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Nanotoxicology Volume 12, 2018 - Issue 7
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Article

Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month

Marit IlvesFaculty of Medicine, University of Helsinki, Helsinki, Finland; ORCID Iconhttp://orcid.org/0000-0003-1334-9001View further author information
ORCID Icon,
Sara VilskeFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Kukka AimonenFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Hanna K. LindbergFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Saila PesonenFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Irene WedinStora Enso Oyj, Helsinki, Finland; View further author information
,
Markus NuopponenUPM Kymmene Oyj, Helsinki, Finland; View further author information
,
Esa VanhalaFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Casper HøjgaardLiderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark; View further author information
,
Jakob R. WintherLiderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark; View further author information
,
Martin WillemoësLiderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark; View further author information
,
Ulla VogelNational Research Centre for the Working Environment, Copenhagen, Denmark; View further author information
,
Henrik WolffFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Hannu NorppaFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
,
Kai SavolainenFinnish Institute of Occupational Health, Helsinki, Finland; View further author information
&
Harri AleniusFaculty of Medicine, University of Helsinki, Helsinki, Finland; ;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenCorrespondence[email protected]
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Pages 729-746 | Received 31 Aug 2017, Accepted 26 Apr 2018, Published online: 30 May 2018

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Natasha Stoudmann, Mélanie Schmutz, Cordula Hirsch, Bernd Nowack & Claudia Som. (2020) Human hazard potential of nanocellulose: quantitative insights from the literature. Nanotoxicology 14:9, pages 1241-1257.
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Li-Ying Song, Yun-Zhou Wu, Xi-Xiang Pei, Rui Li, Hai-Tao Chen & Xiao-Zheng Sun. (2020) Pulmonary toxicity and RNA sequencing analyses of mouse in response to exposure to cellulose nanofibrils. Inhalation Toxicology 32:9-10, pages 388-401.
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Takafumi Sai & Katsuhide Fujita. (2020) A review of pulmonary toxicity studies of nanocellulose. Inhalation Toxicology 32:6, pages 231-239.
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Articles from other publishers (28)

