mAbs, Volume 7, Issue 6 (2015)

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mAbs, Volume 7, Issue 6 (2015)

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Meeting Preview

Meeting Report
Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7–10, 2015, San Diego, CA
Paul W H I Parren, Dennis R Burton, Andrew Bradbury, James S Huston, Paul J Carter, Trudi Veldman, Kerry A Chester, James W Larrick, Mark R Alfenito, Jamie K Scott, Louis M Weiner, Gregory P Adams & Janice M Reichert
Pages: 981-988
Published online: 30 Sep 2015
AbstractforAntibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7–10, 2015, San Diego, CA | Full Text | PDF (120.5 KB)
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Perspective

Antibody-drug conjugates: Intellectual property considerations
Ulrich Storz
Pages: 989-1009
Published online: 18 Sep 2015
AbstractforAntibody-drug conjugates: Intellectual property considerations | Full Text | References | PDF (636.4 KB) | Supplemental
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Review

Specific in vivo knockdown of protein function by intrabodies
Andrea LJ Marschall , Stefan Dübel & Thomas Böldicke
Pages: 1010-1035
Published online: 18 Sep 2015
AbstractforSpecific in vivo knockdown of protein function by intrabodies | Full Text | References | PDF (608.4 KB)
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Brief Report

Brief Report
A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography
Robert E Birdsall, Henry Shion, Frank W Kotch, April Xu, Thomas J Porter & Weibin Chen
Pages: 1036-1044
Published online: 18 Sep 2015
AbstractforA rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography | Full Text | References | PDF (845.7 KB) | Supplemental
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Report

