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Expert Opinion on Drug Metabolism & Toxicology Volume 15, 2019 - Issue 8
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Review

The potential protein-mediated hepatic uptake: discussion on the molecular interactions between albumin and the hepatocyte cell surface and their implications for the in vitro-to-in vivo extrapolations of hepatic clearance of drugs

Michel BteichDepartment of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, CanadaView further author information
,
Patrick PoulinDepartment of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, Canada;Consultant Patrick Poulin Inc., Québec city, CanadaView further author information
&
Sami HaddadDepartment of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8906-9693View further author information
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Pages 633-658 | Received 10 May 2019, Accepted 03 Jul 2019, Published online: 18 Jul 2019

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Julia Annette Schulz, David M. Stresser & John Cory Kalvass. (2023) Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review. Drug Metabolism Reviews 55:3, pages 205-238.
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Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M. Lauschke, Jessica H. Hartman & Laura E. Russell. (2021) Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metabolism Reviews 53:2, pages 207-233.
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Ravindra V. Alluri, Rui Li & Manthena V. S. Varma. (2020) Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?. Expert Opinion on Drug Metabolism & Toxicology 16:5, pages 387-401.
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Anna Zerdoug, Marc Le Vée, Shotaro Uehara, Béatrice Lopez, Christophe Chesné, Hiroshi Suemizu & Olivier Fardel. (2022) Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives. European Journal of Drug Metabolism and Pharmacokinetics 47:5, pages 621-637.
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Seiji Miyauchi, Soo-Jin Kim, Wooin Lee & Yuichi Sugiyama. (2022) Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo. Pharmacology & Therapeutics 229, pages 107938.
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Patrick Poulin & Sami Haddad. (2021) A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions. Journal of Pharmaceutical Sciences 110:7, pages 2841-2858.
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Sophia Krause & Kai-Uwe Goss. (2021) Relevance of desorption kinetics and permeability for in vitro-based predictions of hepatic clearance in fish. Aquatic Toxicology 235, pages 105825.
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Sophia Krause & Kai-Uwe Goss. (2021) Could chemical exposure and bioconcentration in fish be affected by slow binding kinetics in blood?. Environmental Science: Processes & Impacts 23:5, pages 714-722.
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Michel Bteich, Patrick Poulin & Sami Haddad. (2021) Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid Glycoprotein. Journal of Pharmaceutical Sciences 110:3, pages 1385-1391.
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Jung-Hwan Kwon, Hyun-Jeoung Lee & Beate I. Escher. (2020) Bioavailability of hydrophobic organic chemicals on an in vitro metabolic transformation using rat liver S9 fraction. Toxicology in Vitro 66, pages 104835.
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Fabian C. Fischer, Cedric Abele, Luise Henneberger, Nils Klüver, Maria König, Marie Mühlenbrink, Rita Schlichting & Beate I. Escher. (2020) Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro – In Vivo Extrapolation . Chemical Research in Toxicology 33:7, pages 1770-1779.
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Yiting Yang & Xiaodong Liu. (2020) Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance. Pharmaceutics 12:4, pages 348.
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Christine M. Bowman, Eugene Chen, Liuxi Chen, Yi-Chen Chen, Xiaorong Liang, Matthew Wright, Yuan Chen & Jialin Mao. (2020) Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma. Drug Metabolism and Disposition 48:1, pages 18-24.
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Hong-Jaan Wang & Leslie Z. Benet. (2019) Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation. Drug Metabolism and Disposition 47:12, pages 1397-1402.
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Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor, Raymond Evers, Paresh P. Chothe, Osatohanmwen J. Enogieru, Xiaomin Liang, Yurong Lai & Jashvant D. Unadkat. (2022) The Next Frontier in ADME Science: Predicting Transporter-Based Drug Disposition, Tissue Concentrations and Drug-Drug Interactions in Humans. SSRN Electronic Journal.
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