Advanced search
Publication Cover
Nanotoxicology Volume 11, 2017 - Issue 6
Submit an article Journal homepage
940
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress

Marie DorierChimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST), INAC, SyMMES, University of Grenoble Alpes, Grenoble, France; ;Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST), CEA, INAC, LCIB, Grenoble, France; View further author information
,
David BéalChimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST), INAC, SyMMES, University of Grenoble Alpes, Grenoble, France; ;Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST), CEA, INAC, LCIB, Grenoble, France; View further author information
,
Caroline Marie-DesvergneNanosafety Platform, Medical Biology Laboratory (LBM), CEA, University of Grenoble Alpes, Grenoble, France; View further author information
,
Muriel DubossonNanosafety Platform, Medical Biology Laboratory (LBM), CEA, University of Grenoble Alpes, Grenoble, France; View further author information
,
Frédérick BarreauINSERM, UMR1220, Institut de Recherche en Santé Digestive, Toulouse, France; ORCID Iconhttp://orcid.org/0000-0002-7150-9619View further author information
ORCID Icon,
Eric HoudeauToxalim (Research Center in Food Toxicology), Department Intestinal Development, Xeniobiotics and ImmunoToxicology, Université de Toulouse, INRA, ENVT, INP-Purpan, Toulouse, France; ;UPS, UMR1331, Toxalim, Université de Toulouse, Toulouse, France; ORCID Iconhttp://orcid.org/0000-0003-1971-9827View further author information
ORCID Icon,
Nathalie Herlin-BoimeNIMBE, CEA, CNRS, Université Paris-Saclay, Saclay, FranceView further author information
&
Marie CarriereChimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST), INAC, SyMMES, University of Grenoble Alpes, Grenoble, France; ;Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST), CEA, INAC, LCIB, Grenoble, France; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8446-6462View further author information
ORCID Icon show all
Pages 751-761 | Received 25 Nov 2016, Accepted 24 Jun 2017, Published online: 19 Jul 2017

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Julien Vignard, Aurelie Pettes-Duler, Eric Gaultier, Christel Cartier, Laurent Weingarten, Antje Biesemeier, Tatjana Taubitz, Philippe Pinton, Cecilia Bebeacua, Laurent Devoille, Jacques Dupuy, Elisa Boutet-Robinet, Nicolas Feltin, Isabelle P. Oswald, Fabrice H. Pierre, Bruno Lamas, Gladys Mirey & Eric Houdeau. (2023) Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium. Nanotoxicology 17:4, pages 289-309.
Read now
Kornphimol Kulthong, Guido J. E. J. Hooiveld, Loes P. M. Duivenvoorde, Ignacio Miro Estruch, Hans Bouwmeester & Meike van der Zande. (2021) Comparative study of the transcriptomes of Caco-2 cells cultured under dynamic vs. static conditions following exposure to titanium dioxide and zinc oxide nanomaterials. Nanotoxicology 15:9, pages 1233-1252.
Read now
Yanjun Gao, Yixuan Ye, Jing Wang, Hao Zhang, Yao Wu, Yihui Wang, Lailai Yan, Yongliang Zhang, Shumin Duan, Lizhi Lv & Yun Wang. (2020) Effects of titanium dioxide nanoparticles on nutrient absorption and metabolism in rats: distinguishing the susceptibility of amino acids, metal elements, and glucose. Nanotoxicology 14:10, pages 1301-1323.
Read now
Peter Møller, Ditte Marie Jensen, Regitze Sølling Wils, Maria Helena Guerra Andersen, Pernille Høgh Danielsen & Martin Roursgaard. (2017) Assessment of evidence for nanosized titanium dioxide-generated DNA strand breaks and oxidatively damaged DNA in cells and animal models. Nanotoxicology 11:9-10, pages 1237-1256.
Read now

Articles from other publishers (45)

Caroline Carlé, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanuel Mas, Marie Carriere, Ziad Al Nabhani & Frédérick Barreau. (2023) Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life. Particle and Fibre Toxicology 20:1.
Crossref
Ozan Akdogan, Canan Bagci, Nilay Gunduz Akdogan & Sedef Ozunlu. 2023. Nanoparticles as Sustainable Environmental Remediation Agents. Nanoparticles as Sustainable Environmental Remediation Agents 193 237 .
Shumin Duan, Hongbo Wang, Yanjun Gao, Xiang Wang, Lizhi Lyu & Yun Wang. (2023) Oral intake of titanium dioxide nanoparticles affect the course and prognosis of ulcerative colitis in mice: involvement of the ROS-TXNIP-NLRP3 inflammasome pathway. Particle and Fibre Toxicology 20:1.
Crossref
Ayşegül TAŞÇIOĞLU & Gökhan YILMAZ. (2022) Degradation evaluation of titanium dioxide under stress factorsTitanyum dioksitin stres faktörleri altında bozunma değerlendirmesi. Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi.
