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mAbs Volume 8, 2016 - Issue 1
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Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody

Roy EylensteinMorphoSys AG; Lena-Christ-Str. 48; 82152Martinsried; Germany;These authors contributed equally to this work.
,
Daniel WeinfurtnerMorphoSys AG; Lena-Christ-Str. 48; 82152Martinsried; Germany;These authors contributed equally to this work.
,
Stefan HärtleMorphoSys AG; Lena-Christ-Str. 48; 82152Martinsried; Germany
,
Ralf StrohnerMorphoSys AG; Lena-Christ-Str. 48; 82152Martinsried; Germany
,
Jark BöttcherProteros Biostructures GmbH; Bunsenstr. 7a; 82152Martinsried; Germany; Current affiliation: Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11,1121 Vienna, Austria
,
Martin AugustinProteros Biostructures GmbH; Bunsenstr. 7a; 82152Martinsried; Germany
,
Ralf OstendorpMorphoSys AG; Lena-Christ-Str. 48; 82152Martinsried; Germany
&
Stefan SteidlMorphoSys AG; Lena-Christ-Str. 48; 82152Martinsried; GermanyCorrespondence[email protected]
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Pages 176-186 | Received 13 Jul 2015, Accepted 18 Sep 2015, Published online: 15 Oct 2015

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Urmi Dhagat, Timothy R. Hercus, Sophie E. Broughton, Tracy L. Nero, Karen S. Cheung Tung Shing, Emma F. Barry, Christy A. Thomson, Steve Bryson, Emil F. Pai, Barbara J. McClure, John W. Schrader, Angel F. Lopez & Michael W. Parker. (2018) The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. mAbs 10:7, pages 1018-1029.
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Peter C Taylor, Michael E Weinblatt, Iain B McInnes, Tatsuya Atsumi, Vibeke Strand, Tsutomu Takeuchi, Marguerite Bracher, David Brooks, John Davies, Christopher Goode, Anubha Gupta, Sumanta Mukherjee, Ciara O’Shea, Didier Saurigny, Lorrie A Schifano, Celia Shelton, Julia E Smith, Millie Wang, Reena Wang, Sarah Watts & Roy M Fleischmann. (2023) Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3). Annals of the Rheumatic Diseases 82:12, pages 1527-1537.
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Hélène Salvator, Aristine Cheng, Lindsey B. Rosen, Peter R. Williamson, John E. Bennett, Anuj. Kashyap, Li Ding, Kyung J. Kwon-Chung, Ho Namkoong, Christa S. Zerbe & Steven M. Holland. (2022) Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis. Respiratory Research 23:1.
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Monica L. Fernández-Quintero, Anna Vangone, Johannes R. Loeffler, Clarissa A. Seidler, Guy Georges & Klaus R. Liedl. (2022) Paratope states in solution improve structure prediction and docking. Structure 30:3, pages 430-440.e3.
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Brandon Becker, Kimberly Raymond, Carol Hawkes, April Mitchell Foster, Andrew Lovley, Cory Saucier, Avery A. Rizio, Jakob Bue Bjorner & Mark Kosinski. (2021) Qualitative and psychometric approaches to evaluate the PROMIS pain interference and sleep disturbance item banks for use in patients with rheumatoid arthritis. Journal of Patient-Reported Outcomes 5:1.
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Martin Domnowski, Ken Lo Presti, Jonas Binder, Josef Reindl, Lucille Lehmann, Felix Kummer, Meike Wolber, Marion Satzger, Marco Dehling, Jan Jaehrling & Wolfgang Frieß. (2020) Generation of mAb Variants with Less Attractive Self-Interaction but Preserved Target Binding by Well-Directed Mutation. Molecular Pharmaceutics 18:1, pages 236-245.
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Eeva-Christine Brockmann, Mikko Pyykkö, Heidi Hannula, Kamran Khan, Urpo Lamminmäki & Tuomas Huovinen. (2021) Combinatorial mutagenesis with alternative CDR-L1 and -H2 loop lengths contributes to affinity maturation of antibodies. New Biotechnology 60, pages 173-182.
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Christopher D Buckley, Jesus A Simón-Campos, Vyacheslav Zhdan, Brandon Becker, Katherine Davy, Elena Fisheleva, Anubha Gupta, Carol Hawkes, David Inman, Mark Layton, Nina Mitchell, Jatin Patel, Didier Saurigny, Russell Williamson & Paul P Tak. (2020) Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: a randomised, phase 2b, dose-ranging study. The Lancet Rheumatology 2:11, pages e677-e688.
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Mark C Genovese, Mario Berkowitz, Philip G Conaghan, Charles Peterfy, Katherine Davy, Elena Fisheleva, Anubha Gupta, David Inman, Robert Janiczek, Mark Layton, Nina Mitchell, Jatin Patel, Alexandra Roberts, Didier Saurigny, Julia E Smith, Russell Williamson & Paul P Tak. (2020) MRI of the joint and evaluation of the granulocyte–macrophage colony-stimulating factor–CCL17 axis in patients with rheumatoid arthritis receiving otilimab: a phase 2a randomised mechanistic study. The Lancet Rheumatology 2:11, pages e666-e676.
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Laurie Toullec, Frédéric Batteux, Pietro Santulli, Sandrine Chouzenoux, Mohamed Jeljeli, Thibaut Belmondo, Sophie Hue & Charles Chapron. (2020) High Levels of Anti-GM-CSF Antibodies in Deep Infiltrating Endometriosis. Reproductive Sciences 27:1, pages 211-217.
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Rob van der Kant, Joschka Bauer, Anne R Karow-Zwick, Sebastian Kube, Patrick Garidel, Michaela Blech, Frederic Rousseau & Joost Schymkowitz. (2019) Adaption of human antibody λ and κ light chain architectures to CDR repertoires. Protein Engineering, Design and Selection 32:3, pages 109-127.
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Clement Angkawidjaja & Takashi Torashima. (2019) Crystal structure of the Fab region of a neutralizing antibody against granulocyte-macrophage colony-stimulating factor. Acta Crystallographica Section F Structural Biology Communications 75:10, pages 634-639.
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S. Veugelen, M. Dewilde, B. De Strooper & L. Chávez-Gutiérrez. 2017. Enzymology at the Membrane Interface: Intramembrane Proteases. Enzymology at the Membrane Interface: Intramembrane Proteases 59 97 .

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