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Nanotoxicology Volume 13, 2019 - Issue 8
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Articles

Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status

Laura TalaminiDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0001-6010-2947View further author information
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Sara GimondiDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0002-6660-0477View further author information
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Martina B. ViolattoDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0002-9016-410XView further author information
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Fabio FiordalisoDepartment of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; View further author information
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Federica PedicaDivision of Molecular Oncology, IRCCS San Raffaele Scientific Institute, Milano, Italy; View further author information
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Ngoc Lan TranDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy; View further author information
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Giovanni SitiaDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy; View further author information
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Federica AureliDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità-National Institute of Health, Rome, Italy; ORCID Iconhttp://orcid.org/0000-0002-0601-5807View further author information
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Andrea RaggiDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità-National Institute of Health, Rome, Italy; View further author information
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Inge NelissenHealth Department, Flemish Institute for Technological Research (VITO), Mol, BelgiumView further author information
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Francesco CubaddaDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità-National Institute of Health, Rome, Italy; ORCID Iconhttp://orcid.org/0000-0003-3454-7947View further author information
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Paolo BiginiDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0002-0239-9532View further author information
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Luisa DiomedeDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2258-0531View further author information
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Pages 1087-1101 | Received 24 Jan 2019, Accepted 22 May 2019, Published online: 22 Jul 2019

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Walter Brand, Ruud J. B. Peters, Hedwig M. Braakhuis, Lidka Maślankiewicz & Agnes G. Oomen. (2020) Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure. Nanotoxicology 14:7, pages 985-1007.
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Crossref
Yasmina M. Abd-Elhakim, Mohamed M.M. Hashem, Khaled Abo-EL-Sooud, Mohamed R. Mousa, Ahmed M. Soliman, Samar M. Mouneir, Sameh H. Ismail, Bayan A. Hassan & Hayat H.M. El-Nour. (2023) Interactive effects of cadmium and titanium dioxide nanoparticles on hepatic tissue in rats: Ameliorative role of coenzyme 10 via modulation of the NF-κB and TNFα pathway. Food and Chemical Toxicology 182, pages 114191.
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Ying Ma, Nairui Yu, Huaye Lu, Jiaqi Shi, Yi Zhang, Zhangjian Chen & Guang Jia. (2023) Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota. Archives of Toxicology 97:8, pages 2051-2067.
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Yaowen Liu, Ying Huang, Yang Cao, Xinjie Hu, Suqing Li, Jianwu Dai, KangJu Lee & Wen Qin. (2022) Characterization and assessment of potential risks of titanium dioxide nanoparticles isolated from gummy candies. Journal of Cleaner Production 373, pages 133829.
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Shuyuan Wang, Xing Kang, Harri Alenius, Sunny Hei Wong, Piia Karisola & Hani El-Nezami. (2022) Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis. Food and Chemical Toxicology 169, pages 113368.
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Maria Grazia Ammendolia & Barbara De Berardis. (2022) Nanoparticle Impact on the Bacterial Adaptation: Focus on Nano-Titania. Nanomaterials 12:20, pages 3616.
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Dora Rolo, Ricardo Assunção, Célia Ventura, Paula Alvito, Lídia Gonçalves, Carla Martins, Ana Bettencourt, Peter Jordan, Nádia Vital, Joana Pereira, Fátima Pinto, Paulo Matos, Maria João Silva & Henriqueta Louro. (2022) Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials 12:19, pages 3275.
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Sara Gimondi, Rui L. Reis, Helena Ferreira & Nuno M. Neves. (2022) Microfluidic-driven mixing of high molecular weight polymeric complexes for precise nanoparticle downsizing. Nanomedicine: Nanotechnology, Biology and Medicine 43, pages 102560.
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Crossref
Anca Diana Racovita. (2022) Titanium Dioxide: Structure, Impact, and Toxicity. International Journal of Environmental Research and Public Health 19:9, pages 5681.
Crossref
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Crossref
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Crossref
Jefferson de Oliveira Mallia, Russell Galea, Rajat Nag, Enda Cummins, Ruben Gatt & Vasilis Valdramidis. (2022) Nanoparticle Food Applications and Their Toxicity: Current Trends and Needs in Risk Assessment Strategies. Journal of Food Protection 85:2, pages 355-372.
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Sara Gimondi, Carlos F. Guimarães, Sara F. Vieira, Virgínia M.F. Gonçalves, Maria E. Tiritan, Rui L. Reis, Helena Ferreira & Nuno M. Neves. (2022) Microfluidic mixing system for precise PLGA-PEG nanoparticles size control. Nanomedicine: Nanotechnology, Biology and Medicine 40, pages 102482.
Crossref
Adriana Vieira, Ana Gramacho, Dora Rolo, Nádia Vital, Maria João Silva & Henriqueta Louro. 2022. Nanotoxicology in Safety Assessment of Nanomaterials. Nanotoxicology in Safety Assessment of Nanomaterials 225 257 .
