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Expert Review of Clinical Pharmacology Volume 14, 2021 - Issue 4
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Review

Activation of Nrf2 signaling pathway by natural and synthetic chalcones: a therapeutic road map for oxidative stress

Melford Chuka Egbujora Department of Industrial Chemistry, Renaissance University, Ugbawka, Enugu State, NigeriaView further author information
,
Sarmistha Sahab Department of Cardiovascular and Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, Rome, ItalyCorrespondence[email protected]
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,
Brigitta Buttarib Department of Cardiovascular and Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-0575-4106View further author information
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Elisabetta Profumob Department of Cardiovascular and Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-7261-8884View further author information
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Luciano Sasoc Department of Physiology and Pharmacology “Vittorio Erspamer, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-4530-8706View further author information
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Pages 465-480 | Received 08 Jan 2021, Accepted 08 Mar 2021, Published online: 30 Mar 2021

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Bin Guo, Fang Chou, Libin Huang, Feifan Yin, Jing Fang, Jian-Bo Wang & Zongchao Jia. (2022) Recent insights into oxidative metabolism of quercetin: catabolic profiles, degradation pathways, catalyzing metalloenzymes and molecular mechanisms. Critical Reviews in Food Science and Nutrition 0:0, pages 1-28.
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Articles from other publishers (22)

Junjie Li, Rui Zhao, Peiran Miao, Fengfeng Xu, Jiahao Chen, Xiaoying Jiang, Zi Hui, Liwei Wang & Renren Bai. (2023) Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery. European Journal of Medicinal Chemistry 260, pages 115791.
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Karamjeet Kaur, R.K. Narang & Shamsher Singh. (2023) Glabridin mitigates TiO2NP induced cognitive deficit in adult zebrafish. Neurochemistry International 169, pages 105585.
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Marialucia GalloriniSimone Carradori, Emiliano Panieri, Matej SovaLuciano Saso. (2023) Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications. Antioxidants & Redox Signaling.
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Fernando Ferreira Leite, Natália Ferreira de Sousa, Bruno Hanrry Melo de Oliveira, Gabrielly Diniz Duarte, Maria Denise Leite Ferreira, Marcus Tullius Scotti, José Maria Barbosa Filho, Luís Cezar Rodrigues, Ricardo Olímpio de Moura, Francisco Jaime Bezerra Mendonça-Junior & Luciana Scotti. (2023) Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies. Molecules 28:10, pages 4009.
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Cai-Yu Lian, Bing-Xin Chu, Wei-Hao Xia, Zhen-Yong Wang, Rui-Feng Fan & Lin Wang. (2023) Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy. Journal of Advanced Research 46, pages 87-100.
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Melford C. Egbujor, Paolo Tucci, Ugomma C. Onyeije, Chigbundu N. Emeruwa & Luciano Saso. (2023) NRF2 Activation by Nitrogen Heterocycles: A Review. Molecules 28:6, pages 2751.
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Waseem Chauhan & Rahima Zennadi. (2023) Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell Disease. Antioxidants 12:3, pages 740.
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Melford Chuka Egbujor, Jorge Garrido, Fernanda Borges & Luciano Saso. (2023) Sulfonamide a Valid Scaffold for Antioxidant Drug Development. Mini-Reviews in Organic Chemistry 20:2, pages 190-209.
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Katarzyna Papierska, Violetta Krajka-Kuźniak, Robert Kleszcz, Tomasz Stefański, Rafał Kurczab & Maciej Kubicki. (2022) The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells. Scientific Reports 12:1.
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Innocent U. Okagu, Timothy P. C. Ezeorba, Rita N. Aguchem, Ikenna C. Ohanenye, Emmanuel C. Aham, Sunday N. Okafor, Carlotta Bollati & Carmen Lammi. (2022) A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases. International Journal of Molecular Sciences 23:15, pages 8468.
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Melford Chuka Egbujor, Brigitta Buttari, Elisabetta Profumo, Pelin Telkoparan-Akillilar & Luciano Saso. (2022) An Overview of NRF2-Activating Compounds Bearing α,β-Unsaturated Moiety and Their Antioxidant Effects. International Journal of Molecular Sciences 23:15, pages 8466.
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Melford Chuka Egbujor, Maria Petrosino, Karim Zuhra & Luciano Saso. (2022) The Role of Organosulfur Compounds as Nrf2 Activators and Their Antioxidant Effects. Antioxidants 11:7, pages 1255.
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Chun‐xiao Li, Jing‐chun Li, Jiang Lai & Ying Liu. (2022) The pharmacological and pharmacokinetic properties of esculin: A comprehensive review. Phytotherapy Research 36:6, pages 2434-2448.
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Sibel Suzen, Paolo Tucci, Elisabetta Profumo, Brigitta Buttari & Luciano Saso. (2022) A Pivotal Role of Nrf2 in Neurodegenerative Disorders: A New Way for Therapeutic Strategies. Pharmaceuticals 15:6, pages 692.
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Cheryl E. Rockwell, Yining Jin, Allison P. Boss, Luca M. Kaiser & Saamera Awali. (2022) The Complicated Role of Nuclear Factor Erythroid-Derived 2-Like 2 in Allergy and Asthma. Drug Metabolism and Disposition 50:4, pages 500-507.
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Mandeep Kaur & Raj Kaushal. (2022) Synthesis and in-silico molecular modelling, DFT studies, antiradical and antihyperglycemic activity of novel vanadyl complexes based on chalcone derivatives. Journal of Molecular Structure 1252, pages 132176.
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Huijie Chen, Jianqing Chen, Xu Shi, Lu Li & Shiwen Xu. (2021) Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway. BioFactors 48:1, pages 190-203.
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Muthu Thiruvengadam, Baskar Venkidasamy, Umadevi Subramanian, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Shabari Girish, Sivakumar Thangavel, Anand Raj Dhanapal, Natalya Fedoseeva, Joohyun Lee & Ill-Min Chung. (2021) Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation. Antioxidants 10:12, pages 1859.
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Juan A. Parga, Ana I. Rodriguez-Perez, Maria Garcia-Garrote, Jannette Rodriguez-Pallares & Jose L. Labandeira-Garcia. (2021) NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin. Antioxidants 10:11, pages 1649.
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Innocent U. Okagu, Joseph C. Ndefo, Emmanuel C. Aham, Joy I. Obeme-Nmom, Precious E. Agboinghale, Rita N. Aguchem, Regina N. Nechi & Carmen Lammi. (2021) Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits. Nutrients 13:9, pages 3266.
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Wengkun Li, BingMin Wu, Yange Wang, Ying Lin, Lin An & Guifang Zhang. (2021) The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus. BioMed Research International 2021, pages 1-9.
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Hiba A. Jasim, Lutfun Nahar, Mohammad A. Jasim, Sharon A. Moore, Kenneth J. Ritchie & Satyajit D. Sarker. (2021) Chalcones: Synthetic Chemistry Follows Where Nature Leads. Biomolecules 11:8, pages 1203.
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