Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 16, 2020 - Issue 3
Submit an article Journal homepage
597
Views
40
CrossRef citations to date
0
Altmetric
Review

Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

Fabio FacchinettiDepartment of Obstetrics and Gynecology and Pediatrics, University of Modena and Reggio Emilia, Modena, ItalyView further author information
,
Marialuisa AppetecchiaOncological Endocrinology Unit, Regina Elena National Cancer Institute - IRCCS, Rome, ItalyView further author information
,
Cesare AragonaSystems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyView further author information
,
Arturo BevilacquaDepartment of Dynamic and Clinical Psychology, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-8889-2634View further author information
ORCID Icon,
Maria Salome Bezerra EspinolaSystems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyView further author information
,
Mariano BizzarriSystems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-0408-4136View further author information
ORCID Icon,
Rosario D’AnnaUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, ItalyView further author information
,
Didier DewaillyFaculty of Medicine, University of Lille, Lille, France;INSERM, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, FranceView further author information
,
Evanthia Diamanti-KandarakisDepartment of Endocrinology & Diabetes, HYGEIA Hospital, Marousi, Athens, GreeceView further author information
,
Imelda Hernández MarínHuman Reproduction Department, Hospital Juárez de México, México CityMexico;Facultad de Medicina, Universidad Nacional Autónoma De México (UNAM), México City, MéxicoView further author information
,
Zdravko A. KamenovDepartment of Internal Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Eleni KandarakiDepartment of Endocrinology & Diabetes, HYGEIA Hospital, Marousi, Athens, GreeceView further author information
,
Antonio Simone LaganàDepartment of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese, ItalyORCID Iconhttps://orcid.org/0000-0003-1543-2802View further author information
ORCID Icon,
Giovanni MonastraSystems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-2012-1435View further author information
ORCID Icon,
Mario Montanino OlivaDepartment of Obstetrics and Gynecology, “Santo Spirito” Hospital, Rome, ItalyView further author information
,
John E. NestlerDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
,
Francesco OrioDepartment of Endocrinology, “Parthenope” University of Naples, ItalyView further author information
,
Ali Cenk OzayFaculty of Medicine, Department of Obstetrics and Gynecology, Near East University, NicosiaCyprus;Near East University, Research Center of Experimental Health Sciences, Nicosia, CyprusView further author information
,
Olga PapalouDepartment of Endocrinology & Diabetes, HYGEIA Hospital, Marousi, Athens, GreeceView further author information
,
Lali PkhaladzeDepartment of Gynecological Endocrinology, Ioseb Zhordania Institute of Reproductology, Tbilisi, GeorgiaView further author information
,
Giusy PorcaroWomen’s Health Center, Orvieto, ItalyView further author information
,
Nikos Prapas3rd Department of OB-GYNAE, Aristotle University of Thessaloniki, ThessalonikiGreece;IVF Laboratory, IAKENTRO Fertility Centre, Thessaloniki, GreeceView further author information
,
Christophe O. SoulageDepartment of BioSciences, University of Lyon, Villeurbanne, FranceView further author information
,
Annarita StringaroNational Center for Drug Research and Evaluation - Italian National Institute of Health, Rome, ItalyView further author information
,
Artur WdowiakDiagnostic Techniques Unit, Medical University of Lublin, PolandView further author information
&
Vittorio UnferDepartment of Experimental Medicine, Sapienza University of Rome, Rome, ItalyCorrespondence[email protected]
View further author information
 show all
Pages 255-274 | Received 20 Nov 2019, Accepted 28 Feb 2020, Published online: 19 Mar 2020

Citations (40)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Mariano Bizzarri, Patrizia Logoteta, Giovanni Monastra & Antonio Simone Laganà. (2022) An innovative approach to polycystic ovary syndrome. Journal of Obstetrics and Gynaecology 42:4, pages 546-556.
