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Review

An update on the importance of plasma protein binding in drug discovery and development

Pages 1453-1465 | Received 28 May 2021, Accepted 26 Jul 2021, Published online: 17 Aug 2021

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Julia Annette Schulz, David M. Stresser & John Cory Kalvass. (2023) Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review. Drug Metabolism Reviews 55:3, pages 205-238.
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Siennah R. Greenfield, Heather Eng, Qingyi Yang, Chunyang Guo, Laura Byrnes, Alyssa Dantonio, Graham West, Li Di & Amit S. Kalgutkar. (2023) Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir. Xenobiotica 53:1, pages 12-24.
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I Sartini, B Łebkowska-Wieruszewska, M Krupa, A Lisowski, A Poapolathep & M Giorgi. (2022) Pharmacokinetics of ivermectin after oral and intravenous administration in Biłgorajska geese (Anser anser domesticus). New Zealand Veterinary Journal 70:6, pages 313-318.
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Dunja Dimitrijevic, Eric Fabian, Dorothee Funk-Weyer & Robert Landsiedel. (2023) Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma. Biochemical and Biophysical Research Communications 651, pages 114-120.
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Jia Liu, Furun Wang, Xi Wang, Shiyong Fan, Yufeng Li, Mingyue Xu, Hengrui Hu, Ke Liu, Bohong Zheng, Lingchao Wang, Huanyu Zhang, Jiang Li, Wei Li, Wenpeng Zhang, Zhihong Hu, Ruiyuan Cao, Xiaomei Zhuang, Manli Wang & Wu Zhong. (2023) Antiviral effects and tissue exposure of tetrandrine against SARS‐CoV‐2 infection and COVID‐19. MedComm 4:1.
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Li Di. (2022) Special issue on applications of in vitro, in vivo, and modeling and simulation tools for central nervous system drug disposition. Biopharmaceutics & Drug Disposition 44:1, pages 3-6.
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Sangwoo Ryu, David Tess & Li Di. (2022) Addressing the Accuracy of Plasma Protein Binding Measurement for Highly Bound Compounds Using the Dilution Method. The AAPS Journal 25:1.
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Neil Parrott, Nenad Manevski & Andrés Olivares-Morales. (2022) Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds. Molecular Pharmaceutics 19:11, pages 3858-3868.
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Jianwei Fan, Katherine Gilmartin, Steven Octaviano, Francisca Villar, Brianna Remache & John Regan. (2022) Using Human Serum Albumin Binding Affinities as a Proactive Strategy to Affect the Pharmacodynamics and Pharmacokinetics of Preclinical Drug Candidates. ACS Pharmacology & Translational Science 5:9, pages 803-810.
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Hifza Ahmed, Felix Bergmann & Markus Zeitlinger. (2022) Protein Binding in Translational Antimicrobial Development-Focus on Interspecies Differences. Antibiotics 11:7, pages 923.
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Mohammad Hassan Baig, Preeti Gupta, Mohd. Imran Khan, Mohamed F. Alajmi, Afzal Hussain, Md. Imtaiyaz Hassan & Jae-June Dong. (2022) Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches . Current Topics in Medicinal Chemistry 22:10, pages 879-890.
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Tony Cardoso, Ana Sofia Almeida, Fernando Remião & Carla Fernandes. (2021) Enantioresolution and Binding Affinity Studies on Human Serum Albumin: Recent Applications and Trends. Chemosensors 9:11, pages 304.
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