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Expert Review of Medical Devices Volume 13, 2016 - Issue 12
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Review

Emerging point-of-care technologies for sickle cell disease screening and monitoring

Yunus AlapanCase Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH, USAView further author information
,
Arwa FraiwanCase Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH, USAView further author information
,
Erdem KucukalCase Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH, USAView further author information
,
M. Noman HasanCase Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH, USAView further author information
,
Ryan UngBiomedical Engineering Department, Case Western Reserve University, Cleveland, OH, USAView further author information
,
Myeongseop KimCase Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH, USAView further author information
,
Isaac OdameDivision of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada;Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, CanadaView further author information
,
Jane A. LittleDepartment of Hematology and Oncology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA;Seidman Cancer Center at University Hospitals, Case Medical Center, Cleveland, OH, USACorrespondence[email protected] [email protected]
View further author information
&
Umut A. GurkanCase Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH, USA;Biomedical Engineering Department, Case Western Reserve University, Cleveland, OH, USA;Department of Orthopedics, Case Western Reserve University, Cleveland, OH, USAView further author information
 show all
Pages 1073-1093 | Received 25 Jul 2016, Accepted 25 Oct 2016, Published online: 22 Nov 2016

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Emmanuel Tebandite Kasai, Jean Pierre Alworong’a Opara, Justin Ntokamunda Kadima, Masendu Kalenga, Salomon Batina Agasa, Roland Marini Djang’eing‘a & François Boemer. (2022) Overview of current progress and challenges in diagnosis, and management of pediatric sickle cell disease in Democratic Republic of the Congo. Hematology 27:1, pages 132-140.
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Kristen E. Howell, Andrew M. Heitzer, Jennifer N. Longoria, Brian Potter, Winfred C. Wang, Sheila Anderson, Guolian Kang, Jane S. Hankins & Jerlym S. Porter. (2022) Assessment of transition readiness to predict health care utilization during transition to adult care in sickle cell disease. Expert Review of Hematology 15:12, pages 1063-1072.
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Articles from other publishers (39)

Wjdan A. Arishi, Shimaa Eissa, Khaled Al-Kattan & Mohammed Zourob. (2023) Aptamer-based label-free electrochemical biosensors for the diagnosis of sickle cell anemia. Biosensors and Bioelectronics: X 14, pages 100389.
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Elna Saah & Burton L. Lesnick. (2023) Lung Ultrasound in Sickle Cell. Chest 163:6, pages 1351-1352.
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Salome Bwayo Weaver, Dhakrit Rungkitwattanakul & Divita Singh. (2021) Contemporary Management and Prevention of Vaso-Occlusive Crises (VOCs) in Adults With Sickle Cell Disease. Journal of Pharmacy Practice 36:1, pages 139-148.
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Isaac Odame. (2023) Sickle cell disease in children: an update of the evidence in low- and middle-income settings. Archives of Disease in Childhood 108:2, pages 108-114.
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Elna Saah, Payam Fadaei, Umut A. Gurkan & Vivien Sheehan. (2022) Sickle Cell Disease Pathophysiology and Related Molecular and Biophysical Biomarkers. Hematology/Oncology Clinics of North America 36:6, pages 1077-1095.
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Ran An, Yuning Huang, Anne Rocheleau, Alireza Avanaki, Priyaleela Thota, Qiaochu Zhang, Yuncheng Man, Zoe Sekyonda, Catherine I. Segbefia, Yvonne Dei-Adomakoh, Enoch Mensah, Kwaku Ohene-Frempong, Isaac Odame, Amma Owusu-Ansah & Umut A. Gurkan. (2022) Multispectral imaging for MicroChip electrophoresis enables point-of-care newborn hemoglobin variant screening. Heliyon 8:12, pages e11778.
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Ran An & Umut A. Gurkan. (2022) Emerging functional microfluidic assays for the study of thromboinflammation in sickle cell disease. Current Opinion in Hematology 29:6, pages 327-334.
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Yuncheng Man, Ran An, Karamoja Monchamp, Zoe Sekyonda, Erdem Kucukal, Chiara Federici, William J. Wulftange, Utku Goreke, Allison Bode, Vivien A. Sheehan & Umut A. Gurkan. (2022) OcclusionChip: A functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability. Frontiers in Physiology 13.