Read now
Antonio Simone Laganà, Gianpiero Forte, Mariano Bizzarri, Zdravko A. Kamenov, Bianca Bianco, Cihan Kaya, Georgios Gitas, Ibrahim Alkatout, Milan Terzic & Vittorio Unfer. (2022) Inositols in the ovaries: activities and potential therapeutic applications. Expert Opinion on Drug Metabolism & Toxicology 18:2, pages 123-133.
Read now
Marta Santoro, Saveria Aquila & Giampiero Russo. (2021) Sperm performance in oligoasthenoteratozoospermic patients is induced by a nutraceuticals mix, containing mainly myo-inositol. Systems Biology in Reproductive Medicine 67:1, pages 50-63.
Read now
Fabio Facchinetti, Pietro Cavalli, Andrew J. Copp, Rosario D’Anna, Eleni Kandaraki, Nicholas D. E. Greene & Vittorio Unfer. (2020) An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). Expert Opinion on Drug Metabolism & Toxicology 16:12, pages 1187-1198.
Read now
Manuel Luque-Ramírez, Andrés E. Ortiz-Flores, Lia Nattero-Chávez & Héctor F. Escobar-Morreale. (2020) A safety evaluation of current medications for adult women with the polycystic ovarian syndrome not pursuing pregnancy. Expert Opinion on Drug Safety 19:12, pages 1559-1576.
Read now
Antonio Simone Laganà, Simone Garzon & Vittorio Unfer. (2020) New clinical targets of d-chiro-inositol: rationale and potential applications. Expert Opinion on Drug Metabolism & Toxicology 16:8, pages 703-710.
Read now
Luigi Della Corte, Virginia Foreste, Fabio Barra, Claudio Gustavino, Franco Alessandri, Maria Grazia Centurioni, Simone Ferrero, Giuseppe Bifulco & Pierluigi Giampaolino. (2020) Current and experimental drug therapy for the treatment of polycystic ovarian syndrome. Expert Opinion on Investigational Drugs 29:8, pages 819-830.
Read now

Articles from other publishers (33)

Giovanni Monastra, Riccardo Gambioli, Vittorio Unfer, Gianpiero Forte, Elsa Maymo-Masip & Raffaella Comitato. (2023) D-Chiro-Inositol and Myo-Inositol Induce WAT/BAT Trans-Differentiation in Two Different Human Adipocyte Models (SGBS and LiSa-2). International Journal of Molecular Sciences 24:8, pages 7421.
Crossref
Valeria Fedeli, Angela Catizone, Alessandro Querqui, Vittorio Unfer & Mariano Bizzarri. (2023) The Role of Inositols in the Hyperandrogenic Phenotypes of PCOS: A Re-Reading of Larner’s Results. International Journal of Molecular Sciences 24:7, pages 6296.
Crossref
Immacolata Blasi, Jessica Daolio, Valeria Pugni, Giuseppina Comitini, Marcello Morciano, Giorgio Grassi, Tullia Todros, Giancarlo Gargano & Lorenzo Aguzzoli. (2023) Correlations between parameters of glycaemic variability and foetal growth, neonatal hypoglycaemia and hyperbilirubinemia in women with gestational diabetes. PLOS ONE 18:3, pages e0282895.
Crossref
Zdravko Kamenov & Mario Montanino Oliva. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 65 72 .
Giovanni Monastra, Simona Dinicola & Vittorio Unfer. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 9 29 .
Evanthia Diamanti-Kandarakis, Olga Papalou & Christophe O. Soulage. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 31 51 .
Lali Pkhaladze, Vittorio Unfer & Didier Dewailly. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 151 165 .
Evgenia V. Shikh, Ludmila Yu. Grebenshikova, Olga V. Zhukova & Alina A. Bagdasaryan. (2022) Myo-inositol in the treatment of male factor infertility. Gynecology 24:4, pages 319-326.
Crossref
Jingshu Wei, Jie Yan & Huixia Yang. (2022) Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 14:14, pages 2831.
