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Original

Spermiogenesis and DNA Repair: A Possible Etiology of Human Infertility and Genetic Disorders

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Pages 3-10 | Received 17 Aug 2007, Accepted 23 Oct 2007, Published online: 09 Jul 2009

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Duangporn Jamsai, Anne E O’Connor, Liza O’Donnell, Jennifer Chi Yi Lo & Moira K O’Bryan. (2015) Uncoupling of transcription and translation of Fanconi anemia (FANC) complex proteins during spermatogenesis. Spermatogenesis 5:1.
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Armand Zini. (2011) Are sperm chromatin and DNA defects relevant in the clinic?. Systems Biology in Reproductive Medicine 57:1-2, pages 78-85.
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Seoyoung Kim, Shaun E. Peterson, Maria Jasin & Scott Keeney. (2016) Mechanisms of germ line genome instability. Seminars in Cell & Developmental Biology 54, pages 177-187.
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Aïda Pujol, Albert Obradors, Erica Esteo, Beatriz Costilla, Désireé García, Valerie Vernaeve & Rita Vassena. (2016) Oxidative stress level in fresh ejaculate is not related to semen parameters or to pregnancy rates in cycles with donor oocytes. Journal of Assisted Reproduction and Genetics 33:4, pages 529-534.
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Luna Samanta, Gayatri Mohanty & Ashok Agarwal. 2016. Recurrent Pregnancy Loss. Recurrent Pregnancy Loss 109 129 .
Sezgin Gunes, Maha Al-Sadaan & Ashok Agarwal. (2015) Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility. Reproductive BioMedicine Online 31:3, pages 309-319.
Crossref
Damiano Pizzol, Alessandro Bertoldo & Carlo Foresta. (2014) Male infertility: biomolecular aspects. Biomolecular Concepts 5:6, pages 449-456.
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Laia Vergés, Òscar Molina, Esther Geán, Francesca Vidal & Joan Blanco. (2014) Deletions and duplications of the 22q11.2 region in spermatozoa from DiGeorge/velocardiofacial fathers. Molecular Cytogenetics 7:1.
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Anais Noblanc, Ayhan Kocer & Joël R Drevet. (2014) Recent knowledge concerning mammalian sperm chromatin organization and its potential weaknesses when facing oxidative challenge. Basic and Clinical Andrology 24:1.
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Chong Chen, David S. Cram, Fanni Xie, Ping Wang, Xueqin Xu, Huanzheng Li, Zhuo Song, Di Chen, Jianguang Zhang & Shaohua Tang. (2014) A pregnancy with discordant fetal and placental chromosome 18 aneuploidies revealed by invasive and noninvasive prenatal diagnosis. Reproductive BioMedicine Online 29:1, pages 136-139.
Crossref
C. Wright, S. Milne & H. Leeson. (2014) Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility. Reproductive BioMedicine Online 28:6, pages 684-703.
Crossref
A. Zini, O. Albert & B. Robaire. (2014) Assessing sperm chromatin and DNA damage: clinical importance and development of standards. Andrology 2:3, pages 322-325.
Crossref
Stephanie Belloc, Moncef Benkhalifa, Martine Cohen-Bacrie, Alain Dalleac, Hikmat Chahine, Edouard Amar & Armand Zini. (2014) Which isolated sperm abnormality is most related to sperm DNA damage in men presenting for infertility evaluation. Journal of Assisted Reproduction and Genetics 31:5, pages 527-532.
Crossref
Franck Pellestor, Vincent Gatinois, Jacques Puechberty, David Geneviève & Geneviève Lefort. (2014) Le chromothripsis . médecine/sciences 30:3, pages 266-273.
Crossref
Khaled Habas, Diana Anderson & Martin Brinkworth. (2014) Development of an in vitro test system for assessment of male, reproductive toxicity. Toxicology Letters 225:1, pages 86-91.
Crossref
Abdullah Alkhayal, Maria San Gabriel, Krista Zeidan, Khalid Alrabeeah, Diana Noel, Rachelle McGraw, Francois Bissonnette, Isaac Jacques Kadoch & Armand Zini. (2013) Sperm DNA and chromatin integrity in semen samples used for intrauterine insemination. Journal of Assisted Reproduction and Genetics 30:11, pages 1519-1524.
