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Expert Review of Clinical Pharmacology Volume 10, 2017 - Issue 2
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Review

Mood Therapeutics: Novel Pharmacological Approaches for Treating Depression

Ioline D. HenterExperimental Therapeutics and Pathophysiology Branch, NIMH-NIH, Bethesda, Maryland, USAView further author information
,
Rafael T. de SousaExperimental Therapeutics and Pathophysiology Branch, NIMH-NIH, Bethesda, Maryland, USAView further author information
,
Philip W. GoldExperimental Therapeutics and Pathophysiology Branch, NIMH-NIH, Bethesda, Maryland, USAView further author information
,
Andre R. BrunoniLaboratory of Neuroscience, LIM- 27, Institute and Department of Psychiatry, University of São Paulo, São Paulo, BrazilView further author information
,
Carlos A. Zarate JrExperimental Therapeutics and Pathophysiology Branch, NIMH-NIH, Bethesda, Maryland, USAView further author information
&
Rodrigo Machado-VieiraExperimental Therapeutics and Pathophysiology Branch, NIMH-NIH, Bethesda, Maryland, USACorrespondence[email protected]
View further author information
Pages 153-166 | Received 06 Sep 2016, Accepted 24 Oct 2016, Published online: 16 Jan 2017

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Cynthia V. Calkin. (2019) Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder. Annals of Medicine 51:5-6, pages 281-293.
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Eva Ceskova & Petr Silhan. (2018) Novel treatment options in depression and psychosis. Neuropsychiatric Disease and Treatment 14, pages 741-747.
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Agata Zięba, Dariusz Matosiuk & Agnieszka A. Kaczor. (2023) The Role of Genetics in the Development and Pharmacotherapy of Depression and Its Impact on Drug Discovery. International Journal of Molecular Sciences 24:3, pages 2946.
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Anna Carotenuto, Angiola Maria Fasanaro, Valentino Manzo, Francesco Amenta & Enea Traini. (2022) Association Between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in the Treatment of Depression in Patients with Alzheimer’s Disease. Journal of Alzheimer's Disease Reports 6:1, pages 235-243.
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Sheng Wang, Guilan Huang, Jie Yan, Changxi Li, Jianwen Feng, Qi Chen, Xiaomeng Zheng, Haobin Li, Jiangchao Li, Lijing Wang & Huimin Li. (2021) Influence of aging on chronic unpredictable mild stress-induced depression-like behavior in male C57BL/6J mice. Behavioural Brain Research 414, pages 113486.
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Rachel E. Teneralli, David M. Kern, M. Soledad Cepeda, James P. Gilbert & Wayne C. Drevets. (2021) Exploring real-world evidence to uncover unknown drug benefits and support the discovery of new treatment targets for depressive and bipolar disorders. Journal of Affective Disorders 290, pages 324-333.
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Ulderico Freo, Viola Brugnatelli, Fabio Turco & Gastone Zanette. (2021) Analgesic and Antidepressant Effects of the Clinical Glutamate Modulators Acetyl-L-Carnitine and Ketamine. Frontiers in Neuroscience 15.
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Concetta Crisafulli, Marco Calabrò, Laura Mandelli, Sheng-Min Wang, Soo-Jung Lee, Changsu Han, Ashwin Patkar, Prakash Masand, Chi-Un Pae, Daniel Souery, Julien Mendlewicz & Alessandro Serretti. (2021) Possible Modulatory Role of ARC Gene Variants in Mood Disorders. Clinical Psychopharmacology and Neuroscience 19:1, pages 46-52.
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Elnaz Roohi, Nematollah Jaafari & Farshad Hashemian. (2021) On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?. Journal of Neuroinflammation 18:1.
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Guang Chen, Rodrigo Machado-Vieira, Carlos A. Zarate & Husseini K. Manji. 2021. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1004 1010 .
Guang Chen, Rodrigo Machado-Vieira, Carlos A. Zarate & Husseini K. Manji. 2020. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1 7 .
I. A. Novakov, D. S. Sheikin, M. B. Navrotskii, A. S. Mkrtchyan, L. L. Brunilina & K. V. Balakin. (2020) Dexoxadrol and its bioisosteres: structure, synthesis, and pharmacological activity. Russian Chemical Bulletin 69:9, pages 1625-1671.
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Maryam Ardalan, Betina Elfving, Ali H. Rafati, Monireh Mansouri, Carlos A. ZarateJrJr, Aleksander A. Mathe & Gregers Wegener. (2020) Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner. European Neuropsychopharmacology 32, pages 94-103.
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Michele Tufano & Graziano Pinna. (2020) Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?. Molecules 25:5, pages 1062.
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M.C. Flux & Christopher A. Lowry. (2020) Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience. Neurobiology of Disease 135, pages 104578.
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Suélen Osório Heck, Vanessa Angonesi Zborowski, Simone Pinton & Cristina Wayne Nogueira. (2019) Pro-apoptotic cell signaling in the prefrontal cortex contributes to depressive-/anxiogenic-like behavioral phenotype of mice subchronically exposed to dexamethasone. Journal of Chemical Neuroanatomy 100, pages 101663.
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Svitlana Antoniuk, Monika Bijata, Evgeni Ponimaskin & Jakub Wlodarczyk. (2019) Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neuroscience & Biobehavioral Reviews 99, pages 101-116.
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Max A. Lazar & Roger S. McIntyre. 2019. Neurobiology of Depression. Neurobiology of Depression 383 400 .
Shivani Jaiswal, Rati Kailash Prasad Tripathi & Senthil Raja Ayyannan. (2018) Scaffold hopping-guided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors: Synthesis and evaluation. Biomedicine & Pharmacotherapy 107, pages 1611-1623.
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Tongtong Ge, Jie Fan, Wei Yang, Ranji Cui & Bingjin Li. (2018) Leptin in depression: a potential therapeutic target. Cell Death & Disease 9:11.
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F. Caraci, F. Calabrese, R. Molteni, L. Bartova, M. Dold, G. M. Leggio, C. Fabbri, J. Mendlewicz, G. Racagni, S. Kasper, M. A. Riva & F. Drago. (2018) International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets. Pharmacological Reviews 70:3, pages 475-504.
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Chong Gao, Xingmiao Chen, Aimin Xu, Kenneth Cheng & Jiangang Shen. (2017) Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. Molecular Neurobiology 55:7, pages 5537-5547.
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Gaurav Bedse, Rebecca J. Bluett, Toni A. Patrick, Nicole K. Romness, Andrew D. Gaulden, Philip J. Kingsley, Niels Plath, Lawrence J. Marnett & Sachin Patel. (2018) Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors. Translational Psychiatry 8:1.
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Caren J. Blacker, Charles P. Lewis, Mark A. Frye & Marin Veldic. (2017) Metabotropic glutamate receptors as emerging research targets in bipolar disorder. Psychiatry Research 257, pages 327-337.
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