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Drug Discovery Case History

The preclinical discovery and development of brivaracetam for the treatment of focal epilepsy

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Pages 1169-1178 | Received 22 Jun 2017, Accepted 09 Aug 2017, Published online: 23 Aug 2017

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Eleonora Tulli, Giuseppe Di Cara, Giulia Iapadre, Pasquale Striano & Alberto Verrotti. (2021) An update on brivaracetam for the treatment of pediatric partial epilepsy. Expert Opinion on Pharmacotherapy 22:11, pages 1387-1395.
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Stefano de Biase, Gian Luigi Gigli & Mariarosaria Valente. (2020) Brivaracetam for the treatment of focal-onset seizures: pharmacokinetic and pharmacodynamic evaluations. Expert Opinion on Drug Metabolism & Toxicology 16:10, pages 853-863.
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Roberta Roberti, Caterina Palleria, Valentina Nesci, Martina Tallarico, Carlo Di Bonaventura, Emanuele Cerulli Irelli, Alessandra Morano, Giovambattista De Sarro, Emilio Russo & Rita Citraro. (2020) Pharmacokinetic considerations about antiseizure medications in the elderly. Expert Opinion on Drug Metabolism & Toxicology 16:10, pages 983-995.
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Alessandra Morano, Luigi Iannone, Caterina Palleria, Martina Fanella, Anna Teresa Giallonardo, Giovambattista De Sarro, Emilio Russo & Carlo Di Bonaventura. (2019) Pharmacology of new and developing intravenous therapies for the management of seizures and epilepsy. Expert Opinion on Pharmacotherapy 20:1, pages 25-39.
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Articles from other publishers (12)

Ting Song, Lingjun Feng, Yulei Xia, Meng Pang, Jianhong Geng, Xiaojun Zhang & Yanqiang Wang. (2023) Safety and efficacy of brivaracetam in children epilepsy: a systematic review and meta-analysis. Frontiers in Neurology 14.
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Federico M Garofalo, María L Sbaraglini, Emilia M Barrionuevo, Estefanía Peralta, Evelyn L Bonifazi, Alan Talevi & Luciana Gavernet. (2023) Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid. Future Medicinal Chemistry 15:9, pages 735-743.
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Kuan‐Ying Li, Chung‐Yao Hsu & Yuan‐Han Yang. (2023) A review of cognitive and behavioral outcomes of Brivaracetam. The Kaohsiung Journal of Medical Sciences 39:2, pages 104-114.
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Sophie Naddell, Megan Manuel, Rebecca Cavill, Paul White & Katarzyna Sieradzan. (2023) BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam. Epilepsy & Behavior 138, pages 108985.
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Clifford L. Eastman, Jason S. Fender, Pavel Klein & Raimondo D’Ambrosio. (2021) Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat. Journal of Pharmacology and Experimental Therapeutics 379:3, pages 310-323.
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Mukund Jha, Ozair Alam, Mohd. Javed Naim, Vrinda Sharma, Parth Bhatia, Aadil Ahmad Sheikh, Farah Nawaz, Perwaiz Alam, Ajay Manaithiya, Vivek Kumar, Shagufi Nazar & Nadeem Siddiqui. (2020) Recent advancement in the discovery and development of anti-epileptic biomolecules: An insight into structure activity relationship and Docking. European Journal of Pharmaceutical Sciences 153, pages 105494.
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Sara McGuire, Gustavo Silva, Darshan Lal, Divya S. KhuranaAgustin Legido, Daphne Hasbani, Karen S. Carvalho, Joseph Melvin & Ignacio Valencia. (2019) Safety and Efficacy of Brivaracetam in Pediatric Refractory Epilepsy: A Single-Center Clinical Experience. Journal of Child Neurology 35:2, pages 102-105.
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Joel M Oster. (2019) Brivaracetam: a newly approved medication for epilepsy. Future Neurology 14:3, pages FNL23.
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Solomiya Tsymbalyuk, Madeleine Smith, Charles Gore, Orest Tsymbalyuk, Svetlana Ivanova, Charles Sansur, Volodymyr Gerzanich & J Marc Simard. (2019) Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain. Molecular Pain 15, pages 174480691988650.
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Evangelia Theochari, Hannah Cock, Dora Lozsadi, Clare Galtrey, Jan Arevalo & Marco Mula. (2019) Brivaracetam in adults with drug-resistant epilepsy and psychiatric comorbidities. Epilepsy & Behavior 90, pages 129-131.
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Brian Raymer & Samit K. Bhattacharya. (2018) Lead-like Drugs: A Perspective. Journal of Medicinal Chemistry 61:23, pages 10375-10384.
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Qingting Hu, Fang Zhang, Wenhui Teng, Fangfang Hao, Jing Zhang, Mingxiao Yin & Naidong Wang. (2017) Efficacy and safety of antiepileptic drugs for refractory partial-onset epilepsy: a network meta-analysis. Journal of Neurology 265:1, pages 1-11.
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