Channels, Volume 12, Issue 1 (2018)

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Channels, Volume 12, Issue 1 (2018)

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Article Addendum - Commissioned

Addendum
Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1)
Takafumi Kawai, Shoki Tatsumi, Shinji Kihara, Kenji Sakimura & Yasushi Okamura
Pages: 1-8
Published online: 17 Nov 2017
AbstractforMechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1) | Full Text | References | PDF (579.7 KB)
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Addendum
Modulation of SK channels regulates locomotor alternating bursting activity in the functionally-mature spinal cord
Amr A. Mahrous & Sherif M. Elbasiouny
Pages: 9-14
Published online: 17 Nov 2017
AbstractforModulation of SK channels regulates locomotor alternating bursting activity in the functionally-mature spinal cord | Full Text | References | PDF (594.4 KB)
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News & Views

News
PKC and calcium channel trafficking
Franz Hofmann
Pages: 15-16
Published online: 21 Nov 2017
CitationforPKC and calcium channel trafficking | Full Text | References | PDF (309 KB)
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Research Paper

Article
Cone dystrophy and ectopic synaptogenesis in a Cacna1f loss of function model of congenital stationary night blindness (CSNB2A)
D. M. Waldner, N. C. Giraldo Sierra, S. Bonfield, L. Nguyen, I. S. Dimopoulos, Y. Sauvé, W. K. Stell & N. T. Bech-Hansen
Pages: 17-33
Published online: 02 Jan 2018
AbstractforCone dystrophy and ectopic synaptogenesis in a Cacna1f loss of function model of congenital stationary night blindness (CSNB2A) | Full Text | References | PDF (1.8 MB)
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Article
Regulation of Kv1.4 potassium channels by PKC and AMPK kinases
Martin Nybo Andersen, Lasse Skibsbye, Arnela Saljic, Martin Zahle Larsen, Hanne Borger Rasmussen & Thomas Jespersen
Pages: 34-44
Published online: 22 Dec 2017
AbstractforRegulation of Kv1.4 potassium channels by PKC and AMPK kinases | Full Text | References | PDF (1 MB)
  • 1582 Views
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Autocommentary

Article Commentary
Endothelial biology and ATP-sensitive potassium channels
Qadeer Aziz, Yiwen Li & Andrew Tinker
Pages: 45-46
Published online: 02 Jan 2018
CitationforEndothelial biology and ATP-sensitive potassium channels | Full Text | References | PDF (381.3 KB)
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Short Communication

Rapid Communication
CRMP2 is necessary for Neurofibromatosis type 1 related pain
Aubin Moutal, Song Cai, Shizhen Luo, Raphaëlle Voisin & Rajesh Khanna
Pages: 47-50
Published online: 17 Jan 2018
AbstractforCRMP2 is necessary for Neurofibromatosis type 1 related pain | Full Text | References | PDF (580 KB)
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Addendum

Addendum
Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure
Juejin Wang, Guang Li, Dejie Yu, Yuk Peng Wong, Tan Fong Yong, Mui Cheng Liang, Ping Liao, Roger Foo, Uta C. Hoppe & Tuck Wah Soong
Pages: 51-57
Published online: 17 Jan 2018
AbstractforCharacterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure | Full Text | References | PDF (821.7 KB)
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Article Addendum

Addendum
Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs
Agustín Asuaje, Pedro Martín, Nicolás Enrique, Leandro Agustín Díaz Zegarra, Paola Smaldini, Guillermo Docena & Verónica Milesi
Pages: 58-64
Published online: 23 Jan 2018
AbstractforDiphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs | Full Text | References | PDF (761.9 KB)
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Brief Report

Brief Report
Modulation of TRPA1 channel activity by Cdk5 in sensory neurons
Michael A. Sulak Ph.D., Monica Ghosh M.Sc., Pritam Sinharoy Ph.D., Spencer R. Andrei Ph.D. & Derek S. Damron Ph.D.
Pages: 65-75
Published online: 30 Jan 2018
AbstractforModulation of TRPA1 channel activity by Cdk5 in sensory neurons | Full Text | References | PDF (721.2 KB)
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Autocommentary

Article Commentary
Arrhythmogenic triggers associated with Sudden Cardiac Death
Mena Abdelsayed, Colin H. Peters & Peter C. Ruben
Pages: 76-77
Published online: 13 Nov 2017
CitationforArrhythmogenic triggers associated with Sudden Cardiac Death | Full Text | References | PDF (349.7 KB)
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Article Commentary
ENT3 utilizes a pH Sensing Mechanism for Transport
Anusha Singh & Rajgopal Govindarajan
Pages: 78-80
Published online: 15 Nov 2017
First Page PreviewforENT3 utilizes a pH Sensing Mechanism for Transport | Full Text | References | PDF (397.4 KB)
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Research Paper