Crossref
Marta Olszewska, Monika Fraczek, Nataliya Huleyuk, Anna Czernikiewicz, Ewa Wiland, Magdalena Boksa, Danuta Zastavna, Barbara Panasiuk, Alina T. Midro & Maciej Kurpisz. (2013) Chromatin structure analysis of spermatozoa from reciprocal chromosome translocation (RCT) carriers with known meiotic segregation patterns. Reproductive Biology 13:3, pages 209-220.
Crossref
Wigard P Kloosterman & Edwin Cuppen. (2013) Chromothripsis in congenital disorders and cancer: similarities and differences. Current Opinion in Cell Biology 25:3, pages 341-348.
Crossref
Tadayuki Ayabe, Keiko Matsubara, Tsutomu Ogata, Atsuko Ayabe, Nobuyuki Murakami, Toshiro Nagai & Maki Fukami. (2013) Birth seasonality in Prader‐Willi syndrome resulting from chromosome 15 microdeletion. American Journal of Medical Genetics Part A 161:6, pages 1495-1497.
Crossref
Carlos Díaz-Castillo. (2013) Females and Males Contribute in Opposite Ways to the Evolution of Gene Order in Drosophila. PLoS ONE 8:5, pages e64491.
Crossref
Giovanni Ruvolo, Maria Carmela Roccheri, Anna Maria Brucculeri, Salvatore Longobardi, Ettore Cittadini & Liana Bosco. (2013) Lower sperm DNA fragmentation after r-FSH administration in functional hypogonadotropic hypogonadism. Journal of Assisted Reproduction and Genetics 30:4, pages 497-503.
Crossref
Duangporn Jamsai, Anne E. O’Connor, Kathleen D. DeBoer, Brett J. Clark, Stephanie J. Smith, Catherine M. Browne, Jonathan G. Bensley, Julie A. Merriman, Wai Shan Yuen, Peter Koopman, Keith T. Jones & Moira K. O’Bryan. (2013) Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse. PLoS ONE 8:2, pages e56955.
Crossref
T. B. Smith, M. D. Dun, N. D. Smith, B. J. Curry, H. S. Connaughton & R. J. Aitken. (2013) The presence of a truncated base excision repair pathway in human spermatozoa, Mediated by OGG1. Journal of Cell Science.
Crossref
Rafael Oliva & Judit Castillo. 2013. Sperm Chromatin for the Researcher. Sperm Chromatin for the Researcher 23 43 .
Mona Bungum, Aleksander Giwercman & Marcello Spanò. 2013. Sperm Chromatin for the Clinician. Sperm Chromatin for the Clinician 117 136 .
Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari & Serena D’Souza. (2012) Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones. Clinical Epigenetics 4:1.
Crossref
Aabida SaferaliSanny MoussetteDonovan ChanJacquetta TraslerTaiping ChenRima RozenAnna K. Naumova. (2012) DNA methyltransferase 1 ( Dnmt1 ) mutation affects Snrpn imprinting in the mouse male germ line . Genome 55:09, pages 673-682.
Crossref
Eugenia Cordelli, Patrizia Eleuteri, Maria Giuseppa Grollino, Barbara Benassi, Giovanni Blandino, Cecilia Bartoleschi, Maria Chiara Pardini, Edoardo Vittorio Di Caprio, Marcello Spanò, Francesca Pacchierotti & Paola Villani. (2012) Direct and delayed X‐ray‐induced DNA damage in male mouse germ cells. Environmental and Molecular Mutagenesis 53:6, pages 429-439.
Crossref
S. Keshtgar, H. Fanaei, S. Bahmanpour, F. Azad, A. Ghannadi & M. Kazeroni. (2012) In vitro effects of α-tocopherol on teratozoospermic semen samples. Andrologia 44, pages 721-727.
Crossref
K. Steger, M. C. O. Cavalcanti & H. C. Schuppe. (2011) Prognostic markers for competent human spermatozoa: fertilizing capacity and contribution to the embryo. International Journal of Andrology 34:6pt1, pages 513-527.
Crossref
Kim Dao Ly, Ashok Agarwal & Zsolt Peter Nagy. (2011) Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?. Journal of Assisted Reproduction and Genetics 28:9, pages 833-849.
