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mAbs Volume 7, 2015 - Issue 6
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Rapid quantitative analysis of monoclonal antibody heavy and light chain charge heterogeneity

Ram P VanamPre-Clinical Development and Protein Chemistry, Regeneron Pharmaceuticals, Inc.; Tarrytown, NYUSA
,
Michael A SchneiderPre-Clinical Development and Protein Chemistry, Regeneron Pharmaceuticals, Inc.; Tarrytown, NYUSA
&
Michael S MarlowPre-Clinical Development and Protein Chemistry, Regeneron Pharmaceuticals, Inc.; Tarrytown, NYUSACorrespondence[email protected]
Pages 1118-1127 | Received 12 Jun 2015, Accepted 17 Aug 2015, Published online: 18 Sep 2015

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Fengfei Ma, Fahimeh Raoufi, Marc Andre Bailly, Laurence Fayadat-Dilman & Daniela Tomazela. (2020) Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies. mAbs 12:1.
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Articles from other publishers (12)

Tarun Gupta, Anuj Kumar & Sriram Seshadri. (2023) Bioprocess Challenges in Purification of Therapeutic Protein Charge Variants. Biotechnology and Bioprocess Engineering 28:4, pages 493-506.
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Jiaqi Wu, Will McElroy, Janusz Pawliszyn & Christopher D. Heger. (2022) Imaged capillary isoelectric focusing: Applications in the pharmaceutical industry and recent innovations of the technology. TrAC Trends in Analytical Chemistry 150, pages 116567.
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Ramesh Kumar, Andras Guttman & Anurag S. Rathore. (2021) Applications of capillary electrophoresis for biopharmaceutical product characterization. ELECTROPHORESIS 43:1-2, pages 143-166.
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Meral Yüce, Fatma Sert, Milad Torabfam, Ayhan Parlar, Büşra Gürel, Nilüfer Çakır, Duygu E. Dağlıkoca, Mansoor A. Khan & Yılmaz Çapan. (2021) Fractionated charge variants of biosimilars: A review of separation methods, structural and functional analysis. Analytica Chimica Acta 1152, pages 238189.
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Meriem Dadouch, Yoann Ladner & Catherine Perrin. (2021) Analysis of Monoclonal Antibodies by Capillary Electrophoresis: Sample Preparation, Separation, and Detection. Separations 8:1, pages 4.
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Shu-Ying Jing, Jin-Xia Gou, Dong Gao, Hai-Bin Wang, Shan-Jing Yao & Dong-Qiang Lin. (2020) Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization. Separation and Purification Technology 235, pages 116136.
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Anne Trappe, Florian Füssl, Sara Carillo, Izabela Zaborowska, Paula Meleady & Jonathan Bones. (2018) Rapid charge variant analysis of monoclonal antibodies to support lead candidate biopharmaceutical development. Journal of Chromatography B 1095, pages 166-176.
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Stanley Chung, Jun Tian, Zhijun Tan, Jie Chen, Jongchan Lee, Michael Borys & Zheng Jian Li. (2018) Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles. Biotechnology and Bioengineering 115:7, pages 1646-1665.
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Deepti Ahluwalia, Madesh Belakavadi, Tapan K. Das & Amit Katiyar. (2018) A three-point identity criteria tool for establishing product identity using icIEF method. Journal of Chromatography B 1083, pages 271-277.
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Wenhua Li, Bin Yang, Dongmei Zhou, Jun Xu, Wenjia Li & Wen-Chen Suen. (2017) Identification and characterization of monoclonal antibody fragments cleaved at the complementarity determining region using orthogonal analytical methods. Journal of Chromatography B 1048, pages 121-129.
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Rabah Gahoual, Alain Beck, Emmanuelle Leize-Wagner & Yannis-Nicolas François. (2016) Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products. Journal of Chromatography B 1032, pages 61-78.
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Szabolcs Fekete, Davy Guillarme, Pat Sandra & Koen Sandra. (2015) Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein Biopharmaceuticals. Analytical Chemistry 88:1, pages 480-507.
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