Article
Non-Decaying postsynaptics potentials and delayed spikes in hippocampal pyramidal neurons generated by a zero slope conductance created by the persistent Na+ current
Cesar C. Ceballos, Rodrigo F. O. Pena, Antônio C. Roque & Ricardo M. Leão
Pages: 81-88
Published online: 16 Feb 2018
AbstractforNon-Decaying postsynaptics potentials and delayed spikes in hippocampal pyramidal neurons generated by a zero slope conductance created by the persistent Na+ current | Full Text | References | PDF (603.6 KB)
  • 908 Views
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Article
Inactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions
Eshcar Meisel, William Tobelaim, Meidan Dvir, Yoni Haitin, Asher Peretz & Bernard Attali
Pages: 89-99
Published online: 01 Mar 2018
AbstractforInactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions | Full Text | References | PDF (1.1 MB)
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Reviews

Review
Sensing and regulation of cell volume – we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?
Trine L. Toft-Bertelsen, Brian R. Larsen & Nanna MacAulay
Pages: 100-108
Published online: 14 Mar 2018
AbstractforSensing and regulation of cell volume – we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? | Full Text | References | PDF (725.1 KB)
  • 2228 Views
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Research Paper

Article
The Venom of Ornithoctonus huwena affect the electrophysiological stability of neonatal rat ventricular myocytes by inhibiting sodium, potassium and calcium current
Sha Yan, Pengfei Huang, Ying Wang, Xiongzhi Zeng & Yiya Zhang
Pages: 109-118
Published online: 05 Apr 2018
AbstractforThe Venom of Ornithoctonus huwena affect the electrophysiological stability of neonatal rat ventricular myocytes by inhibiting sodium, potassium and calcium current | Full Text | References | PDF (883.3 KB)
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Article
TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells
Bin Zhang, Bei Liu, Carolyn M. Roos, Michael A. Thompson, Y. S. Prakash, Jordan D. Miller & Rui-wei Guo
Pages: 119-125
Published online: 10 Apr 2018
AbstractforTRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells | Full Text | References | PDF (856.4 KB)
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Review

Review
Pharmacologic targeting of endothelial Ca2+-activated K+ channels: A strategy to improve cardiovascular function
Cini Mathew John, Rayan Khaddaj Mallat, Grace George, Taeyeob Kim, Ramesh C. Mishra & Andrew P. Braun
Pages: 126-136
Published online: 16 Apr 2018
AbstractforPharmacologic targeting of endothelial Ca2+-activated K+ channels: A strategy to improve cardiovascular function | Full Text | References | PDF (637.4 KB)
  • 1575 Views
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Review
X-ray crystallography of TRP channels
Appu K. Singh, Luke L. McGoldrick, Kei Saotome & Alexander I. Sobolevsky
Pages: 137-152
Published online: 30 Apr 2018
AbstractforX-ray crystallography of TRP channels | Full Text | References | PDF (3 MB)
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Research Paper

Article
Dopamine-mediated calcium channel regulation in synaptic suppression in L. stagnalis interneurons
Nancy Dong, David W. K. Lee, Hong-Shuo Sun & Zhong-Ping Feng
Pages: 153-173
Published online: 08 May 2018
AbstractforDopamine-mediated calcium channel regulation in synaptic suppression in L. stagnalis interneurons | Full Text | References | PDF (1.6 MB)
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News and Views

Article Commentary
TRPM4 and the Emperor
J. Marc Simard & Volodymyr Gerzanich
Pages: 174-175
Published online: 17 May 2018
CitationforTRPM4 and the Emperor | Full Text | References | PDF (327.8 KB)
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Research Paper

Article
Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients
Rou-Mu Hu, David J. Tester, Ryan Li, Tianyu Sun, Blaise Z. Peterson, Michael J. Ackerman, Jonathan C. Makielski & Bi-Hua Tan
Pages: 176-186
Published online: 01 Aug 2018
AbstractforMexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients | Full Text | References | PDF (1.4 MB)
  • 1109 Views
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Review

Review
Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors
Robert Bähring
Pages: 187-200
Published online: 02 Aug 2018
AbstractforKv channel-interacting proteins as neuronal and non-neuronal calcium sensors | Full Text | References | PDF (1.5 MB)
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Review
Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia
Qing Zhang, Junjie Chen, Yao Qin, Juejin Wang & Lei Zhou
Pages: 201-218
Published online: 15 Aug 2018
AbstractforMutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia | Full Text | References | PDF (1.5 MB)
  • 5866 Views
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Research Paper

Article
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels
Liberty François-Moutal, David Donald Scott, Samantha Perez-Miller, Vijay Gokhale, May Khanna & Rajesh Khanna
Pages: 219-227
Published online: 06 Aug 2018
AbstractforChemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels | Full Text | References | PDF (2.3 MB)
  • 1655 Views
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Brief Report

Brief Report
Kv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ
Marlen Dierich & Michael G. Leitner
Pages: 228-239
Published online: 23 Aug 2018
AbstractforKv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ | Full Text | References | PDF (1.4 MB)
  • 780 Views
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Research Paper

