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Expert Opinion on Drug Discovery Volume 15, 2020 - Issue 2
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Review

Current discovery strategies for hepatocellular carcinoma therapeutics

Qiuzi DaiDepartment of Chemistry, Tsinghua University, Beijing, PR China;National & Local United Engineering Lab for Personalized Anti-tumor Drugs, The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR China;Shenzhen Bay Laboratory, Shenzhen, PR ChinaView further author information
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Cunlong ZhangShenzhen Bay Laboratory, Shenzhen, PR China;National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR ChinaView further author information
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Zigao YuanNational & Local United Engineering Lab for Personalized Anti-tumor Drugs, The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR China;Shenzhen Bay Laboratory, Shenzhen, PR China;National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR ChinaView further author information
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Qinsheng SunNational & Local United Engineering Lab for Personalized Anti-tumor Drugs, The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR China;Shenzhen Bay Laboratory, Shenzhen, PR China;National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR ChinaCorrespondence[email protected]
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&
Yuyang JiangNational & Local United Engineering Lab for Personalized Anti-tumor Drugs, The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, PR China;Shenzhen Bay Laboratory, Shenzhen, PR China;Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. ChinaCorrespondence[email protected]
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Pages 243-258 | Received 29 Jul 2019, Accepted 20 Nov 2019, Published online: 06 Dec 2019

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Rensong Sun, Linlin Fang, Xia Lv, Jiani Fang, Yuting Wang, Dapeng Chen, Liang Wang, Jun Chen, Yan Qi, Zeyao Tang, Jianbin Zhang & Yan Tian. (2021) In vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein receptor. Drug Delivery 28:1, pages 2071-2084.
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Articles from other publishers (13)

Jingtao Chen, Chao Niu, Ning Yang, Chunyan Liu, Shan-shan Zou & Shan Zhu. (2023) Biomarker discovery and application—An opportunity to resolve the challenge of liver cancer diagnosis and treatment. Pharmacological Research 189, pages 106674.
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Yuan Wang, Yun-Bao Ma, Xiao-Yan Huang, Tian-Ze Li, Xiao-Feng He, Xue-Mei Zhang & Ji-Jun Chen. (2023) Artemleucolides A−L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity. Fitoterapia 165, pages 105399.
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Haoyi Han, Ali Mohammed Mohammed Alsayed, Yi Wang, Qi Yan, Ancheng Shen, Jianxia Zhang, Yanfei Ye, Zhiguo Liu, Kun Wang & Xiaohui Zheng. (2023) Discovery of β-cyclocitral-derived mono-carbonyl curcumin analogs as anti-hepatocellular carcinoma agents via suppression of MAPK signaling pathway. Bioorganic Chemistry 132, pages 106358.
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Ruyin Chen, Qiong Li, Shuaishuai Xu, Chanqi Ye, Tian Tian, Qi Jiang, Jianzhen Shan & Jian Ruan. (2022) Modulation of the tumour microenvironment in hepatocellular carcinoma by tyrosine kinase inhibitors: from modulation to combination therapy targeting the microenvironment. Cancer Cell International 22:1.
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Xin Zhang, Yun-Bao Ma, Xiao-Feng He, Tian-Ze Li, Chang-An Geng, Li-Hua Su, Shuang Tang, Zhen Gao & Ji-Jun Chen. (2022) Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha. Natural Products and Bioprospecting 12:1.
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Zhenxiong Gao, Tingting Fan, Linbo Chen, Mengchu Yang, Vincent Kam Wai Wong, Dawei Chen, Zijian Liu, Yaoyao Zhou, Weibin Wu, Zixuan Qiu, Cunlong Zhang, Yuan Li & Yuyang Jiang. (2022) Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein. European Journal of Medicinal Chemistry 238, pages 114402.
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Hyun Jin Park, Garam Choi, Seongmin Ha, Yesl Kim, Min-Jin Choi, Minsup Kim, Md. Kamrul Islam, Yongmin Chang, Tae-Jun Kwon, Dongkyu Kim, Eunbee Jang, Tae Hwan Kim, Sha Joung Chang & Yeoun-Hee Kim. (2022) MBP-11901 Inhibits Tumor Growth of Hepatocellular Carcinoma through Multitargeted Inhibition of Receptor Tyrosine Kinases. Cancers 14:8, pages 1994.
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Li-Hua Su, Yun-Bao Ma, Chang-An Geng, Tian-Ze Li, Xiao-Yan Huang, Jing Hu, Xin Zhang, Shuang Tang, Cheng Shen, Zhen Gao, Xue-Mei Zhang & Ji-Jun Chen. (2021) Artematrovirenins A–P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens. Bioorganic Chemistry 114, pages 105072.
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Michael J. Nutt, Yeung Sing Yee, Amanda Buyan, Neil Andrewartha, Ben Corry, George C.T. Yeoh & Scott G. Stewart. (2021) In pursuit of a selective hepatocellular carcinoma therapeutic agent: Novel thalidomide derivatives with antiproliferative, antimigratory and STAT3 inhibitory properties. European Journal of Medicinal Chemistry 217, pages 113353.
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Teresa Garcia-Lezana, Juan Luis Lopez-Canovas & Augusto Villanueva. 2021. Mechanisms and Therapy of Liver Cancer. Mechanisms and Therapy of Liver Cancer 63 101 .
Diren Beyoğlu & Jeffrey R. Idle. (2020) Metabolomic insights into the mode of action of natural products in the treatment of liver disease. Biochemical Pharmacology 180, pages 114171.
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Shuang Tang, Xin-Tian Zhang, Yun-Bao Ma, Xiao-Yan Huang, Chang-An Geng, Tian-Ze Li, Xue-Mei Zhang, Cheng Shen, Li-Hua Su, Zhen Gao & Ji-Jun Chen. (2020) Artemyrianolides A–S, Cytotoxic Sesquiterpenoids from Artemisia myriantha . Journal of Natural Products 83:9, pages 2618-2630.
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Shuang Tang, Yun-Bao Ma, Chang-An Geng, Cheng Shen, Tian-Ze Li, Xue-Mei Zhang, Li-Hua Su, Zhen Gao, Jing Hu & Ji-Jun Chen. (2020) Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells. Natural Products and Bioprospecting 10:4, pages 251-260.
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