Crossref
Ebrar Nur Şahin, Abdullah Karanfil, Melek Çol Ayvaz, Ertan Şahin & Latif Kelebekli. (2022) Structural analysis of halogenated bicyclo[4.2.0] inositols, biological activities and molecular docking studies. Journal of Molecular Structure 1248, pages 131357.
Crossref
Vittorio Unfer, Giovanni Monastra, Marco Tilotta, Gianpiero Forte & Simona Dinicola. 2022. Polycystic Ovary Syndrome. Polycystic Ovary Syndrome 167 186 .
Joanna Płonka, Joanna Szablińska-Piernik, Bogusław Buszewski, Irena Baranowska & Lesław B. Lahuta. (2021) Analyses of Antioxidative Properties of Selected Cyclitols and Their Mixtures with Flavanones and Glutathione. Molecules 27:1, pages 158.
Crossref
Wei Gong, Aikmu Bilixzi, Xinmei Wang, Yanli Lu, Li Wan & Lu Han. (2021) The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?. BMC Women's Health 21:1.
Crossref
Giovanni Monastra, Mónica Vazquez-Levin, Maria Salome Bezerra Espinola, Gabriele Bilotta, Antonio Simone Laganà & Vittorio Unfer. (2021) D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study. Basic and Clinical Andrology 31:1.
Crossref
Rosario D’Anna, Francesco Corrado, Saverio Loddo, Giuseppe Gullo, Loretta Giunta & Antonino Di Benedetto. (2021) Myoinositol plus α-lactalbumin supplementation, insulin resistance and birth outcomes in women with gestational diabetes mellitus: a randomized, controlled study. Scientific Reports 11:1.
Crossref
Simona Dinicola, Vittorio Unfer, Fabio Facchinetti, Christophe O. Soulage, Nicholas D. Greene, Mariano Bizzarri, Antonio Simone Laganà, Shiao-Yng Chan, Arturo Bevilacqua, Lali Pkhaladze, Salvatore Benvenga, Annarita Stringaro, Daniele Barbaro, Marialuisa Appetecchia, Cesare Aragona, Maria Salomè Bezerra Espinola, Tonino Cantelmi, Pietro Cavalli, Tony T. Chiu, Andrew J. Copp, Rosario D’Anna, Didier Dewailly, Cherubino Di Lorenzo, Evanthia Diamanti-Kandarakis, Imelda Hernández Marín, Moshe Hod, Zdravko Kamenov, Eleni Kandaraki, Giovanni Monastra, Mario Montanino Oliva, John E. Nestler, Maurizio Nordio, Ali C. Ozay, Olga Papalou, Giuseppina Porcaro, Nikos Prapas, Scott Roseff, Monica Vazquez-Levin, Ivana Vucenik & Artur Wdowiak. (2021) Inositols: From Established Knowledge to Novel Approaches. International Journal of Molecular Sciences 22:19, pages 10575.
Crossref
Arturo Bevilacqua, Jessica Dragotto, Micaela Lucarelli, Giovanna Di Emidio, Giovanni Monastra & Carla Tatone. (2021) High Doses of D-Chiro-Inositol Alone Induce a PCO-Like Syndrome and Other Alterations in Mouse Ovaries. International Journal of Molecular Sciences 22:11, pages 5691.
Crossref
Yue Ma, Linna Ma, Yurong Cao & Jun Zhai. (2021) Construction of a ceRNA-based lncRNA-mRNA network to identify functional lncRNAs in polycystic ovarian syndrome. Aging 13:6, pages 8481-8496.
Crossref
Paula Sofía Vanhauwaert. (2021) Síndrome de ovario poliquístico e infertilidad. Revista Médica Clínica Las Condes 32:2, pages 166-172.
Crossref
Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz, Razieh Bidhendi Yarandi & Samira Behboudi-Gandevani. (2021) The Impact of Diagnostic Criteria for Gestational Diabetes Mellitus on Adverse Maternal Outcomes: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine 10:4, pages 666.