Crossref
Thomas Sauvaitre, Josefien Van Landuyt, Claude Durif, Charlène Roussel, Adeline Sivignon, Sandrine Chalancon, Ophélie Uriot, Florence Van Herreweghen, Tom Van de Wiele, Lucie Etienne-Mesmin & Stéphanie Blanquet-Diot. (2022) Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome. npj Biofilms and Microbiomes 8:1.
Crossref
Raphaël Cornu, Arnaud Béduneau & Hélène Martin. (2022) Ingestion of titanium dioxide nanoparticles: a definite health risk for consumers and their progeny. Archives of Toxicology 96:10, pages 2655-2686.
Crossref
Dilek AŞCI ÇELİK, Vehbi Atahan TOĞAY, Gülçin YAVUZ TÜREL & Nurten ÖZÇELİK. (2022) GIDA KATKI MADDESİ OLARAK KULLANILAN SİTRİK ASİT, ASKORBİK ASİT VE SODYUM SİTRATIN İNSAN LENFOSİT HÜCRELERİNDE GENOTOKSİSİTESİNİN DEĞERLENDİRİLMESİGENOTOXICITY EVALUATION OF CITRIC ACID, ASCORBIC ACID AND SODIUM CITRATE USED AS FOOD ADDITIVES IN HUMAN LYMPHOCYTES. SDÜ Tıp Fakültesi Dergisi 29:3, pages 486-492.
Crossref
Dora Rolo, Ricardo Assunção, Célia Ventura, Paula Alvito, Lídia Gonçalves, Carla Martins, Ana Bettencourt, Peter Jordan, Nádia Vital, Joana Pereira, Fátima Pinto, Paulo Matos, Maria João Silva & Henriqueta Louro. (2022) Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials 12:19, pages 3275.
Crossref
Zaira Colin-Val, Carlos Daniel Vera-Márquez, Manuel Alejandro Herrera-Rodríguez, María del Pilar Ramos-Godinez, Alejandro López-Saavedra, Agustina Cano-Martínez, Diana Xochiquetzal Robledo-Cadena, Sara Rodríguez-Enríquez, Francisco Correa, Norma Laura Delgado‐Buenrostro, Yolanda I. Chirino & Rebeca López-Marure. (2022) Titanium Dioxide (E171) Induces Toxicity in H9c2 Rat Cardiomyoblasts and Ex Vivo Rat Hearts. Cardiovascular Toxicology 22:8, pages 713-726.
Crossref
Ewa Baranowska-Wójcik, Dominik Szwajgier & Anna Winiarska-Mieczan. (2022) A review of research on the impact of E171/TiO2 NPs on the digestive tract. Journal of Trace Elements in Medicine and Biology 72, pages 126988.
Crossref
Thomas Sauvaitre, Florence Van Herreweghen, Karen Delbaere, Claude Durif, Josefien Van Landuyt, Khaled Fadhlaoui, Ségolène Huille, Frédérique Chaucheyras-Durand, Lucie Etienne-Mesmin, Stéphanie Blanquet-Diot & Tom Van de Wiele. (2022) Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence?. Nutrients 14:10, pages 2146.
Crossref
Anca Diana Racovita. (2022) Titanium Dioxide: Structure, Impact, and Toxicity. International Journal of Environmental Research and Public Health 19:9, pages 5681.
Crossref
Manuela Vitulo, Elisa Gnodi, Raffaella Meneveri & Donatella Barisani. (2022) Interactions between Nanoparticles and Intestine. International Journal of Molecular Sciences 23:8, pages 4339.
Crossref
Adriana Vieira, Nádia Vital, Dora Rolo, Rossana Roque, Lídia M. Gonçalves, Ana Bettencourt, Maria João Silva & Henriqueta Louro. (2022) Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells. Food and Chemical Toxicology 161, pages 112841.
Crossref
Igor Pravst, Maša Hribar, Katja Žmitek, Bojan Blažica, Barbara Koroušić Seljak & Anita Kušar. (2022) Branded Foods Databases as a Tool to Support Nutrition Research and Monitoring of the Food Supply: Insights From the Slovenian Composition and Labeling Information System. Frontiers in Nutrition 8.
Crossref
Adriana Vieira, Ana Gramacho, Dora Rolo, Nádia Vital, Maria João Silva & Henriqueta Louro. 2022. Nanotoxicology in Safety Assessment of Nanomaterials. Nanotoxicology in Safety Assessment of Nanomaterials 225 257 .
Frédérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand & Marie Carriere. (2021) Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer. Particle and Fibre Toxicology 18:1.
Crossref
Yongliang Zhang, Shumin Duan, Ying Liu & Yun Wang. (2021) The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs. Particle and Fibre Toxicology 18:1.
