mAbs, Volume 8, Issue 2 (2016)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

mAbs, Volume 8, Issue 2 (2016)

See all volumes and issues
Vol 16, 2024 Vol 15, 2023 Vol 14, 2022 Vol 13, 2021 Vol 12, 2020 Vol 11, 2019 Vol 10, 2018 Vol 9, 2017 Volume 8, 2016 Vol 7, 2015 Vol 6, 2014 Vol 5, 2013 Vol 4, 2012 Vol 3, 2011 Vol 2, 2010 Vol 1, 2009
Download citations Download PDFs Download issue

Perspective

Article Commentary
Antibodies to watch in 2016
Janice M. Reichert
Pages: 197-204
Published online: 03 Feb 2016
AbstractforAntibodies to watch in 2016 | Full Text | References | PDF (338.2 KB)
  • 18215 Views
  • 156 CrossRef citations
  • 0Altmetric
Free Access

Review

Review
Glycan analysis of therapeutic glycoproteins
Lei Zhang, Shen Luo & Baolin Zhang
Pages: 205-215
Published online: 08 Feb 2016
AbstractforGlycan analysis of therapeutic glycoproteins | Full Text | References | PDF (897.3 KB)
  • 14251 Views
  • 137 CrossRef citations
  • 0Altmetric
Open Access
Review
Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development
Dheeraj S. Tomar, Sandeep Kumar, Satish K. Singh, Sumit Goswami & Li Li
Pages: 216-228
Published online: 08 Feb 2016
AbstractforMolecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development | Full Text | References | PDF (718.2 KB) | Supplemental
  • 8195 Views
  • 126 CrossRef citations
  • 0Altmetric
Free Access
Review
Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
Jay Tibbitts, David Canter, Ryan Graff, Alison Smith & Leslie A. Khawli
Pages: 229-245
Published online: 08 Feb 2016
AbstractforKey factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development | Full Text | References | PDF (496.9 KB)
  • 13906 Views
  • 112 CrossRef citations
  • 0Altmetric
Open Access

Short Communication

Rapid Communication
Incomplete target neutralization by the anti-cancer antibody rilotumumab
Sameer A. Greenall, Timothy E. Adams & Terrance G. Johns
Pages: 246-252
Published online: 18 Feb 2016
AbstractforIncomplete target neutralization by the anti-cancer antibody rilotumumab | Full Text | References | PDF (937.7 KB) | Supplemental
  • 1157 Views
  • 15 CrossRef citations
  • 0Altmetric
Free Access

