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mAbs Volume 8, 2016 - Issue 2
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Identification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cells

Zhirui LianBioproduct Research and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN46285, USACorrespondence[email protected]
,
Qindong WuBioproduct Research and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN46285, USA
&
Tongtong WangBioproduct Research and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN46285, USA
Pages 358-370 | Received 16 Sep 2015, Accepted 01 Nov 2015, Published online: 20 Jan 2016

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Claire Harris, Weichen Xu, Luigi Grassi, Chunlei Wang, Abigail Markle, Colin Hardman, Richard Stevens, Guillermo Miro-Quesada, Diane Hatton & Jihong Wang. (2019) Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis. mAbs 11:8, pages 1452-1463.
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Douglas S. Rehder, Chris J. Wisniewski, Dengfeng Liu, Diya Ren, Dell Farnan & Matthew R. Schenauer. (2019) Expression vector-derived heterogeneity in a therapeutic IgG4 monoclonal antibody. mAbs 11:1, pages 145-152.
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Dan Boyd, Arpa Ebrahimi, Sarah Ronan, Brian Mickus, Matthew Schenauer, Jenny Wang, Darren Brown & Alexandre Ambrogelly. (2018) Isolation and characterization of a monoclonal antibody containing an extra heavy-light chain Fab arm. mAbs 10:3, pages 346-353.
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Articles from other publishers (4)

Jared A. Delmar, Claire Harris, Luigi Grassi, Nathaniel Macapagal, Jihong Wang, Diane Hatton & Weichen Xu. (2022) Monoclonal Antibody Sequence Variants Disguised as Fragments: Identification, Characterization, and Their Removal by Purification Process Optimization. Journal of Pharmaceutical Sciences 111:11, pages 3009-3016.
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Anushikha Thakur, Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V. Pai & Ramakrishnan Melarkode Subbaraman. (2021) Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study. Scientific Reports 11:1.
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Chong-Feng Xu, Yan Wang, Pete Bryngelson, Zoran Sosic & Li Zang. 2019. Advancements of Mass Spectrometry in Biomedical Research. Advancements of Mass Spectrometry in Biomedical Research 225 236 .
Yueming Qian, Zhiqiang Chen, Xin Huang, Xuning Wang, Xuankuo Xu, Stefan Kirov, Richard Ludwig, Nan‐Xin Qian, Kandasamy Ravi, Li Tao, Michael C. Borys & Zheng Jian Li. (2018) Early identification of unusually clustered mutations and root causes in therapeutic antibody development. Biotechnology and Bioengineering 115:9, pages 2377-2382.
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