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Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2021 - Issue 3
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Review

Interactions of janus kinase inhibitors with drug transporters and consequences for pharmacokinetics and toxicity

Karima Alima Univ Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, France
,
Arnaud Bruyèrea Univ Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, France
,
Alain Lescoata Univ Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, France
,
Elodie Jouana Univ Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, France
,
Valérie Lecureura Univ Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, France
,
Marc Le Véea Univ Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, France
&
Olivier Fardelb Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut De Recherche En Santé, Environnement Et Travail) - UMR_S 1085, Rennes, FranceCorrespondence[email protected]
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Pages 259-271 | Received 13 Aug 2020, Accepted 07 Dec 2020, Published online: 11 Jan 2021

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Abdelmoujoud Faris, Ibrahim M. Ibrahim, Hanine Hadni & Menana Elhallaoui. (2023) High-throughput virtual screening of phenylpyrimidine derivatives as selective JAK3 antagonists using computational methods. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-26.
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Arnaud Bruyère, Marc Le Vée, Elodie Jouan, Stephanie Molez, Anne T. Nies & Olivier Fardel. (2021) Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters. Xenobiotica 51:4, pages 467-478.
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Articles from other publishers (13)

Anniina Virtanen, Maaria Palmroth, Sanna Liukkonen, Antti Kurttila, Teemu Haikarainen, Pia Isomäki & Olli Silvennoinen. (2023) Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling . Arthritis & Rheumatology 75:11, pages 2054-2061.
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Isabelle Melki & Marie-Louise Frémond. (2023) JAK Inhibition in Juvenile Idiopathic Arthritis (JIA): Better Understanding of a Promising Therapy for Refractory Cases. Journal of Clinical Medicine 12:14, pages 4695.
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T. Y. J. Appeldoorn, T. H. Oude Munnink, L. M. Morsink, M. N. Lub-de Hooge & D. J. Touw. (2023) Pharmacokinetics and Pharmacodynamics of Ruxolitinib: A Review. Clinical Pharmacokinetics 62:4, pages 559-571.
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Fangrui Xiu, Magdalena Rausch, Zhibo Gai, Shanshan Su, Shijun Wang & Michele Visentin. (2023) The Role of Organic Cation Transporters in the Pharmacokinetics, Pharmacodynamics and Drug–Drug Interactions of Tyrosine Kinase Inhibitors. International Journal of Molecular Sciences 24:3, pages 2101.
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David Malnoë, Olivier Fardel & Pascal Le Corre. (2022) Involvement of Transporters in Intestinal Drug–Drug Interactions of Oral Targeted Anticancer Drugs Assessed by Changes in Drug Absorption Time. Pharmaceutics 14:11, pages 2493.
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Adina EichnerJohannes Wohlrab. (2022) Pharmakologie der Januskinase‐Inhibitoren – Teil 1: Pharmakokinetik. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 20:11, pages 1485-1500.
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Adina Eichner & Johannes Wohlrab. (2022) Pharmacology of inhibitors of Janus kinases – Part 1: Pharmacokinetics. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 20:11, pages 1485-1499.
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Yasamin Kalantari, Sara Sadeghi, Delaram Asadi & Azadeh Goodarzi. (2022) A literature review on Janus kinase (JAK) inhibitors for the treatment of immunobullous disorders. International Immunopharmacology 110, pages 108923.
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S. Djabarouti, P. Mora, M. Lahouati, M. Gigan, N. d’Houdain, B. Sourisseau, J. Chambord & F. Xuereb. (2022) Intérêt des dosages pharmacologiques d’immunosuppresseurs et immunomodulateurs dans la prise en charge des maladies autoimmunes. La Revue de Médecine Interne 43:7, pages 412-418.
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Jérôme Hadjadj, Marie-Louise Frémond & Bénédicte Neven. (2021) Emerging Place of JAK Inhibitors in the Treatment of Inborn Errors of Immunity. Frontiers in Immunology 12.
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Alain Lescoat, David Roofeh, Masataka Kuwana, Robert Lafyatis, Yannick Allanore & Dinesh Khanna. (2021) Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies. Clinical Reviews in Allergy & Immunology 64:3, pages 239-261.
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Milo Gatti, Eleonora Turrini, Emanuel Raschi, Piero Sestili & Carmela Fimognari. (2021) Janus Kinase Inhibitors and Coronavirus Disease (COVID)-19: Rationale, Clinical Evidence and Safety Issues. Pharmaceuticals 14:8, pages 738.
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Igor A. Schepetkin, Mark B. Plotnikov, Andrei I. Khlebnikov, Tatiana M. Plotnikova & Mark T. Quinn. (2021) Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential. Biomolecules 11:6, pages 777.
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