Crossref
Romain Vian, Hamideh Salehi, Marion Lapierre, Fréderic Cuisinier, Vincent Cavaillès & Sébastien Balme. (2021) Adsorption of proteins on TiO2 particles influences their aggregation and cell penetration. Food Chemistry 360, pages 130003.
Crossref
Thomas Sauvaitre, Claude Durif, Adeline Sivignon, Sandrine Chalancon, Tom Van de Wiele, Lucie Etienne-Mesmin & Stéphanie Blanquet-Diot. (2021) In Vitro Evaluation of Dietary Fiber Anti-Infectious Properties against Food-Borne Enterotoxigenic Escherichia coli. Nutrients 13:9, pages 3188.
Crossref
Sazada Siddiqui & Sulaiman A. Alrumman. (2021) Influence of nanoparticles on food: An analytical assessment. Journal of King Saud University - Science 33:6, pages 101530.
Crossref
Urška Blaznik, Sanja Krušič, Maša Hribar, Anita Kušar, Katja Žmitek & Igor Pravst. (2021) Use of Food Additive Titanium Dioxide (E171) before the Introduction of Regulatory Restrictions Due to Concern for Genotoxicity. Foods 10:8, pages 1910.
Crossref
Wei Liao, Waisudin Badri, Emilie Dumas, Sami Ghnimi, Abdelhamid Elaissari, Rémi Saurel & Adem Gharsallaoui. (2021) Nanoencapsulation of Essential Oils as Natural Food Antimicrobial Agents: An Overview. Applied Sciences 11:13, pages 5778.
Crossref
Emanuele Rinninella, Marco Cintoni, Pauline Raoul, Vincenzina Mora, Antonio Gasbarrini & Maria Cristina Mele. (2021) Impact of Food Additive Titanium Dioxide on Gut Microbiota Composition, Microbiota-Associated Functions, and Gut Barrier: A Systematic Review of In Vivo Animal Studies. International Journal of Environmental Research and Public Health 18:4, pages 2008.
Crossref
Merry Ghebretatios, Sabrina Schaly & Satya Prakash. (2021) Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases. International Journal of Molecular Sciences 22:4, pages 1942.
Crossref
Yuanfang Zheng & Bernd Nowack. (2021) Size-Specific, Dynamic, Probabilistic Material Flow Analysis of Titanium Dioxide Releases into the Environment. Environmental Science & Technology 55:4, pages 2392-2402.
Crossref
Nicolaj S. Bischoff, Theo M. de Kok, Dick T.H.M. Sijm, Simone G. van Breda, Jacco J. Briedé, Jacqueline J.M. Castenmiller, Antoon Opperhuizen, Yolanda I. Chirino, Hubert Dirven, David Gott, Eric Houdeau, Agnes G. Oomen, Morten Poulsen, Gerhard Rogler & Henk van Loveren. (2020) Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System. International Journal of Molecular Sciences 22:1, pages 207.
Crossref
A. Guillard, E. Gaultier, C. Cartier, L. Devoille, J. Noireaux, L. Chevalier, M. Morin, F. Grandin, M. Z. Lacroix, C. Coméra, A. Cazanave, A. de Place, V. Gayrard, V. Bach, K. Chardon, N. Bekhti, K. Adel-Patient, C. Vayssière, P. Fisicaro, N. Feltin, F. de la Farge, N. Picard-Hagen, B. Lamas & E. Houdeau. (2020) Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model. Particle and Fibre Toxicology 17:1.
Crossref
Christine Coméra, Christel Cartier, Eric Gaultier, Olivier Catrice, Quentin Panouille, Sarah El Hamdi, Kristof Tirez, Inge Nelissen, Vassilia Théodorou & Eric Houdeau. (2020) Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice. Particle and Fibre Toxicology 17:1.
Crossref
Dhanya T. Jayaram & Christine K. Payne. (2020) Food-Grade TiO 2 Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells . Chemical Research in Toxicology 33:11, pages 2872-2879.
Crossref
Arianna Marucco, Marion Prono, David Beal, Enrica Alasonati, Paola Fisicaro, Enrico Bergamaschi, Marie Carriere & Ivana Fenoglio. (2020) Biotransformation of Food-Grade and Nanometric TiO2 in the Oral–Gastro–Intestinal Tract: Driving Forces and Effect on the Toxicity toward Intestinal Epithelial Cells. Nanomaterials 10:11, pages 2132.
Crossref
Pauline Franz, Alexander Bürkle, Peter Wick & Cordula Hirsch. (2020) Exploring Flow Cytometry-Based Micronucleus Scoring for Reliable Nanomaterial Genotoxicity Assessment. Chemical Research in Toxicology 33:10, pages 2538-2549.
