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Channels Volume 12, 2018 - Issue 1
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Research Paper

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

Liberty François-MoutalDepartments of Pharmacology College of Medicine, University of Arizona, Tucson, ArizonaUSAORCID Iconhttp://orcid.org/0000-0003-1277-660XView further author information
ORCID Icon,
David Donald ScottDepartments of Pharmacology College of Medicine, University of Arizona, Tucson, ArizonaUSAView further author information
,
Samantha Perez-MillerDepartments of Pharmacology College of Medicine, University of Arizona, Tucson, ArizonaUSAView further author information
,
Vijay GokhaleDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZView further author information
,
May KhannaDepartments of Pharmacology College of Medicine, University of Arizona, Tucson, ArizonaUSA;Neuroscience Graduate Interdisciplinary Program, College of Medicine, University of Arizona, Tucson, ArizonaUSA;The Center for Innovation in Brain Sciences, The University of Arizona Health Sciences, Tucson, AZ, USAORCID Iconhttp://orcid.org/0000-0002-9989-6374View further author information
ORCID Icon &
Rajesh KhannaDepartments of Pharmacology College of Medicine, University of Arizona, Tucson, ArizonaUSA;Neuroscience Graduate Interdisciplinary Program, College of Medicine, University of Arizona, Tucson, ArizonaUSA;The Center for Innovation in Brain Sciences, The University of Arizona Health Sciences, Tucson, AZ, USACorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-9066-2969View further author information
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Pages 219-227 | Received 31 May 2018, Accepted 06 Jun 2018, Published online: 06 Aug 2018

Citations (13)

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Read on this site (2)

Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace & Rajesh Khanna. (2022) Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats. Channels 16:1, pages 1-8.
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L-A. R. Jansen, L. A. Forster, X. L. Smith, M. Rubaharan, A. Z. Murphy & D. J. Baro. (2021) Changes in peripheral HCN2 channels during persistent inflammation. Channels 15:1, pages 164-178.
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Articles from other publishers (11)

Jin-Young Yoon, Alexander M. Greiner, Julia S. Jacobs, Young-Rae Kim, Tyler P. Rasmussen, William J. Kutschke, Daniel S. Matasic, Ajit Vikram, Ravinder R. Gaddam, Haider Mehdi, Kaikobad Irani & Barry London. (2023) SUMOylation of the cardiac sodium channel NaV1.5 modifies inward current and cardiac excitability. Heart Rhythm 20:11, pages 1548-1557.
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Kathryn Braden, Harrison J. Stratton, Daniela Salvemini & Rajesh Khanna. (2022) Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain. Neurobiology of Pain 11, pages 100082.
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Song Cai, Aubin Moutal, Jie Yu, Lindsey A. Chew, Jörg Isensee, Reena ChawlaKimberly Gomez, Shizhen Luo, Yuan Zhou, Aude Chefdeville, Cynthia Madura, Samantha Perez-Miller, Shreya Sai Bellampalli, Angie DorameDavid D. ScottLiberty François-Moutal, Zhiming ShanTaylor Woodward, Vijay Gokhale, Andrea G. Hohmann, Todd W. VanderahMarcel Patek, May Khanna, Tim Hucho & Rajesh Khanna. (2021) Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Science Translational Medicine 13:619.
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Jiurong Cheng, Yingdong Deng & Jun Zhou. (2021) Role of the Ubiquitin System in Chronic Pain. Frontiers in Molecular Neuroscience 14.
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Li Shi & Naixia Zhang. (2021) Applications of Solution NMR in Drug Discovery. Molecules 26:3, pages 576.
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Aubin MoutalSong CaiJie YuHarrison J. StrattonAude ChefdevilleKimberly GomezDongzhi RanCynthia L. MaduraLisa BoinonMaira Soto, Yuan ZhouZhiming ShanLindsey A. ChewKathleen E. Rodgers & Rajesh Khanna. (2020) Studies on CRMP2 SUMOylation–deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain. Pain 161:11, pages 2629-2651.
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Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller, Aude Chefdeville, Lisa Boinon & Marcel Patek. (2020) Druggability of CRMP2 for Neurodegenerative Diseases. ACS Chemical Neuroscience 11:17, pages 2492-2505.
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Henry M. Colecraft & Rajesh Khanna. (2020) The 2019 FASEB Science Research Conference on Ion Channel Regulation: Molecules to Disease, July 7‐12, 2019, Lisbon, Portugal. The FASEB Journal 34:4, pages 4828-4831.
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Agustin Garcia-Caballero, Fang-Xiong Zhang, Lina Chen, Said M’Dahoma, Junting Huang & Gerald W. Zamponi. (2019) SUMOylation regulates USP5-Cav3.2 calcium channel interactions. Molecular Brain 12:1.
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Aubin Moutal, Katherine A. White, Aude Chefdeville, Rachel N. Laufmann, Peter F. Vitiello, Douglas Feinstein, Jill M. Weimer & Rajesh Khanna. (2019) Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions. Molecular Neurobiology 56:10, pages 6736-6755.
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Lindsey A. Chew, Shreya S. Bellampalli, Erik T. Dustrude & Rajesh Khanna. (2019) Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics. Biochemical Pharmacology 163, pages 9-20.
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