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mAbs Volume 8, 2016 - Issue 2
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Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy

Yun YangInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China
,
Qingcheng GuoInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China
,
Xi ChenInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China
,
Junjie ZhangState Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China
,
Huaizu GuoInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;Zhangjiang Biotechnology Co. Ltd, Shanghai, China
,
Weizhu QianInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;Zhangjiang Biotechnology Co. Ltd, Shanghai, China
,
Sheng HouInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China
,
Jianxin DaiInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China
,
Bohua LiInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China
,
Yajun GuoState Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;School of Pharmacy, Liaocheng University, Liaocheng, China;School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaCorrespondence[email protected]
&
Hao WangInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;School of Pharmacy, Liaocheng University, Liaocheng, China
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Pages 405-413 | Received 25 Sep 2015, Accepted 27 Nov 2015, Published online: 18 Feb 2016

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W. Michael Kavanaugh. (2020) Antibody prodrugs for cancer. Expert Opinion on Biological Therapy 20:2, pages 163-171.
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Articles from other publishers (13)

Longchao Liu & Jiahui Chen. (2023) Therapeutic antibodies for precise cancer immunotherapy: current and future perspectives. Medical Review 2:6, pages 555-569.
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Xiaoyue Wei & Shuqing Chen. 2023. Antibody-Drug Conjugates and Cellular Metabolic Dynamics. Antibody-Drug Conjugates and Cellular Metabolic Dynamics 69 82 .
Davinder Singh, Divya Dheer, Abhilash Samykutty & Ravi Shankar. (2021) Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development. Journal of Controlled Release 340, pages 1-34.
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Tao Yang, Yuki Mochida, Xueying Liu, Hang Zhou, Jinbing Xie, Yasutaka Anraku, Hiroaki Kinoh, Horacio Cabral & Kazunori Kataoka. (2021) Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nature Biomedical Engineering 5:11, pages 1274-1287.
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Yu Zhao, Yu-Qing Xie, Simon Van HerckSina NassiriMin Gao, Yugang Guo & Li Tang. (2021) Switchable immune modulator for tumor-specific activation of anticancer immunity. Science Advances 7:37.
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Wen-Wei Lin, Yun-Chi Lu, Chih-Hung Chuang & Tian-Lu Cheng. (2020) Ab locks for improving the selectivity and safety of antibody drugs. Journal of Biomedical Science 27:1.
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Heejae Kim, Andrew Gaynor & Wilfred Chen. (2019) Tunable modulation of antibody‐antigen interaction by protease cleavage of protein M. Biotechnology and Bioengineering 116:11, pages 2834-2842.
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Vivian H. Trang, Xinqun Zhang, Roma C. Yumul, Weiping Zeng, Ivan J. Stone, Serena W. Wo, Melissa M. Dominguez, Julia H. Cochran, Jessica K. Simmons, Maureen C. Ryan, Robert P. Lyon, Peter D. Senter & Matthew R. Levengood. (2019) A coiled-coil masking domain for selective activation of therapeutic antibodies. Nature Biotechnology 37:7, pages 761-765.
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Samantha R. Benjamin, Courtney P. Jackson, Siteng Fang, Dane P. Carlson, Zhongyuan Guo & L. Nathan Tumey. (2019) Thiolation of Q295: Site-Specific Conjugation of Hydrophobic Payloads without the Need for Genetic Engineering. Molecular Pharmaceutics 16:6, pages 2795-2807.
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Yun Yang, Ziyin Tian, Yanke Ding, Xiaojing Li, Ziheng Zhang, Liu Yang, Fangyu Zhao, Feng Ren & Rui Guo. (2018) EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway. Journal of Immunology Research 2018, pages 1-10.
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Oi Kwan Wong, Thomas-Toan Tran, Wei-Hsien Ho, Meritxell Galindo Casas, Melinda Au, Marjorie Bateman, Kevin C. Lindquist, Arvind Rajpal, David L. Shelton, Pavel Strop & Shu-Hui Liu. (2018) RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models. Oncotarget 9:71, pages 33446-33458.
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Junyeong Jin, Gunwoo Park, Jong Bae Park, Soohyun Kim, Hyori Kim & Junho Chung. (2018) An anti-EGFR × cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations. Experimental & Molecular Medicine 50:5, pages 1-14.
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Boning Liu, Huaizu Guo, Junjie Zhang, Jingya Xue, Yun Yang, Ting Qin, Jin Xu, Qingcheng Guo, Dapeng Zhang, Weizhu Qian, Bohua Li, Sheng Hou, Jianxin Dai, Yajun Guo & Hao Wang. (2016) In-Depth Characterization of a Pro-Antibody–Drug Conjugate by LC–MS. Molecular Pharmaceutics 13:8, pages 2702-2710.
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