Shanji Liu, Yu Zhao, Yingxia Liu, Yizhou Tang, Xiaowei Xu, Mengqi Wang, Xueying Tao & Hengyi Xu. (2022) Pre-Exposure to TiO2-NPs Aggravates Alcohol-Related Liver Injury by Inducing Intestinal Barrier Damage in Mice. Toxicological Sciences 185:1, pages 28-37.
Crossref
Frédérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand & Marie Carriere. (2021) Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer. Particle and Fibre Toxicology 18:1.
Crossref
Luisana Di Cristo, Agnes G. Oomen, Susan Dekkers, Colin Moore, Walter Rocchia, Fiona Murphy, Helinor J. Johnston, Gemma Janer, Andrea Haase, Vicki Stone & Stefania Sabella. (2021) Grouping Hypotheses and an Integrated Approach to Testing and Assessment of Nanomaterials Following Oral Ingestion. Nanomaterials 11:10, pages 2623.
Crossref
Justyna Modrzynska, Alicja Mortensen, Trine Berthing, Gitte Ravn-Haren, Józef Szarek, Anne Thoustrup Saber & Ulla Vogel. (2021) Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously. Applied Nano 2:3, pages 222-241.
Crossref
Simon More, Vasileios Bampidis, Diane Benford, Claude Bragard, Thorhallur Halldorsson, Antonio Hernández‐Jerez, Susanne Hougaard Bennekou, Kostas Koutsoumanis, Claude Lambré, Kyriaki Machera, Hanspeter Naegeli, Søren Nielsen, Josef Schlatter, Dieter Schrenk, Vittorio Silano (deceased)Dominique Turck, Maged Younes, Jacqueline Castenmiller, Qasim Chaudhry, Francesco Cubadda, Roland Franz, David Gott, Jan Mast, Alicja Mortensen, Agnes G. Oomen, Stefan Weigel, Eric Barthelemy, Ana Rincon, Jose Tarazona & Reinhilde Schoonjans. (2021) Guidance on technical requirements for regulated food and feed product applications to establish the presence of small particles including nanoparticles. EFSA Journal 19:8.
Crossref
Laeticia Perez, Eleonora Scarcello, Saloua Ibouraadaten, Yousof Yakoub, Riccardo Leinardi, Jérôme Ambroise, Bertrand Bearzatto, Jean-Luc Gala, Adrien Paquot, Giulio G. Muccioli, Caroline Bouzin, Sybille van den Brule & Dominique Lison. (2021) Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure. Food and Chemical Toxicology 154, pages 112352.
Crossref
Sheeana Gangadoo, Huu Nguyen, Piumie Rajapaksha, Hala Zreiqat, Kay Latham, Daniel Cozzolino, James Chapman & Vi Khanh Truong. (2021) Inorganic nanoparticles as food additives and their influence on the human gut microbiota. Environmental Science: Nano 8:6, pages 1500-1518.
Crossref
Ninell P. Mortensen, Maria Moreno Caffaro, Shyam Aravamudhan, Lakshmi Beeravalli, Sharmista Prattipati, Rodney W. Snyder, Scott L. Watson, Purvi R. Patel, Frank X. Weber, Stephanie A. Montgomery, Susan J. Sumner & Timothy R. Fennell. (2021) Simulated Gastric Digestion and In Vivo Intestinal Uptake of Orally Administered CuO Nanoparticles and TiO2 E171 in Male and Female Rat Pups. Nanomaterials 11:6, pages 1487.
Crossref
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl‐Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Detlef Wölfle, Emanuela Corsini, Francesco Cubadda, Didima De Groot, Rex FitzGerald, Sara Gunnare, Arno Christian Gutleb, Jan Mast, Alicja Mortensen, Agnes Oomen, Aldert Piersma, Veronika Plichta, Beate Ulbrich, Henk Van Loveren, Diane Benford, Margherita Bignami, Claudia Bolognesi, Riccardo Crebelli, Maria Dusinska, Francesca Marcon, Elsa Nielsen, Josef Schlatter, Christiane Vleminckx, Stefania Barmaz, Maria Carfí, Consuelo Civitella, Alessandra Giarola, Ana Maria Rincon, Rositsa Serafimova, Camilla Smeraldi, Jose Tarazona, Alexandra Tard & Matthew Wright. (2021) Safety assessment of titanium dioxide (E171) as a food additive. EFSA Journal 19:5.
Crossref
Yu Zhao, Yizhou Tang, Shanji Liu, Tiantian Jia, Donggen Zhou & Hengyi Xu. (2021) Foodborne TiO2 Nanoparticles Induced More Severe Hepatotoxicity in Fructose-Induced Metabolic Syndrome Mice via Exacerbating Oxidative Stress-Mediated Intestinal Barrier Damage. Foods 10:5, pages 986.
