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Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2021 - Issue 8: Alternatives to Animal Models in Toxicology
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Review

Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance

Xiaomin LiangDrug Metabolism, Gilead Sciences Inc., Foster City, CA, USAView further author information
&
Yurong LaiDrug Metabolism, Gilead Sciences Inc., Foster City, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9505-333XView further author information
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Pages 869-886 | Received 04 Sep 2020, Accepted 30 Mar 2021, Published online: 15 Jun 2021

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Pin Jiang, Tao Chen, Lin-Feng Chu, Ren-Peng Xu, Jin-Ting Gao, Li Wang, Qiang Liu, Lily Tang, Hong Wan, Ming Li & Hong-Can Ren. (2023) Enhancing drug-drug Interaction Prediction by Integrating Physiologically-Based Pharmacokinetic Model with Fraction Metabolized by CYP3A4. Expert Opinion on Drug Metabolism & Toxicology 19:10, pages 721-731.
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Elisa Giovannetti & Godefridus Peters. (2021) Beyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems. Expert Opinion on Drug Metabolism & Toxicology 17:8, pages 867-868.
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Articles from other publishers (3)

Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury & Paresh P. Chothe. (2022) Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model. Drug Metabolism and Disposition 50:7, pages 980-988.
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Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang & Xinxin Ding. (2022) Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development. Acta Pharmaceutica Sinica B 12:6, pages 2751-2777.
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Hong Shen, Zheng Yang & A. David Rodrigues. (2022) Cynomolgus Monkey as an Emerging Animal Model to Study Drug Transporters: In Vitro, In Vivo, In Vitro-to-In Vivo Translation. Drug Metabolism and Disposition 50:3, pages 299-319.
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