Article
Conservation of the Ca2+-permeability through the voltage sensor domain of mammalian CatSper subunit
Hiroki Arima, Hidekazu Tsutsui & Yasushi Okamura
Pages: 240-248
Published online: 23 Aug 2018
AbstractforConservation of the Ca2+-permeability through the voltage sensor domain of mammalian CatSper subunit | Full Text | References | PDF (1.1 MB)
  • 973 Views
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Article
Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels
Pierre Costé de Bagneaux, Marta Campiglio, Bruno Benedetti, Petronel Tuluc & Bernhard E. Flucher
Pages: 249-261
Published online: 26 Sep 2018
AbstractforRole of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels | Full Text | References | PDF (2.5 MB)
  • 963 Views
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Review

Review
The synaptic action of Degenerin/Epithelial sodium channels
Alexis S. Hill & Yehuda Ben-Shahar
Pages: 262-275
Published online: 28 Aug 2018
AbstractforThe synaptic action of Degenerin/Epithelial sodium channels | Full Text | References | PDF (1.4 MB)
  • 1934 Views
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Research Paper

Article
Single channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D
Emely Thompson, Jodene Eldstrom & David Fedida
Pages: 276-283
Published online: 28 Aug 2018
AbstractforSingle channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D | Full Text | References | PDF (1.4 MB)
  • 754 Views
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Review

Review
Cystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure
Paul Linsdell
Pages: 284-290
Published online: 28 Aug 2018
AbstractforCystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure | Full Text | References | PDF (974.3 KB)
  • 6585 Views
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Review
Inward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism
Sylvia Y. M. Yao & James D. Young
Pages: 291-298
Published online: 28 Aug 2018
AbstractforInward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism | Full Text | References | PDF (1.3 MB)
  • 993 Views
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Research Paper

Article
Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants
Alessandro Alaimo, Ainhoa Etxeberria, Juan Camilo Gómez-Posada, Carolina Gomis-Perez, Juncal Fernández-Orth, Covadonga Malo & Alvaro Villarroel
Pages: 299-310
Published online: 26 Sep 2018
AbstractforLack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants | Full Text | References | PDF (1.6 MB)
  • 928 Views
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Autocommentary

Article Commentary
Bibliometric analysis of recent sodium channel research
Dongyi Zhao, Jianing Li, Corey Seehus, Xuan Huang, Meimi Zhao, Shiqi Zhang, Wuyang Wang, Hong-Long Ji & Feng Guo
Pages: 311-325
Published online: 29 Sep 2018
AbstractforBibliometric analysis of recent sodium channel research | Full Text | References | PDF (3.5 MB)
  • 2523 Views
  • 14 CrossRef citations
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Review

Review
In vitro and in vivo phosphorylation of the Cav2.3 voltage-gated R-type calcium channel
T. Schneider, S. Alpdogan, J. Hescheler & F. Neumaier
Pages: 326-334
Published online: 29 Sep 2018
AbstractforIn vitro and in vivo phosphorylation of the Cav2.3 voltage-gated R-type calcium channel | Full Text | References | PDF (1 MB)
  • 1407 Views
  • 5 CrossRef citations
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Review
The role of the unfolded protein response in arrhythmias
Man Liu & Samuel C Dudley Jr
Pages: 335-345
Published online: 29 Sep 2018
AbstractforThe role of the unfolded protein response in arrhythmias | Full Text | References | PDF (1.3 MB)
  • 1774 Views
  • 12 CrossRef citations
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Review
Role of the alternative splice variant of NCC in blood pressure control
Hila Wardak, Omar A.Z. Tutakhel & Jenny Van Der Wijst
Pages: 346-355
Published online: 21 Oct 2018
AbstractforRole of the alternative splice variant of NCC in blood pressure control | Full Text | References | PDF (1.2 MB)
  • 1292 Views
  • 3 CrossRef citations
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Review
Potassium channels in the sinoatrial node and their role in heart rate control
Qadeer Aziz, Yiwen Li & Andrew Tinker
Pages: 356-366
Published online: 21 Oct 2018
AbstractforPotassium channels in the sinoatrial node and their role in heart rate control | Full Text | References | PDF (1.1 MB)
  • 3208 Views
  • 13 CrossRef citations
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Research Paper

Article
Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
Mohammad-Reza Ghovanloo, Colin H. Peters & Peter C. Ruben
Pages: 367-377
Published online: 10 Nov 2018
AbstractforEffects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3 | Full Text | References | PDF (2.3 MB)
  • 2591 Views
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Brief Report

Brief Report
Role of individual S4 segments in gating of Cav3.1 T-type calcium channel by voltage
Bohumila Jurkovicova-Tarabova, Katarina Mackova, Lucia Moravcikova, Maria Karmazinova & Lubica Lacinova
Pages: 378-387
Published online: 22 Nov 2018
AbstractforRole of individual S4 segments in gating of Cav3.1 T-type calcium channel by voltage | Full Text | References | PDF (1.5 MB)
  • 1100 Views
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Research Paper

Article
Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels
Alexandra Pinggera, Giulia Negro, Petronel Tuluc, Morris J. Brown, Andreas Lieb & Jörg Striessnig
Pages: 388-402
Published online: 22 Nov 2018
AbstractforGating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels | Full Text | References | PDF (2.2 MB)
  • 1759 Views
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