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Expert Opinion on Drug Discovery Volume 14, 2019 - Issue 4
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Review

Animal models of major depressive disorder and the implications for drug discovery and development

Konstantin A. DeminInstitute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia;Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, RussiaView further author information
,
Maxim SysoevLaboratory of Preclinical Bioscreening, Russian Research Center for Radiology and Surgical Technologies, St. Petersburg, Russia;Institute of Experimental Medicine, St. Petersburg, RussiaView further author information
,
Maria V. ChernyshInstitute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, RussiaView further author information
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Anna K. SavvaFaculty of Biology, St. Petersburg State University, St. Petersburg, RussiaView further author information
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Mamiko KoshibaYamaguchi University, Yamaguchi, JapanView further author information
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Edina A. Wappler-GuzzettaThe International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USAView further author information
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Cai SongResearch Institute of Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China;Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, ChinaView further author information
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Murilo S. De AbreuBioscience Institute, University of Passo Fundo (UPF), Passo Fundo, BrazilView further author information
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Brian LeonardNational University of Ireland, Galway, IrelandView further author information
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Matthew O. ParkerBrain and Behaviour Lab, School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UKView further author information
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Brian H. HarveyCenter of Excellence for Pharmaceutical Sciences, Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South AfricaView further author information
,
Li TianInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaView further author information
,
Eero VasarInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaView further author information
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Tatyana StrekalovaLaboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, and Department of Normal Physiology, Sechenov First Moscow State Medical University, Moscow, Russia;Laboratory of Cognitive Dysfunctions, Institute of General Pathology and Pathophysiology, Moscow, Russia;Department of Neuroscience, Maastricht University, Maastricht, The NetherlandsView further author information
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Tamara G. AmstislavskayaScientific Research Institute of Physiology and Basic Medicine, Novosibirsk, RussiaView further author information
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Andrey D. VolginThe International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA;Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, RussiaView further author information
,
Erik T. AlpyshovSchool of Pharmacy, Southwest University, Chongqing, ChinaView further author information
,
Dongmei WangSchool of Pharmacy, Southwest University, Chongqing, ChinaView further author information
&
Allan V. KalueffSchool of Pharmacy, Southwest University, Chongqing, China;Almazov National Medical Research Centre, St. Petersburg, Russia;Ural Federal University, Ekaterinburg, Russia;Granov Russian Research Center of Radiology and Surgical Technologies, St. Petersburg, Russia;Laboratory of Biological Psychiatry, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia;Laboratory of Translational Biopsychiatry, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia;ZENEREI Institute, Slidell, LA, USA;The International Stress and Behavior Society (ISBS), US HQ, New Orleans, LA, USACorrespondence[email protected]
View further author information
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Pages 365-378 | Received 14 Nov 2018, Accepted 24 Jan 2019, Published online: 22 Feb 2019

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Jiajia Duan & Peng Xie. (2020) The potential for metabolomics in the study and treatment of major depressive disorder and related conditions. Expert Review of Proteomics 17:4, pages 309-322.
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Crystal Lubbe, Leith C. R. Meyer, Tertius A. Kohn, Brian H. Harvey & De Wet Wolmarans. (2022) The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy. Veterinary Research Communications 47:2, pages 361-371.
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Daniel Aaron Vazquez-Matias, Erik F. J. de Vries, Rudi A. J. O. Dierckx & Janine Doorduin. (2023) PET imaging of animal models with depressive-like phenotypes. European Journal of Nuclear Medicine and Molecular Imaging 50:6, pages 1564-1584.
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Lauren Granata, Abigail Parakoyi & Heather C. Brenhouse. (2022) Age- and sex-specific effects of maternal separation on the acoustic startle reflex in rats: early baseline enhancement in females and blunted response to ambiguous threat. Frontiers in Behavioral Neuroscience 16.
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Tatyana Strekalova, Yanzhi Liu, Daniel Kiselev, Sharafuddin Khairuddin, Jennifer Lok Yu Chiu, Justin Lam, Ying-Shing Chan, Dmitrii Pavlov, Andrey Proshin, Klaus-Peter Lesch, Daniel C. Anthony & Lee Wei Lim. (2022) Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives. Psychopharmacology 239:3, pages 663-693.
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Tatyana Strekalova, Dmitrii Pavlov, Alexander Trofimov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch & Raymond Cespuglio. (2022) Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice. International Journal of Molecular Sciences 23:4, pages 2061.
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Michel Bourin. 2022. Translational Research Methods for Major Depressive Disorder. Translational Research Methods for Major Depressive Disorder 57 84 .
Paul J. Fitzgerald. (2021) Are Noradrenergic Transmission Reducing Drugs Antidepressants?. Frontiers in Behavioral Neuroscience 15.
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Julie Lasselin, Mats Lekander, Sven Benson, Manfred Schedlowski & Harald Engler. (2020) Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression. Molecular Psychiatry 26:8, pages 3672-3683.
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Murilo S. Abreu, Caio Maximino, Filipe Banha, Pedro M. Anastácio, Konstantin A. Demin, Allan V. Kalueff & Marta C. Soares. (2019) Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish. Journal of Neuroscience Research 98:5, pages 764-779.
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K. Mncube, M. Möller-Wolmarans & B.H. Harvey. (2019) P.725 Exploring a gene-x-environment model of treatment resistant depression: behavioural studies and response to fluoxetine treatment. European Neuropsychopharmacology 29, pages S488-S489.
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Fatma Mena & Labonté Benoit. (2019) Molecular programs underlying differences in the expression of mood disorders in males and females. Brain Research 1719, pages 89-103.
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