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Samuel Ademola Adegoke, Oluwatoyin Ibukun Oladimeji, Morenike Agnes Akinlosotu, Alex Ifeoluwa Akinwumi & Kayode Ademola Matthew. (2022) HemoTypeSC point-of-care testing shows high sensitivity with alkaline cellulose acetate hemoglobin electrophoresis for screening hemoglobin SS and SC genotypes. Hematology, Transfusion and Cell Therapy 44:3, pages 341-345.
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Shaurjya Mandal, Debanjan Das & Venkanna Udutalapally. (2022) mSickle: sickle cell identification through gradient evaluation and smartphone microscopy. Journal of Ambient Intelligence and Humanized Computing.
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Niksa Praljak, Shamreen Iram, Utku Goreke, Gundeep Singh, Ailis Hill, Umut A. Gurkan & Michael Hinczewski. (2021) Integrating deep learning with microfluidics for biophysical classification of sickle red blood cells adhered to laminin. PLOS Computational Biology 17:11, pages e1008946.
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Ran An, Yuncheng Man, Shamreen Iram, Erdem Kucukal, Muhammad Noman Hasan, Yuning Huang, Utku Goreke, Allison Bode, Ailis Hill, Kevin Cheng, Zoe Sekyonda, Sanjay P. Ahuja, Jane A. Little, Michael Hinczewski & Umut A. Gurkan. (2021) Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing. Lab on a Chip 21:20, pages 3863-3875.
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Valeria Rizzuto, Arianna Mencattini, Begoña Álvarez-González, Davide Di Giuseppe, Eugenio Martinelli, David Beneitez-Pastor, Maria del Mar Mañú-Pereira, Maria José Lopez-Martinez & Josep Samitier. (2021) Combining microfluidics with machine learning algorithms for RBC classification in rare hereditary hemolytic anemia. Scientific Reports 11:1.
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Christopher D. Brown, Alexey M. Aprelev, Maura Aliprando, Emily A. Harkness & Frank A. Ferrone. (2021) The flow of sickle blood in glass capillaries: Fundamentals and potential applications. Biophysical Journal 120:11, pages 2138-2147.
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Ran An, Yuning Huang, Yuncheng Man, Russell W. Valentine, Erdem Kucukal, Utku Goreke, Zoe Sekyonda, Connie Piccone, Amma Owusu-Ansah, Sanjay Ahuja, Jane A. Little & Umut A. Gurkan. (2021) Emerging point-of-care technologies for anemia detection. Lab on a Chip 21:10, pages 1843-1865.
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Wjdan A. Arishi, Hani A. Alhadrami & Mohammed Zourob. (2021) Techniques for the Detection of Sickle Cell Disease: A Review. Micromachines 12:5, pages 519.
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Umut A. Gurkan. (2021) Biophysical and rheological biomarkers of red blood cell physiology and pathophysiology. Current Opinion in Hematology 28:3, pages 138-149.
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Soh Young Ryu, Carola-Ellen Kleine, Jui-Ting Hsiung, Christina Park, Connie M Rhee, Hamid Moradi, Ramy Hanna, Kamyar Kalantar-Zadeh & Elani Streja. (2021) Association of lactate dehydrogenase with mortality in incident hemodialysis patients. Nephrology Dialysis Transplantation 36:4, pages 704-712.
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Anupam Aich, Yann Lamarre, Daniel Pereira Sacomani, Simone Kashima, Dimas Tadeu Covas & Lucimara Gaziola de la Torre. (2021) Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem. Frontiers in Molecular Biosciences 7.
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Konathala Geethakumari, Yadlapalli S. Kusuma & Bontha V. Babu. (2020) Beyond the screening: The need for health systems intervention for prevention and management of sickle cell disease among tribal population of India. The International Journal of Health Planning and Management 36:2, pages 236-243.
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Bridgette Stasher-Booker, Danita Stapleton & Greshundria M. Raines. (2021) The Use of Smartphone Technology to Improve the Health of Sickle Cell Patients. Journal of Public Health Issues and Practices 5:2.
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Kelli Qua, Shannon M. Swiatkowski, Umut A. Gurkan & Clara M. Pelfrey. (2021) A retrospective case study of successful translational research: Gazelle Hb variant point-of-care diagnostic device for sickle cell disease. Journal of Clinical and Translational Science 5:1.
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Roberta Risoluti, Patrizia Caprari, Giuseppina Gullifa, Sara Massimi, Francesco Sorrentino, Laura Maffei & Stefano Materazzi. (2020) Innovative screening test for the early detection of sickle cell anemia. Talanta 219, pages 121243.
