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The application of mathematical modelling to the design of bispecific monoclonal antibodies

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Pages 585-592 | Received 10 Jul 2015, Accepted 07 Jan 2016, Published online: 04 Mar 2016

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Read on this site (3)

William J.J. Finlay & Alexey A. Lugovskoy. (2019) De novo discovery of antibody drugs – great promise demands scrutiny. mAbs 11:5, pages 809-811.
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Bram G. Sengers, Sean McGinty, Fatma Z. Nouri, Maryam Argungu, Emma Hawkins, Aymen Hadji, Andrew Weber, Adam Taylor & Armin Sepp. (2016) Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion. mAbs 8:5, pages 905-915.
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Jin Niu, Weirong Wang & Daniele Ouellet. Mechanism-based pharmacokinetic and pharmacodynamic modeling for bispecific antibodies: challenges and opportunities. Expert Review of Clinical Pharmacology 0:0, pages 1-14.
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Articles from other publishers (7)

Rajbharan Yadav, Siddharth Sukumaran, Tanja S. Zabka, Jinze Li, Amy Oldendorp, Gary Morrow, Arthur Reyes, Melissa Cheu, Jessica Li, Jeffrey J. Wallin, Siao Tsai, Laura Sun, Peiyin Wang, Diego Ellerman, Christoph Spiess, Andy Polson, Eric G. Stefanich, Amrita V. Kamath & Meric A. Ovacik. (2022) Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies. Pharmaceutics 14:5, pages 970.
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Yu Tang & Yanguang Cao. (2021) Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions. Pharmaceutics 13:3, pages 422.
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John P. Gibbs, Theresa Yuraszeck, Carla Biesdorf, Yang Xu & Sreeneeranj Kasichayanula. (2020) Informing Development of Bispecific Antibodies Using Physiologically Based Pharmacokinetic‐Pharmacodynamic Models: Current Capabilities and Future Opportunities. The Journal of Clinical Pharmacology 60:S1.
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Alison Betts & Piet H. van der Graaf. (2020) Mechanistic Quantitative Pharmacology Strategies for the Early Clinical Development of Bispecific Antibodies in Oncology. Clinical Pharmacology & Therapeutics 108:3, pages 528-541.
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Sonja Kunstmann, Olof Engström, Marko Wehle, Göran Widmalm, Mark Santer & Stefanie Barbirz. (2020) Increasing the Affinity of an O‐Antigen Polysaccharide Binding Site in Shigella flexneri Bacteriophage Sf6 Tailspike Protein . Chemistry – A European Journal 26:32, pages 7263-7273.
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Johannes Schropp, Antari Khot, Dhaval K. Shah & Gilbert Koch. (2019) Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy. CPT: Pharmacometrics & Systems Pharmacology 8:3, pages 177-187.
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A Trivedi, S Stienen, M Zhu, H Li, T Yuraszeck, J Gibbs, T Heath, R Loberg & S Kasichayanula. (2017) Clinical Pharmacology and Translational Aspects of Bispecific Antibodies. Clinical and Translational Science 10:3, pages 147-162.
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