Crossref
Ana Bettencourt, Lídia M. Gonçalves, Ana C. Gramacho, Adriana Vieira, Dora Rolo, Carla Martins, Ricardo Assunção, Paula Alvito, Maria João Silva & Henriqueta Louro. (2020) Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion. Nanomaterials 10:8, pages 1516.
Crossref
Saeko Tada-Oikawa, Mana Eguchi, Michiko Yasuda, Kiyora Izuoka, Akihiko Ikegami, Sandra Vranic, Sonja Boland, Lang Tran, Gaku Ichihara & Sahoko Ichihara. (2020) Functionalized Surface-Charged SiO 2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells . Chemical Research in Toxicology 33:5, pages 1226-1236.
Crossref
Xiaoqiong Cao, Tong Zhang, Glen M. DeLoid, Matthew J. Gaffrey, Karl K. Weitz, Brian D. Thrall, Wei-Jun Qian & Philip Demokritou. (2020) Evaluation of the cytotoxic and cellular proteome impacts of food-grade TiO2 (E171) using simulated gastrointestinal digestions and a tri-culture small intestinal epithelial model. NanoImpact 17, pages 100202.
Crossref
Héloïse Proquin, Marloes C. M. Jonkhout, Marlon J. Jetten, Henk van Loveren, Theo M. de Kok & Jacob J. Briedé. (2019) Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles. Scientific Reports 9:1.
Crossref
Ji-Soo Hwang, Jin Yu, Hyoung-Mi Kim, Jae-Min Oh & Soo-Jin Choi. (2019) Food Additive Titanium Dioxide and Its Fate in Commercial Foods. Nanomaterials 9:8, pages 1175.
Crossref
Susanne Fritsch-Decker, Zhen An, Jin Yan, Iris Hansjosten, Marco Al-Rawi, Ravindra Peravali, Silvia Diabaté & Carsten Weiss. (2019) Silica Nanoparticles Provoke Cell Death Independent of p53 and BAX in Human Colon Cancer Cells. Nanomaterials 9:8, pages 1172.
Crossref
Jean-Marie Teulon, Christian Godon, Louis Chantalat, Christine Moriscot, Julien Cambedouzou, Michael Odorico, Johann Ravaux, Renaud Podor, Adèle Gerdil, Aurélie Habert, Nathalie Herlin-Boime, Shu-wen Chen & Jean-Luc Pellequer. (2018) On the Operational Aspects of Measuring Nanoparticle Sizes. Nanomaterials 9:1, pages 18.
Crossref
Héloïse Proquin, Marlon J. Jetten, Marloes C. M. Jonkhout, Luis Guillermo Garduño-Balderas, Jacob J. Briedé, Theo M. de Kok, Henk van Loveren & Yolanda I. Chirino. (2018) Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer. Scientific Reports 8:1.
Crossref
Kévin Gillois, Mathilde Lévêque, Vassilia Théodorou, Hervé Robert & Muriel Mercier-Bonin. (2018) Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives. Microorganisms 6:2, pages 53.
Crossref
Joanna M. Radziwill-Bienkowska, Pauline Talbot, Jasper B. J. Kamphuis, Véronique Robert, Christel Cartier, Isabelle Fourquaux, Esther Lentzen, Jean-Nicolas Audinot, Frédéric Jamme, Matthieu Réfrégiers, Jacek K. Bardowski, Philippe Langella, Magdalena Kowalczyk, Eric Houdeau, Muriel Thomas & Muriel Mercier-Bonin. (2018) Toxicity of Food-Grade TiO2 to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging. Frontiers in Microbiology 9.
Crossref
Verónica Freyre-Fonseca, Estefany I. Medina-Reyes, Darío I. Téllez-Medina, Gloria L. Paniagua-Contreras, Eric Monroy-Pérez, Felipe Vaca-Paniagua, Norma L. Delgado-Buenrostro, José O. Flores-Flores, Edgar O. López-Villegas, Gustavo F. Gutiérrez-López & Yolanda I. Chirino. (2018) Influence of shape and dispersion media of titanium dioxide nanostructures on microvessel network and ossification. Colloids and Surfaces B: Biointerfaces 162, pages 193-201.
Crossref
Héloïse Proquin, Marlon J. Jetten, Marloes C.M. Jonkhout, Luis G. Garduño-Balderas, Jacob J. Briedé, Theo M. de Kok, Yolanda I. Chirino & Henk van Loveren. (2018) Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171). Food and Chemical Toxicology 111, pages 153-165.
Crossref
Glen M. DeLoid, Yanli Wang, Klara Kapronezai, Laura Rubio Lorente, Roujie Zhang, Georgios Pyrgiotakis, Nagarjun V. Konduru, Maria Ericsson, Jason C. White, Roberto De La Torre-Roche, Hang Xiao, David Julian McClements & Philip Demokritou. (2017) An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials. Particle and Fibre Toxicology 14:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.