Crossref
Kadir Aksu, Hulya Akincioglu, Ilhami Gulcin & Latif Kelebekli. (2020) Concise syntheses and some biological activities of dl ‐2,5‐di‐ O ‐methyl‐ chiro ‐inositol, dl ‐1,4‐di‐ O ‐methyl‐ scyllo ‐inositol, and dl ‐1,6‐dibromo‐1,6‐dideoxy‐2,5‐di‐ O ‐methyl‐ chiro ‐inositol . Archiv der Pharmazie 354:2, pages 2000254.
Crossref
MeryemKuru Pekcan, ASeval Ozgu-Erdinc, Nafiye Yilmaz, Aytekin Tokmak & Yaprak Engin-Ustun. (2021) Inflammatory markers in peripheral blood cells cannot predict intrauterine insemination outcome: A retrospective cohort study. Journal of Human Reproductive Sciences 14:1, pages 11.
Crossref
Krystallenia I Alexandraki, Eleni A Kandaraki, Kalliopi-Anna Poulia, Christina Piperi, Eirini Papadimitriou & Theodoros G Papaioannou. (2021) Assessment of Early Markers of Cardiovascular Risk in Polycystic Ovary Syndrome. European Endocrinology 1:1, pages 37.
Crossref
Małgorzata Szczuko, Justyna Kikut, Natalia Komorniak, Jacek Bilicki, Zbigniew Celewicz & Maciej Ziętek. (2020) The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process. International Journal of Molecular Sciences 21:24, pages 9628.
Crossref
Zdravko Kamenov & Antoaneta Gateva. (2020) Inositols in PCOS. Molecules 25:23, pages 5566.
Crossref
Antonio Simone Laganà, Vittorio Unfer, Simone Garzon & Mariano Bizzarri. (2020) Role of inositol to improve surfactant functions and reduce IL-6 levels: A potential adjuvant strategy for SARS-CoV-2 pneumonia?. Medical Hypotheses 144, pages 110262.
Crossref
Vittorio Unfer, Simona Dinicola, Antonio Simone Laganà & Mariano Bizzarri. (2020) Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS. International Journal of Molecular Sciences 21:19, pages 7157.
Crossref
Agata Wawrzkiewicz-Jałowiecka, Karolina Kowalczyk, Paulina Trybek, Tomasz Jarosz, Patrycja Radosz, Marcin Setlak & Paweł Madej. (2020) In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond. International Journal of Molecular Sciences 21:19, pages 7054.
Crossref
Justyna Kikut, Natalia Komorniak, Maciej Ziętek, Joanna Palma & Małgorzata Szczuko. (2020) Inflammation with the participation of arachidonic (AA) and linoleic acid (LA) derivatives (HETEs and HODEs) is necessary in the course of a normal reproductive cycle and pregnancy. Journal of Reproductive Immunology 141, pages 103177.
Crossref
Shiqi Yi, Jiawei Xu, Hao Shi, Wenbo Li, Qian Li & Ying-pu Sun. (2020) Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis. Bioscience Reports 40:6.
Crossref
Arianna Pani, Ilaria Gironi, Giacoma Di Vieste, Elena Mion, Federico Bertuzzi & Basilio Pintaudi. (2020) From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management. International Journal of Endocrinology 2020, pages 1-10.
Crossref
Yuanyuan Li, Jia Guo, Shoulong Deng, Zili Gao, Yixun Liu & Qi Gu. (2020) Fibrin Facilitates Mesenchymal Stem Cells to Ameliorate Rats with Polycystic Ovary Syndrome. Applied Sciences 10:10, pages 3598.
Crossref
Aigul Safi, Mekan Orazov & Svetlana Kalinchenko. (2020) The role of cholecalciferol deficiency in the pathogenesis of polycystic ovary syndrome. Women's Health 16, pages 174550652096960.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.