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Alina Ghilan, Raluca Nicu, Diana E. Ciolacu & Florin Ciolacu. (2023) Insight into the Latest Medical Applications of Nanocellulose. Materials 16:12, pages 4447.
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Ivan V. Gmoshinski, Vladimir A. Schipelin & Sergey A. Khotimchenko. (2023) Nanocelluloses: hazard characteristics and possible risks (literature review). Hygiene and sanitation 102:2, pages 181-190.
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Isamu Ogura, Katsuhide Fujita, Masanori Horie, Akihiro Moriyama, Rie Tai & Hiroyuki Mano. (2023) Current Knowledge on the Safety of Cellulose Nanofibersセルロースナノファイバーの安全性に関するこれまでの研究. Seikei-Kakou 35:4, pages 122-125.
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Simon Wieland, Aylin Balmes, Julian Bender, Jonas Kitzinger, Felix Meyer, Anja FRM Ramsperger, Franz Roeder, Caroline Tengelmann, Benedikt H. Wimmer, Christian Laforsch & Holger Kress. (2022) From properties to toxicity: Comparing microplastics to other airborne microparticles. Journal of Hazardous Materials 428, pages 128151.
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Leo Bey Fen, Jahangir Kamaldin & Hazirah Pengiran. 2022. Industrial Applications of Nanocellulose and Its Nanocomposites. Industrial Applications of Nanocellulose and Its Nanocomposites 245 261 .
Gurudatta Singh, Syed Saquib, Ankita Gupta & Swati. 2022. Nanocellulose Materials. Nanocellulose Materials 265 288 .
Haziqatulhanis Ibrahim, Norazlianie Sazali, Wan Norharyati Wan Salleh & Rishen Nair Krishnan. 2022. Enabling Industry 4.0 through Advances in Manufacturing and Materials. Enabling Industry 4.0 through Advances in Manufacturing and Materials 109 115 .
Gary Chinga-Carrasco, Jennifer Rosendahl & Julia Catalán. 2022. Nanotoxicology in Safety Assessment of Nanomaterials. Nanotoxicology in Safety Assessment of Nanomaterials 155 177 .
Raluca Nicu, Florin Ciolacu & Diana E. Ciolacu. (2021) Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications. Pharmaceutics 13:8, pages 1125.
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Katsuhide Fujita, Sawae Obara, Junko Maru & Shigehisa Endoh. (2021) Pulmonary inflammation following intratracheal instillation of cellulose nanofibrils in rats: comparison with multi-walled carbon nanotubes. Cellulose 28:11, pages 7143-7164.
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Hippolyte Durand, Megan Smyth & Julien Bras. 2021. Biopolymers for Biomedical and Biotechnological Applications. Biopolymers for Biomedical and Biotechnological Applications 129 179 .
Kukka Aimonen, Satu Suhonen, Mira Hartikainen, Viviana R. Lopes, Hannu Norppa, Natalia Ferraz & Julia Catalán. (2021) Role of Surface Chemistry in the In Vitro Lung Response to Nanofibrillated Cellulose. Nanomaterials 11:2, pages 389.
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Cong Liu, Jinxiang Zhao, Xu Zhang, Guanyun Wei, Wenjin Hao, Xin Wang, Chao Yang, Yunwei Shi & Dong Liu. (2020) Biomass-derived cellulose nanoparticles display considerable neurotoxicity in zebrafish. International Journal of Biological Macromolecules 165, pages 1783-1792.
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Isamu Ogura, Mari Kotake, Taichi Kuboyama & Hideo Kajihara. (2020) Measurements of cellulose nanofiber emissions and potential exposures at a production facility. NanoImpact 20, pages 100273.
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Célia Ventura, Fátima Pinto, Ana Filipa Lourenço, Paulo J. T. Ferreira, Henriqueta Louro & Maria João Silva. (2020) On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models. Cellulose 27:10, pages 5509-5544.
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Yingjia Chen, Yu-Ju Lin, Tamas Nagy, Fanbin Kong & Tai L. Guo. (2020) Subchronic exposure to cellulose nanofibrils induces nutritional risk by non-specifically reducing the intestinal absorption. Carbohydrate Polymers 229, pages 115536.
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Harri Alenius & Kai Savolainen. 2020. Interaction of Nanomaterials with the Immune System. Interaction of Nanomaterials with the Immune System 149 165 .
Katja Maria Bendtsen, Anders Brostrøm, Antti Joonas Koivisto, Ismo Koponen, Trine Berthing, Nicolas Bertram, Kirsten Inga Kling, Miikka Dal Maso, Oskari Kangasniemi, Mikko Poikkimäki, Katrin Loeschner, Per Axel Clausen, Henrik Wolff, Keld Alstrup Jensen, Anne Thoustrup Saber & Ulla Vogel. (2019) Airport emission particles: exposure characterization and toxicity following intratracheal instillation in mice. Particle and Fibre Toxicology 16:1.
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Pawan Kumar Mishra, Adam Ekielski, Sumit Mukherjee, Swetapadma Sahu, Saptarshi Chowdhury, Monalisa Mishra, Sushama Talegaonkar, Lubna Siddiqui & Harshita Mishra. (2019) Wood-Based Cellulose Nanofibrils: Haemocompatibility and Impact on the Development and Behaviour of Drosophila melanogaster. Biomolecules 9:8, pages 363.
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Maryam Salari, Dimitrios Bitounis, Kunal Bhattacharya, Georgios Pyrgiotakis, Zhenyuan Zhang, Emilia Purington, William Gramlich, Yohann Grondin, Rick Rogers, Douglas Bousfield & Philip Demokritou. (2019) Development & characterization of fluorescently tagged nanocellulose for nanotoxicological studies. Environmental Science: Nano 6:5, pages 1516-1526.
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James Ede, Kimberly Ong, Michael Goergen, Alan Rudie, Cassidy Pomeroy-Carter & Jo Shatkin. (2019) Risk Analysis of Cellulose Nanomaterials by Inhalation: Current State of Science. Nanomaterials 9:3, pages 337.
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Niels Hadrup, Kristina Bram Knudsen, Trine Berthing, Henrik Wolff, Stefan Bengtson, Christian Kofoed, Roall Espersen, Casper Højgaard, Jakob Rahr Winther, Martin Willemoës, Irene Wedin, Markus Nuopponen, Harri Alenius, Hannu Norppa, Håkan Wallin & Ulla Vogel. (2019) Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses. Environmental Toxicology and Pharmacology 66, pages 116-125.
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