Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2021 - Issue 8: Alternatives to Animal Models in Toxicology
Submit an article Journal homepage
970
Views
24
CrossRef citations to date
0
Altmetric
Review

High-throughput PBTK models for in vitro to in vivo extrapolation

Miyuki Breena Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USAView further author information
,
Caroline L Ringa Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USAView further author information
,
Anna Kreutzb Oak Ridge Institute for Science and Education (ORISE) fellow at the Center for Computational Toxicology and Exposure, Office of Research and Development, Research Triangle Park, NC, USAView further author information
,
Michael-Rock Goldsmitha Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USAView further author information
&
John F Wambaugha Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USACorrespondence[email protected]
View further author information
Pages 903-921 | Received 01 Apr 2021, Accepted 24 May 2021, Published online: 15 Jun 2021

Citations (24)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Elisa Giovannetti & Godefridus Peters. (2021) Beyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems. Expert Opinion on Drug Metabolism & Toxicology 17:8, pages 867-868.
Read now
Marilyn Silva. New approach methodologies (NAM) to characterize neurotoxic chemicals for use in risk assessment: case study of four neurotoxic pesticides. Human and Ecological Risk Assessment: An International Journal 0:0, pages 1-35.
Read now

Articles from other publishers (22)

Jo Nyffeler, Clinton Willis, Felix R. Harris, M.J. Foster, Bryant Chambers, Megan Culbreth, Richard E. Brockway, Sarah Davidson-Fritz, Daniel Dawson, Imran Shah, Katie Paul Friedman, Dan Chang, Logan J. Everett, John F. Wambaugh, Grace Patlewicz & Joshua A. Harrill. (2023) Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments. Toxicology and Applied Pharmacology 468, pages 116513.
Crossref
Marilyn Silva & Ryan Kin‐Hin Kwok. (2022) Use of computational toxicology models to predict toxicological points of departure: A case study with triazine herbicides. Birth Defects Research 115:5, pages 525-544.
Crossref
Matthew Boyce, Kristin A. Favela, Jessica A. Bonzo, Alex Chao, Lucina E. Lizarraga, Laura R. Moody, Elizabeth O. Owens, Grace Patlewicz, Imran Shah, Jon R. Sobus, Russell S. Thomas, Antony J. Williams, Alice Yau & John F. Wambaugh. (2023) Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis. Frontiers in Toxicology 5.
Crossref
Marina V. Evans, Thomas E. Moxon, Guoping Lian, Benjamin N. Deacon, Tao Chen, Linda D. Adams, Annabel Meade & John F. Wambaugh. (2023) A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin. Journal of Applied Toxicology.
Crossref
Anke Schneeweiss, Noël P. D. Juvigny‐Khenafou, Stephen Osakpolor, Andreas Scharmüller, Sebastian Scheu, Verena C. Schreiner, Roman Ashauer, Beate I. Escher, Florian Leese & Ralf B. Schäfer. (2022) Three perspectives on the prediction of chemical effects in ecosystems. Global Change Biology 29:1, pages 21-40.
Crossref
Celeste K. Carberry & Julia E. Rager. (2022) The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database‐driven review. Environmental and Molecular Mutagenesis 64:1, pages 50-66.
Crossref
Styliani Fragki, Aldert H. Piersma, Joost Westerhout, Anne Kienhuis, Nynke I. Kramer & Marco J. Zeilmaker. (2022) Applicability of generic PBK modelling in chemical hazard assessment: A case study with IndusChemFate. Regulatory Toxicology and Pharmacology 136, pages 105267.
Crossref
Abdulkarim Najjar, Ans Punt, John Wambaugh, Alicia Paini, Corie Ellison, Styliani Fragki, Enrica Bianchi, Fagen Zhang, Joost Westerhout, Dennis Mueller, Hequn Li, Quan Shi, Timothy W. Gant, Phil Botham, Rémi Bars, Aldert Piersma, Ben van Ravenzwaay & Nynke I. Kramer. (2022) Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment. Archives of Toxicology 96:12, pages 3407-3419.