Crossref
Jeanne Perrin, Virginie Tassistro, Odile Paulmyer-Lacroix, Blandine Courbière, Alain Botta & Irène Sari-Minodier. (2011) In smokers, swim-up and discontinuous gradient centrifugation recover spermatozoa with equally lower amounts of DNA damage than spermatozoa obtained from neat semen. Fertility and Sterility 95:8, pages 2680-2682.
Crossref
A. E. Calogero, S. La Vignera, R. A. Condorelli, A. Perdichizzi, D. Valenti, P. Asero, U. Carbone, B. Boggia, N. De Rosa, G. Lombardi, R. D’Agata, L. O. Vicari, E. Vicari & M. De Rosa. (2010) Environmental car exhaust pollution damages human sperm chromatin and DNA. Journal of Endocrinological Investigation 34:6, pages e139-e143.
Crossref
Kamla Kant Shukla, Abbas Ali Mahdi, Vivek Mishra, Singh Rajender, Satya Narain Sankhwar, Devender Patel & Mukul Das. (2011) Withania somnifera improves semen quality by combating oxidative stress and cell death and improving essential metal concentrations. Reproductive BioMedicine Online 22:5, pages 421-427.
Crossref
Graham D Johnson, Claudia Lalancette, Amelia K Linnemann, Frédéric Leduc, Guylain Boissonneault & Stephen A Krawetz. (2011) The sperm nucleus: chromatin, RNA, and the nuclear matrix. REPRODUCTION 141:1, pages 21-36.
Crossref
P. de Boer, M. de Vries & S. Gochhait. 2011. Epigenetics and Human Reproduction. Epigenetics and Human Reproduction 187 212 .
Rafael Oliva & Sara de Mateo. 2011. Epigenetics and Human Reproduction. Epigenetics and Human Reproduction 45 83 .
Liliana Ramos & Peter de Boer. 2011. Biennial Review of Infertility. Biennial Review of Infertility 227 243 .
Rafael Oliva & Judit Castillo. 2011. Sperm Chromatin. Sperm Chromatin 45 60 .
Mona Bungum, Aleksander Giwercman & Marcello Spanò. 2011. Sperm Chromatin. Sperm Chromatin 321 335 .
Xifeng Zhang, Qian Zhang, Jun Zhang, Li Qiu, Shuang-shuang Yan, Juling Feng, Yan Sun, Xingxu Huang, Karen H Lu & Zheng Li. (2010) FATS is a transcriptional target of p53 and associated with antitumor activity. Molecular Cancer 9:1.
Crossref
H Kurahashi, H Inagaki, T Ohye, H Kogo, M Tsutsumi, T Kato, M Tong & BS Emanuel. (2010) The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements. Clinical Genetics 78:4, pages 299-309.
Crossref
O. Molina, J. Blanco & F. Vidal. (2010) Deletions and duplications of the 15q11-q13 region in spermatozoa from Prader-Willi syndrome fathers. Molecular Human Reproduction 16:5, pages 320-328.
Crossref
Ashok Agarwal, Reda Z Mahfouz, Rakesh K Sharma, Oli Sarkar, Devna Mangrola & Premendu P Mathur. (2009) Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes. Reproductive Biology and Endocrinology 7:1.
Crossref
Mirella L. Meyer-Ficca, Julia Lonchar, Christine Credidio, Motomasa Ihara, Yun Li, Zhao-Qi Wang & Ralph G. Meyer. (2009) Disruption of Poly(ADP-Ribose) Homeostasis Affects Spermiogenesis and Sperm Chromatin Integrity in Mice1. Biology of Reproduction 81:1, pages 46-55.
Crossref
. (2009) Current World Literature. Current Opinion in Obstetrics & Gynecology 21:3, pages 296-300.
Crossref
Aris Polyzos, Thomas Ernst Schmid, Belem Piña-Guzmán, Betzabet Quintanilla-Vega & Francesco Marchetti. (2009) Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse. Toxicology and Applied Pharmacology 237:3, pages 298-305.
Crossref
Omar L. Kantidze & Sergey V. Razin. (2009) Chromatin loops, illegitimate recombination, and genome evolution. BioEssays 31:3, pages 278-286.
Crossref
Louis Hermo, R.-Marc Pelletier, Daniel G. Cyr & Charles E. Smith. (2009) Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: Changes in spermatid organelles associated with development of spermatozoa. Microscopy Research and Technique, pages NA-NA.
Crossref

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