mAbs, Volume 8, Issue 1 (2016)

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mAbs, Volume 8, Issue 1 (2016)

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Perspective

Article Commentary
The INNs and outs of antibody nonproprietary names
Tim D. Jones, Paul J. Carter, Andreas Plückthun, Max Vásquez, Robert G.E. Holgate, Isidro Hötzel, Andrew G. Popplewell, Paul W.H.I. Parren, Markus Enzelberger, Hendrik J. Rademaker, Michael R. Clark, David C. Lowe, Bassil I. Dahiyat, Victoria Smith, John M. Lambert, Herren Wu, Mary Reilly, John S. Haurum, Stefan Dübel, James S. Huston, Thomas Schirrmann, Richard A.J. Janssen, Martin Steegmaier, Jane A. Gross, Andrew R.M. Bradbury, Dennis R. Burton, Dimiter S. Dimitrov, Kerry A. Chester, Martin J. Glennie, Julian Davies, Adam Walker, Steve Martin, John McCafferty & Matthew P. Baker
Pages: 1-9
Published online: 30 Dec 2015
AbstractforThe INNs and outs of antibody nonproprietary names | Full Text | References | PDF (227.5 KB)
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Open Access
Article Commentary
Intellectual property issues of immune checkpoint inhibitors
Ulrich Storz
Pages: 10-26
Published online: 23 Nov 2015
AbstractforIntellectual property issues of immune checkpoint inhibitors | Full Text | References | PDF (332.9 KB)
  • 4835 Views
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Free Access
Article Commentary
The European antibody network's practical guide to finding and validating suitable antibodies for research
Giovanna Roncador, Pablo Engel, Lorena Maestre, Amanda P. Anderson, Jacqueline L. Cordell, Mark S. Cragg, Vladka Č. Šerbec, Margaret Jones, Vanda J. Lisnic, Leonor Kremer, Demin Li, Friedrich Koch-Nolte, Núria Pascual, Jose-Ignacio Rodríguez-Barbosa, Ruurd Torensma, Helen Turley, Karen Pulford & Alison H. Banham
Pages: 27-36
Published online: 15 Oct 2015
AbstractforThe European antibody network's practical guide to finding and validating suitable antibodies for research | Full Text | References | PDF (274.4 KB)
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Open Access

Short Communication

Rapid Communication
A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells
Chiara V. Segré, Silvia Senese, Sara Loponte, Stefano Santaguida, Paolo Soffientini, Gabriela Grigorean, Mario Cinquanta, Giuseppe Ossolengo, Christian Seiser & Susanna Chiocca
Pages: 37-42
Published online: 14 Oct 2015
AbstractforA monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells | Full Text | References | PDF (515.8 KB) | Supplemental
  • 832 Views
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Rapid Communication
Computational tool for the early screening of monoclonal antibodies for their viscosities
Neeraj J Agrawal, Bernhard Helk, Sandeep Kumar, Neil Mody, Hasige A. Sathish, Hardeep S. Samra, Patrick M Buck, Li Li & Bernhardt L Trout
Pages: 43-48
Published online: 15 Oct 2015
AbstractforComputational tool for the early screening of monoclonal antibodies for their viscosities | Full Text | References | PDF (314.4 KB) | Supplemental
  • 5042 Views
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Brief Report

Brief Report
Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry
Wolfgang Schaefer, Hans R Völger, Stefan Lorenz, Sabine Imhof-Jung, Jörg T Regula, Christian Klein & Michael Mølhøj
Pages: 49-55
Published online: 09 Dec 2015
AbstractforHeavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry | Full Text | References | PDF (503.7 KB)
  • 2728 Views
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Report