Crossref
John F. Wambaugh & Julia E. Rager. (2022) Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment. Journal of Exposure Science & Environmental Epidemiology 32:6, pages 783-793.
Crossref
Miyuki Breen, John F. Wambaugh, Amanda Bernstein, Mark Sfeir & Caroline L. Ring. (2022) Simulating toxicokinetic variability to identify susceptible and highly exposed populations. Journal of Exposure Science & Environmental Epidemiology 32:6, pages 855-863.
Crossref
Carl Westmoreland, Hans J. Bender, John E. Doe, Miriam N. Jacobs, George E.N. Kass, Federica Madia, Catherine Mahony, Irene Manou, Gavin Maxwell, Pilar Prieto, Rob Roggeband, Tomasz Sobanski, Katrin Schütte, Andrew P. Worth, Zvonimir Zvonar & Mark T.D. Cronin. (2022) Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop. Regulatory Toxicology and Pharmacology 135, pages 105261.
Crossref
Gabriele Sabbioni, Argelia Castaño, Marta Esteban López, Thomas Göen, Hans Mol, Margaux Riou & Romuald Tagne-Fotso. (2022) Literature review and evaluation of biomarkers, matrices and analytical methods for chemicals selected in the research program Human Biomonitoring for the European Union (HBM4EU). Environment International 169, pages 107458.
Crossref
Lisa M. Sweeney. (2022) Case study on the impact of the source of metabolism parameters in next generation physiologically based pharmacokinetic models: Implications for occupational exposures to trimethylbenzenes. Regulatory Toxicology and Pharmacology 134, pages 105238.
Crossref
Dustin F. Kapraun, Mark Sfeir, Robert G Pearce, Sarah E Davidson-Fritz, Annie Lumen, André Dallmann, Richard S Judson & John F. Wambaugh. (2022) Evaluation of a rapid, generic human gestational dose model. Reproductive Toxicology 113, pages 172-188.
Crossref
Hisham El-Masri, Katie Paul Friedman, Kristin Isaacs & Barbara A. Wetmore. (2022) Advances in computational methods along the exposure to toxicological response paradigm. Toxicology and Applied Pharmacology 450, pages 116141.
Crossref
Kyle Roell, Lauren E. Koval, Rebecca Boyles, Grace Patlewicz, Caroline Ring, Cynthia V. Rider, Cavin Ward-Caviness, David M. Reif, Ilona Jaspers, Rebecca C. Fry & Julia E. Rager. (2022) Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research. Frontiers in Toxicology 4.
Crossref
George P Daston, Catherine Mahony, Russell S Thomas & Mathieu Vinken. (2022) Assessing Safety Without Animal Testing: The Road Ahead. Toxicological Sciences 187:2, pages 214-218.
Crossref
Xiaoqing Chang, Yu-Mei Tan, David G. Allen, Shannon Bell, Paul C. Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti J. Hakkinen, Shruti V. Kabadi, Nicole C. Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather A. Pangburn, Elijah J. Petersen, Emily N. Reinke, Alexandre J. S. Ribeiro, Nisha Sipes, Lisa M. Sweeney, John F. Wambaugh, Ronald Wange, Barbara A. Wetmore & Moiz Mumtaz. (2022) IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making. Toxics 10:5, pages 232.
Crossref
David E. Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen & Nicole Kleinstreuer. (2022) Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation. Frontiers in Pharmacology 13.
Crossref
Khaled Abass, Petri Reponen, Walaa F. Alsanie, Arja Rautio & Olavi Pelkonen. (2022) Metabolic profiling and in vitro-in vivo extrapolation of furathiocarb in mammalian hepatic microsomes. Toxicology Reports 9, pages 750-758.
Crossref
Marilyn Silva & Ryan Kin-Hin Kwok. (2022) Use of computational toxicology tools to predict in vivo endpoints associated with Mode of Action and the endocannabinoid system: A case study with chlorpyrifos, chlorpyrifos-oxon and Δ9Tetrahydrocannabinol. Current Research in Toxicology 3, pages 100064.
Crossref
Gabriele Sabbioni & Billy W. Day. (2021) Quo vadis blood protein adductomics?. Archives of Toxicology 96:1, pages 79-103.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.