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Expert Opinion on Drug Discovery Volume 15, 2020 - Issue 1
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Drug Discovery Case History

Lenvatinib for thyroid cancer treatment: discovery, pre-clinical development and clinical application

Rosa Maria ParagliolaEndocrinology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS – Università Cattolica del Sacro Cuore, Rome, ItalyCorrespondence[email protected]
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,
Andrea CorselloEndocrinology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS – Università Cattolica del Sacro Cuore, Rome, ItalyView further author information
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Valeria Del GattoEndocrinology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS – Università Cattolica del Sacro Cuore, Rome, ItalyView further author information
,
Giampaolo PapiEndocrinology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS – Università Cattolica del Sacro Cuore, Rome, ItalyView further author information
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Alfredo PontecorviEndocrinology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS – Università Cattolica del Sacro Cuore, Rome, ItalyView further author information
&
Salvatore Maria CorselloEndocrinology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS – Università Cattolica del Sacro Cuore, Rome, ItalyView further author information
Pages 11-26 | Received 06 Jun 2019, Accepted 26 Sep 2019, Published online: 13 Oct 2019

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Siddharth J. Modi & Vithal M. Kulkarni. (2022) Exploration of structural requirements for the inhibition of VEGFR-2 tyrosine kinase: Binding site analysis of type II, ‘DFG-out’ inhibitors. Journal of Biomolecular Structure and Dynamics 40:12, pages 5712-5727.
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Pietro Locantore, Roberto Novizio, Andrea Corsello, Rosa Maria Paragliola, Alfredo Pontecorvi & Salvatore Maria Corsello. (2022) Discovery, preclinical development, and clinical application of pralsetinib in the treatment of thyroid cancer. Expert Opinion on Drug Discovery 17:2, pages 101-107.
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Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Valeria Mazzi, Mario Miccoli, Maria Rosaria Galdiero, Gilda Varricchi, Rudy Foddis, Giovanni Guglielmi, Claudio Spinelli, Concettina La Motta, Salvatore Benvenga, Alessandro Antonelli & Poupak Fallahi. (2021) Lenvatinib: an investigational agent for the treatment of differentiated thyroid cancer. Expert Opinion on Investigational Drugs 30:9, pages 913-921.
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Articles from other publishers (3)

Sushanta Bhattacharya, Vivek Asati, Amena Ali, Abuzer Ali & G.D. Gupta. (2022) In-silico studies for the development of novel RET inhibitors for cancer treatment. Journal of Molecular Structure 1251, pages 132040.
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Naga Rajiv Lakkaniga, Naresh Gunaganti, Lingtian Zhang, Binyam Belachew, Brendan Frett, Yuet-Kin Leung & Hong-yu Li. (2020) Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 206, pages 112691.
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Mohammad Al-Jundi, Shilpa Thakur, Sriram Gubbi & Joanna Klubo-Gwiezdzinska. (2020) Novel Targeted Therapies for Metastatic Thyroid Cancer—A Comprehensive Review. Cancers 12:8, pages 2104.
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