Antibody humanization by structure-based computational protein design
Yoonjoo Choi, Casey Hua, Charles L Sentman, Margaret E Ackerman & Chris Bailey-Kellogg
Pages: 1045-1057
Published online: 11 Sep 2015
AbstractforAntibody humanization by structure-based computational protein design | Full Text | References | PDF (909.3 KB) | Supplemental
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Stability engineering of anti-EGFR scFv antibodies by rational design of a lambda-to-kappa swap of the VL framework using a structure-guided approach
Andreas Lehmann, Josephine H F Wixted, Maxim V Shapovalov, Heinrich Roder, Roland L Dunbrack Jr. & Matthew K Robinson
Pages: 1058-1071
Published online: 25 Sep 2015
AbstractforStability engineering of anti-EGFR scFv antibodies by rational design of a lambda-to-kappa swap of the VL framework using a structure-guided approach | Full Text | References | PDF (1.2 MB) | Supplemental
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Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1
Haixia Wu, Kristopher Truncali, Julie Ritchie, Rachel Kroe-Barrett, Sanjaya Singh, Anne S Robinson & Christopher J Roberts
Pages: 1072-1083
Published online: 18 Sep 2015
AbstractforWeak protein interactions and pH- and temperature-dependent aggregation of human Fc1 | Full Text | References | PDF (753.1 KB) | Supplemental
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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies
Amita Datta-Mannan, Jirong Lu, Derrick R Witcher, Donmienne Leung, Ying Tang & Victor J Wroblewski
Pages: 1084-1093
Published online: 04 Sep 2015
AbstractforThe interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies | Full Text | References | PDF (384.5 KB)
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Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins
Shen Luo & Baolin Zhang
Pages: 1094-1103
Published online: 25 Sep 2015
AbstractforDextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins | Full Text | References | PDF (595.2 KB)
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Performance metrics for evaluating system suitability in liquid chromatography—Mass spectrometry peptide mass mapping of protein therapeutics and monoclonal antibodies
Mowei Zhou, Ashley C Gucinski & Michael T Boyne II
Pages: 1104-1117
Published online: 04 Sep 2015
AbstractforPerformance metrics for evaluating system suitability in liquid chromatography—Mass spectrometry peptide mass mapping of protein therapeutics and monoclonal antibodies | Full Text | References | PDF (1.3 MB) | Supplemental
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Rapid quantitative analysis of monoclonal antibody heavy and light chain charge heterogeneity
Ram P Vanam, Michael A Schneider & Michael S Marlow
Pages: 1118-1127
Published online: 18 Sep 2015
AbstractforRapid quantitative analysis of monoclonal antibody heavy and light chain charge heterogeneity | Full Text | References | PDF (441.1 KB) | Supplemental
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Toward the complete characterization of host cell proteins in biotherapeutics via affinity depletions, LC-MS/MS, and multivariate analysis
James A Madsen, Victor Farutin, Theresa Carbeau, Steve Wudyka, Yan Yin, Stephen Smith, James Anderson & Ishan Capila
Pages: 1128-1137
Published online: 18 Sep 2015
AbstractforToward the complete characterization of host cell proteins in biotherapeutics via affinity depletions, LC-MS/MS, and multivariate analysis | Full Text | References | PDF (631.5 KB) | Supplemental
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Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)
Minoru Tada, Ken-Ichiro Tatematsu, Akiko Ishii-Watabe, Akira Harazono, Daisuke Takakura, Noritaka Hashii, Hideki Sezutsu & Nana Kawasaki
Pages: 1138-1150
Published online: 18 Sep 2015
AbstractforCharacterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori) | Full Text | References | PDF (1 MB) | Supplemental
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The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β
Jean-Michel Rondeau, Paul Ramage, Mauro Zurini & Hermann Gram
Pages: 1151-1160
Published online: 18 Sep 2015
AbstractforThe molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β | Full Text | References | PDF (716 KB) | Supplemental
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Development of human-like scFv-Fc antibodies neutralizing Botulinum toxin serotype B
Christine Rasetti-Escargueil, Arnaud Avril, Siham Chahboun, Rob Tierney, Nicola Bak, Sebastian Miethe, Christelle Mazuet, Michel R Popoff, Philippe Thullier, Michael Hust, Thibaut Pelat & Dorothea Sesardic
Pages: 1161-1177
Published online: 18 Sep 2015
AbstractforDevelopment of human-like scFv-Fc antibodies neutralizing Botulinum toxin serotype B | Full Text | References | PDF (672.4 KB) | Supplemental
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A potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis
Shirley Lam, Min Nyo, Patchara Phuektes, Chow Wenn Yew, Yee Joo Tan & Justin Jang Hann Chu
Pages: 1178-1194
Published online: 18 Sep 2015
AbstractforA potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis | Full Text | References | PDF (1.9 MB) | Supplemental
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Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis
Dong Geon Kim, Younggeon Jin, Juyoun Jin, Heekyoung Yang, Kyeung Min Joo, Weon Sup Lee, Sang Ryeol Shim, Sung-Woo Kim, Jinsang Yoo, Sang Hoon Lee, Jin-San Yoo & Do-Hyun Nam
Pages: 1195-1204
Published online: 18 Sep 2015
AbstractforAnticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis | Full Text | References | PDF (695.1 KB) | Supplemental
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Therapeutic drug monitoring of eculizumab: Rationale for an individualized dosing schedule
Philippe Gatault, Guillaume Brachet, David Ternant, Danielle Degenne, Guillaume Récipon, Christelle Barbet, Emmanuel Gyan, Valérie Gouilleux-Gruart, Cécile Bordes, Alexandra Farrell, Jean Michel Halimi & Hervé Watier
Pages: 1205-1211
Published online: 26 Sep 2015
AbstractforTherapeutic drug monitoring of eculizumab: Rationale for an individualized dosing schedule | Full Text | References | PDF (297.6 KB) | Supplemental
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Immunodiagnosis of platelet activation in immune thrombocytopenia through scFv antibodies cognate to activated IIb3 integrins
Preeti Bhoria, Neelam Varma, Pankaj Malhotra, Subhash Varma & Manni Luthra-Guptasarma
Pages: 1212-1220
Published online: 11 Sep 2015
AbstractforImmunodiagnosis of platelet activation in immune thrombocytopenia through scFv antibodies cognate to activated IIb3 integrins | Full Text | References | PDF (537 KB) | Supplemental
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