Report
Multi-Site N-glycan mapping study 1: Capillary electrophoresis – laser induced fluorescence
Ákos Szekrényes, SungAe Suhr Park, Marcia Santos, Clarence Lew, Aled Jones, Ted Haxo, Michael Kimzey, Shiva Pourkaveh, Zoltán Szabó, Zoran Sosic, Peng Feng, Csaba Váradi, François de l'Escaille, Jean-Bernard Falmagne, Preeti Sejwal, Thomas Niedringhaus, David Michels, Gordon Freckleton, Melissa Hamm, Anastasiya Manuilov, Melissa Schwartz, Jiann-Kae Luo, Jonathan van Dyck, Pui-King Leung, Marcell Olajos, Yingmei Gu, Kai Gao, Wenbo Wang, Jo Wegstein, Samnang Tep & András Guttman
Pages: 56-64
Published online: 09 Dec 2015
AbstractforMulti-Site N-glycan mapping study 1: Capillary electrophoresis – laser induced fluorescence | Full Text | References | PDF (707.1 KB) | Supplemental
  • 3081 Views
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Open Access
Report
Calcium-dependent antigen binding as a novel modality for antibody recycling by endosomal antigen dissociation
N Hironiwa, S Ishii, S Kadono, Y Iwayanagi, F Mimoto, K Habu, T Igawa & K Hattori
Pages: 65-73
Published online: 19 Dec 2015
AbstractforCalcium-dependent antigen binding as a novel modality for antibody recycling by endosomal antigen dissociation | Full Text | References | PDF (652.3 KB) | Supplemental
  • 3640 Views
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Open Access
Report
A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA
Gerard JA Rouwendal, Miranda M van der Lee, Saskia Meyer, Karli R Reiding, Jan Schouten, Guy de Roo, David F Egging, Jeanette HW Leusen, Peter Boross, Manfred Wuhrer, Gijs F Verheijden, Wim H Dokter, Marco Timmers & Ruud Ubink
Pages: 74-86
Published online: 27 Oct 2015
AbstractforA comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA | Full Text | References | PDF (858.1 KB) | Supplemental
  • 2553 Views
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Report
Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting
Saskia Meyer, Maaike Nederend, J.H. Marco Jansen, Karli R. Reiding, Shamir R. Jacobino, Jan Meeldijk, Niels Bovenschen, Manfred Wuhrer, Thomas Valerius, Ruud Ubink, Peter Boross, Gerard Rouwendal & Jeanette H.W. Leusen
Pages: 87-98
Published online: 23 Nov 2015
AbstractforImproved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting | Full Text | References | PDF (1 MB) | Supplemental
  • 3870 Views
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Open Access
Report
Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab
Fabienne Courtois, Neeraj J Agrawal, Timothy M Lauer & Bernhardt L Trout
Pages: 99-112
Published online: 30 Dec 2015
AbstractforRational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab | Full Text | References | PDF (755.9 KB) | Supplemental
  • 5435 Views
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Report
Influence of molecular size on tissue distribution of antibody fragments
Zhe Li, Ben-Fillippo Krippendorff, Sharad Sharma, Antje C. Walz, Thierry Lavé & Dhaval K. Shah
Pages: 113-119
Published online: 09 Dec 2015
AbstractforInfluence of molecular size on tissue distribution of antibody fragments | Full Text | References | PDF (396.1 KB) | Supplemental
  • 5921 Views
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Report
Pharmacokinetic properties of IgG and various Fc fusion proteins in mice
Felix Unverdorben, Fabian Richter, Meike Hutt, Oliver Seifert, Pauline Malinge, Nicolas Fischer & Roland E. Kontermann
Pages: 120-128
Published online: 30 Dec 2015
AbstractforPharmacokinetic properties of IgG and various Fc fusion proteins in mice | Full Text | References | PDF (639.6 KB)
  • 7137 Views
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Report
Rapid isolation of dengue-neutralizing antibodies from single cell-sorted human antigen-specific memory B-cell cultures
Kara S. Cox, Aimin Tang, Zhifeng Chen, Melanie S. Horton, Hao Yan, Xin-Min Wang, Sheri A. Dubey, Daniel J. DiStefano, Andrew Ettenger, Rachel H. Fong, Benjamin J. Doranz, Danilo R. Casimiro & Kalpit A. Vora
Pages: 129-140
Published online: 19 Dec 2015
AbstractforRapid isolation of dengue-neutralizing antibodies from single cell-sorted human antigen-specific memory B-cell cultures | Full Text | References | PDF (834.7 KB) | Supplemental
  • 5557 Views
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Open Access
Report
Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
Michela Silacci, Wibke Lembke, Richard Woods, Isabella Attinger-Toller, Nadja Baenziger-Tobler, Sarah Batey, Roger Santimaria, Ulrike von der Bey, Susann Koenig-Friedrich, Wenjuan Zha, Bernd Schlereth, Mathias Locher, Julian Bertschinger & Dragan Grabulovski
Pages: 141-149
Published online: 13 Oct 2015
AbstractforDiscovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases | Full Text | References | PDF (490.9 KB) | Supplemental
  • 4757 Views
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Open Access
Report
Generation and preclinical characterization of an antibody specific for SEMA4D
Terrence L. Fisher, Christine A. Reilly, Laurie A. Winter, Tracy Pandina, Alan Jonason, Maria Scrivens, Leslie Balch, Holm Bussler, Sebold Torno, Jennifer Seils, Loretta Mueller, He Huang, Ekaterina Klimatcheva, Alan Howell, Renee Kirk, Elizabeth Evans, Mark Paris, John E. Leonard, Ernest S. Smith & Maurice Zauderer
Pages: 150-162
Published online: 11 Nov 2015
AbstractforGeneration and preclinical characterization of an antibody specific for SEMA4D | Full Text | References | PDF (879.9 KB)
  • 2975 Views
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Report
Molecular basis for the antagonistic activity of an anti-CXCR4 antibody
Li Peng, Melissa M. Damschroder, Kimberly E. Cook, Herren Wu & William F. Dall'Acqua
Pages: 163-175
Published online: 30 Dec 2015
AbstractforMolecular basis for the antagonistic activity of an anti-CXCR4 antibody | Full Text | References | PDF (1.4 MB)
  • 2354 Views
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Report
Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody
Roy Eylenstein, Daniel Weinfurtner, Stefan Härtle, Ralf Strohner, Jark Böttcher, Martin Augustin, Ralf Ostendorp & Stefan Steidl
Pages: 176-186
Published online: 15 Oct 2015
AbstractforMolecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody | Full Text | References | PDF (1,012.4 KB) | Supplemental
  • 2481 Views
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Report
Immunological evaluation of rheumatoid arthritis patients treated with itolizumab
Lazaro E. Aira, Patricia Hernández, Dinorah Prada, Araceli Chico, Jorge A. Gómez, Zuyén González, Karla Fuentes, Carmen Viada & Zaima Mazorra
Pages: 187-195
Published online: 11 Nov 2015
AbstractforImmunological evaluation of rheumatoid arthritis patients treated with itolizumab | Full Text | References | PDF (509.1 KB) | Supplemental
  • 1349 Views
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Erratum

Correction
Erratum
Page: 196
Published online: 30 Dec 2015
CitationforErratum | Full Text | PDF (30 KB)
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