Report

Report
A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors
Carl I. Webster, Christine J. Bryson, Edward A. Cloake, Tim D. Jones, Mark J. Austin, Anette C. Karle, Sebastian Spindeldreher, David C. Lowe & Matthew P. Baker
Pages: 253-263
Published online: 08 Feb 2016
AbstractforA comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors | Full Text | References | PDF (955 KB) | Supplemental
  • 2725 Views
  • 7 CrossRef citations
  • 0Altmetric
Open Access
Report
Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms
Yasmina Noubia Abdiche, Rian Harriman, Xiaodi Deng, Yik Andy Yeung, Adam Miles, Winse Morishige, Leila Boustany, Lei Zhu, Shelley Mettler Izquierdo & William Harriman
Pages: 264-277
Published online: 08 Feb 2016
AbstractforAssessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms | Full Text | References | PDF (1.7 MB) | Supplemental
  • 4292 Views
  • 37 CrossRef citations
  • 0Altmetric
Open Access
Report
Understanding differences between synthetic and natural antibodies can help improve antibody engineering
Anat Burkovitz & Yanay Ofran
Pages: 278-287
Published online: 28 Jan 2016
AbstractforUnderstanding differences between synthetic and natural antibodies can help improve antibody engineering | Full Text | References | PDF (906.9 KB) | Supplemental
  • 4360 Views
  • 18 CrossRef citations
  • 0Altmetric
Free Access
Report
VH-VL orientation prediction for antibody humanization candidate selection: A case study
Alexander Bujotzek, Florian Lipsmeier, Seth F Harris, Jörg Benz, Andreas Kuglstatter & Guy Georges
Pages: 288-305
Published online: 18 Feb 2016
AbstractforVH-VL orientation prediction for antibody humanization candidate selection: A case study | Full Text | References | PDF (2.9 MB) | Supplemental
  • 3579 Views
  • 31 CrossRef citations
  • 0Altmetric
Free Access
Report
A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection
Robert E. Birdsall, Sean M. McCarthy, Marie Claire Janin-Bussat, Michel Perez, Jean-François Haeuw, Weibin Chen & Alain Beck
Pages: 306-317
Published online: 20 Jan 2016
AbstractforA sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection | Full Text | References | PDF (930.5 KB)
  • 4426 Views
  • 37 CrossRef citations
  • 0Altmetric
Open Access
Report
Full validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing
Anja Resemann, Wolfgang Jabs, Anja Wiechmann, Elsa Wagner, Olivier Colas, Waltraud Evers, Eckhard Belau, Lars Vorwerg, Catherine Evans, Alain Beck & Detlev Suckau
Pages: 318-330
Published online: 08 Feb 2016
AbstractforFull validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing | Full Text | References | PDF (1.7 MB) | Supplemental
  • 4476 Views
  • 51 CrossRef citations
  • 0Altmetric
Open Access
Report
Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
Markus Haberger, Michael Leiss, Anna-Katharina Heidenreich, Oxana Pester, Georg Hafenmair, Michaela Hook, Lea Bonnington, Harald Wegele, Markus Haindl, Dietmar Reusch & Patrick Bulau
Pages: 331-339
Published online: 28 Jan 2016
AbstractforRapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry | Full Text | References | PDF (1 MB) | Supplemental
  • 8339 Views
  • 106 CrossRef citations
  • 0Altmetric
Open Access
Report
Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion
Renpeng Liu, John Giddens, Colleen M. McClung, Paula E. Magnelli, Lai-Xi Wang & Ellen P. Guthrie
Pages: 340-346
Published online: 09 Dec 2015
AbstractforEvaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion | Full Text | References | PDF (736.6 KB) | Supplemental
  • 2859 Views
  • 15 CrossRef citations
  • 0Altmetric
Open Access
Report
CHO cell production and sequence improvement in the 13C6FR1 anti-Ebola antibody
Dean K. Pettit, Richard S. Rogers, Kelly Arthur, Yan Brodsky, Rutilio H. Clark, Chris Crowell, Jane Ennis, Alison Gillespie, Ron Gillespie, Brittney Livingston, Edith Nalbandian, Danielle Pace, Pauline Smidt, Michael Pauly, Ken Timmons, Michael Trentalange, Kevin J. Whaley, Larry Zeitlin & James N. Thomas
Pages: 347-357
Published online: 18 Feb 2016
AbstractforCHO cell production and sequence improvement in the 13C6FR1 anti-Ebola antibody | Full Text | References | PDF (1.1 MB)
  • 1861 Views
  • 15 CrossRef citations
  • 0Altmetric
Free Access
Report
Identification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cells
Zhirui Lian, Qindong Wu & Tongtong Wang
Pages: 358-370
Published online: 20 Jan 2016
AbstractforIdentification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cells | Full Text | References | PDF (1.1 MB)
  • 1270 Views
  • 7 CrossRef citations
  • 0Altmetric
Free Access
Report
Discovery and characterization of hydroxylysine in recombinant monoclonal antibodies
Qing Xie, Benjamin Moore & Richard L. Beardsley
Pages: 371-378
Published online: 28 Jan 2016
AbstractforDiscovery and characterization of hydroxylysine in recombinant monoclonal antibodies | Full Text | References | PDF (679 KB) | Supplemental
  • 2374 Views
  • 13 CrossRef citations
  • 0Altmetric
Free Access
Report
A method to confer Protein L binding ability to any antibody fragment
Zineb Lakhrif, Martine Pugnière, Corinne Henriquet, Anne di Tommaso, Isabelle Dimier-Poisson, Philippe Billiald, Matthieu O. Juste & Nicolas Aubrey
Pages: 379-388
Published online: 20 Jan 2016
AbstractforA method to confer Protein L binding ability to any antibody fragment | Full Text | References | PDF (1 MB)
  • 4000 Views
  • 21 CrossRef citations
  • 0Altmetric
Open Access
Report
Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms
Daniel Bedinger, Llewelyn Lao, Shireen Khan, Steve Lee, Toshihiko Takeuchi & Amer M. Mirza
Pages: 389-404
Published online: 20 Jan 2016
AbstractforDevelopment and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms | Full Text | References | PDF (1.7 MB) | Supplemental
  • 3369 Views
  • 29 CrossRef citations
  • 0Altmetric
Open Access

Reports

Report
Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy
Yun Yang, Qingcheng Guo, Xi Chen, Junjie Zhang, Huaizu Guo, Weizhu Qian, Sheng Hou, Jianxin Dai, Bohua Li, Yajun Guo & Hao Wang
Pages: 405-413
Published online: 18 Feb 2016
AbstractforPreclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy | Full Text | References | PDF (1,009.1 KB) | Supplemental
  • 2308 Views
  • 14 CrossRef citations
  • 0Altmetric
Free Access

Report

Report
Generation, characterization and preclinical studies of a human anti-L1CAM monoclonal antibody that cross-reacts with rodent L1CAM
Seulki Cho, Insoo Park, Haejung Kim, Mun Sik Jeong, Mooney Lim, Eung Suk Lee, Jin Hong Kim, Semi Kim & Hyo Jeong Hong
Pages: 414-425
Published online: 08 Feb 2016
AbstractforGeneration, characterization and preclinical studies of a human anti-L1CAM monoclonal antibody that cross-reacts with rodent L1CAM | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2550 Views
  • 8 CrossRef citations
  • 0Altmetric
Open Access

Explore articles