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Erdem Kucukal, Yuncheng Man, Ailis Hill, Shichen Liu, Allison Bode, Ran An, Jaikrishnan Kadambi, Jane A. Little & Umut A. Gurkan. (2020) Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease. American Journal of Hematology 95:11, pages 1246-1256.
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Shazia Ilyas, Mazhar Sher, E. Du & Waseem Asghar. (2020) Smartphone-based sickle cell disease detection and monitoring for point-of-care settings. Biosensors and Bioelectronics 165, pages 112417.
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Timothy O’Connor, Arun Anand, Biree Andemariam & Bahram Javidi. (2020) Deep learning-based cell identification and disease diagnosis using spatio-temporal cellular dynamics in compact digital holographic microscopy. Biomedical Optics Express 11:8, pages 4491.
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Yuncheng Man, Erdem Kucukal, Ran An, Quentin D. Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A. Little & Umut A. Gurkan. (2020) Microfluidic assessment of red blood cell mediated microvascular occlusion. Lab on a Chip 20:12, pages 2086-2099.
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Kevin de Haan, Hatice Ceylan Koydemir, Yair Rivenson, Derek Tseng, Elizabeth Van Dyne, Lissette Bakic, Doruk Karinca, Kyle Liang, Megha Ilango, Esin Gumustekin & Aydogan Ozcan. (2020) Automated screening of sickle cells using a smartphone-based microscope and deep learning. npj Digital Medicine 3:1.
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Yunus Alapan, Ugur Bozuyuk, Pelin Erkoc, Alp Can Karacakol & Metin Sitti. (2020) Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow. Science Robotics 5:42.
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Muhammad Noman Hasan, Arwa Fraiwan, Ran An, Yunus Alapan, Ryan Ung, Asya Akkus, Julia Z. Xu, Amy J. Rezac, Nicholas J. Kocmich, Melissa S. Creary, Tolulope Oginni, Grace Mfon Olanipekun, Fatimah Hassan-Hanga, Binta W. Jibir, Safiya Gambo, Anil K. Verma, Praveen K. Bharti, Suchada Riolueang, Takdanai Ngimhung, Thidarat Suksangpleng, Priyaleela Thota, Greg Werner, Rajasubramaniam Shanmugam, Aparup Das, Vip Viprakasit, Connie M. Piccone, Jane A. Little, Stephen K. Obaro & Umut A. Gurkan. (2020) Paper-based microchip electrophoresis for point-of-care hemoglobin testing. The Analyst 145:7, pages 2525-2542.
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Ran An, Muhammad Noman Hasan, Yuncheng Man & Umut A. Gurkan. (2019) Integrated Point-of-Care Device for Anemia Detection and Hemoglobin Variant Identification. Integrated Point-of-Care Device for Anemia Detection and Hemoglobin Variant Identification.
Yunus AlapanOncay YasaBerk YigitI. Ceren YasaPelin ErkocMetin Sitti. (2019) Microrobotics and Microorganisms: Biohybrid Autonomous Cellular Robots. Annual Review of Control, Robotics, and Autonomous Systems 2:1, pages 205-230.
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Joy Mburu & Isaac Odame. (2019) Sickle cell disease: Reducing the global disease burden. International Journal of Laboratory Hematology 41:S1, pages 82-88.
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Tracy Bonsu Osei, Charles Apprey, Felix Charles Mills-Robertson & Agartha N. Ohemeng. (2019) Nutritional status of children with sickle cell disease. Nutrition & Food Science 49:2, pages 232-239.
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Elain Fu. 2019. Applications of Microfluidic Systems in Biology and Medicine. Applications of Microfluidic Systems in Biology and Medicine 325 352 .
Erdem Kucukal, Jane A. Little & Umut A. Gurkan. (2018) Shear dependent red blood cell adhesion in microscale flow. Integrative Biology 10:4, pages 194-206.
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Patrick T. McGann & Carolyn Hoppe. (2017) The pressing need for point-of-care diagnostics for sickle cell disease: A review of current and future technologies. Blood Cells, Molecules, and Diseases 67, pages 104-113.
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Myeongseop Kim, Yunus Alapan, Anima Adhikari, Jane A. Little & Umut A. Gurkan. (2017) Hypoxia‐enhanced adhesion of red blood cells in microscale flow. Microcirculation 24:5.
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John C. Krebs, Yunus Alapan, Barbara A. Dennstedt, Glenn D. Wera & Umut A. Gurkan. (2017) Microfluidic processing of synovial fluid for cytological analysis. Biomedical Microdevices 19:2.
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