Crossref
N. J. Tytgat. (2021) Meeting report of Gastro Update Europe 2020, September 4-5, 2020. Experimental and Clinical Gastroenterology:2, pages 120-134.
Crossref
Bin Li, Sew Lay Chua, Dingyi Yu, Sheot Harn Chan & Angela Li. (2021) Separation and size characterization of highly polydisperse titanium dioxide nanoparticles (E171) in powdered beverages by using Asymmetric Flow Field-Flow Fractionation hyphenated with Multi-Angle Light Scattering and Inductively Coupled Plasma Mass Spectrometry. Journal of Chromatography A 1643, pages 462059.
Crossref
Hualu Zhou, Jinning Liu, Taotao Dai, Jorge L. Muriel Mundo, Yunbing Tan, Long Bai & David Julian McClements. (2021) The gastrointestinal fate of inorganic and organic nanoparticles in vitamin D-fortified plant-based milks. Food Hydrocolloids 112, pages 106310.
Crossref
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Häfliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Bäbler, Kirstin Atrott, Silvia Lang & Michael Scharl. (2021) Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells. International Journal of Molecular Sciences 22:2, pages 772.
Crossref
Liyang Yao, Ling Chen, Bolu Chen, Yizhou Tang, Yu Zhao, Shanji Liu & Hengyi Xu. (2021) Toxic effects of TiO2 NPs in the blood-milk barrier of the maternal dams and growth of offspring. Ecotoxicology and Environmental Safety 208, pages 111762.
Crossref
Estefany I. Medina-Reyes, Carolina Rodríguez-Ibarra, Alejandro Déciga-Alcaraz, Daniel Díaz-Urbina, Yolanda I. Chirino & José Pedraza-Chaverri. (2020) Food additives containing nanoparticles induce gastrotoxicity, hepatotoxicity and alterations in animal behavior: The unknown role of oxidative stress. Food and Chemical Toxicology 146, pages 111814.
Crossref
Estefany I. Medina-Reyes, Norma L. Delgado-Buenrostro, Daniel Díaz-Urbina, Carolina Rodríguez-Ibarra, Alejandro Déciga-Alcaraz, Marisol I. González, José L. Reyes, Tomás E. Villamar-Duque, María LO. Flores-Sánchez, Rogelio Hernández-Pando, Juan M. Mancilla-Díaz, Yolanda I. Chirino & José Pedraza-Chaverri. (2020) Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat diet model. Food and Chemical Toxicology 146, pages 111786.
Crossref
Yu Zhao, Yizhou Tang, Ling Chen, Sidi Lv, Shanji Liu, Penghui Nie, Zoraida P. Aguilar & Hengyi Xu. (2020) Restraining the TiO2 nanoparticles-induced intestinal inflammation mediated by gut microbiota in juvenile rats via ingestion of Lactobacillus rhamnosus GG. Ecotoxicology and Environmental Safety 206, pages 111393.
Crossref
Zhangjian Chen, Pai Zheng, Shuo Han, Jiahe Zhang, Zejun Li, Shupei Zhou & Guang Jia. (2020) Tissue-specific oxidative stress and element distribution after oral exposure to titanium dioxide nanoparticles in rats. Nanoscale 12:38, pages 20033-20046.
Crossref
Zhangjian Chen, Shuo Han, Pai Zheng, Shupei Zhou & Guang Jia. (2020) Combined effect of titanium dioxide nanoparticles and glucose on the blood glucose homeostasis in young rats after oral administration. Journal of Applied Toxicology 40:9, pages 1284-1296.
Crossref
Zhangjian Chen, Shuo Han, Di Zhou, Pai Zheng, Shupei Zhou & Guang Jia. (2020) Serum metabolomic signatures of Sprague-Dawley rats after oral administration of titanium dioxide nanoparticles. NanoImpact 19, pages 100236.
Crossref
Joanna Musial, Rafal Krakowiak, Dariusz T. Mlynarczyk, Tomasz Goslinski & Beata J. Stanisz. (2020) Titanium Dioxide Nanoparticles in Food and Personal Care Products—What Do We Know about Their Safety?. Nanomaterials 10:6, pages 1110.
Crossref
Zhangjian Chen, Shuo Han, Shupei Zhou, Huimin Feng, Ying Liu & Guang Jia. (2020) Review of health safety aspects of titanium dioxide nanoparticles in food application. NanoImpact 18, pages 100224.
Crossref
Eveline Verleysen, Nadia Waegeneers, Frédéric Brassinne, Sandra De Vos, Isaac Ojea Jimenez, Stella Mathioudaki & Jan Mast. (2020) Physicochemical Characterization of the Pristine E171 Food Additive by Standardized and Validated Methods. Nanomaterials 10:3, pages 592.
Crossref
Zhangjian Chen, Shuo Han, Pai Zheng, Di Zhou, Shupei Zhou & Guang Jia. (2020) Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats. Nanoscale 12:10, pages 5973-5986.
Crossref

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