Parolin, Roberto Vettor, Mattia Barbot & Carla Scaroni. (2020) Pharmacological Approaches to Controlling Cardiometabolic Risk in Women with PCOS. International Journal of Molecular Sciences 21:24, pages 9554.
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Jonathan Douxfils, Laure Morimont & Céline Bouvy. (2020) Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk. Seminars in Thrombosis and Hemostasis 46:08, pages 872-886.
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Marika H Kangasniemi, Annina Haverinen, Kaisu Luiro, J Kalervo Hiltunen, Elina K Komsi, Riikka K Arffman, Oskari Heikinheimo, Juha S Tapanainen & Terhi T Piltonen. (2020) Estradiol Valerate in COC Has More Favorable Inflammatory Profile Than Synthetic Ethinyl Estradiol: A Randomized Trial. The Journal of Clinical Endocrinology & Metabolism 105:7, pages e2483-e2490.
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Łukasz Szeleszczuk, Dariusz Maciej Pisklak, Monika Zielińska-Pisklak & Ewa Jurczak. (2019) A new polymorph of 17-β-estradiol and the application of different analytical techniques (ssNMR, PXRD, DSC, and FTIR) for its study. Journal of Molecular Structure 1183, pages 274-280.
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G. В. Dikke. (2019) Therapeutic tactics in abnormal uterine bleeding without anatomical substrate. Medical Council:21, pages 168-172.
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Łukasz Szeleszczuk, Ewa Jurczak, Monika Zielińska-Pisklak, Jakub Harwacki & Dariusz Maciej Pisklak. (2018) Comparison of the analytical methods (solid state NMR, FT-IR, PXRD) in the analysis of the solid drug forms with low concentration of an active ingredient – 17-β-estradiol case. Journal of Pharmaceutical and Biomedical Analysis 149, pages 160-165.
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G. B. Dikke. (2018) Protective activity and safety of multiphase combined oral contraceptive based on natural estrogens in women of advanced age. Problemy reproduktsii 24:3, pages 27.
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